In this paper, we investigate the existence and uniqueness of solutions for Riemann–Liouville fractional integro-differential equations equipped with fractional nonlocal multi-point and strip boundary conditions in the weighted space. The methods of our study include the well-known tools of the fixed point theory, which are commonly applied to establish the existence theory for the initial and boundary value problems after converting them into the fixed point problems. We also discuss the case when the nonlinearity depends on the Riemann–Liouville fractional integrals of the unknown function. Numerical examples illustrating the main results are presented.