Botulinumtoxintherapie beim idiopathischen Torticollis spasmodicus

Laskawi, R.; Drobik, Christian

doi:10.1159/000313032

Cited by 2 publications

(2 citation statements)

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“…Side effects were not reported by the patients. As opposed to our experiences with toxin treatment of muscular dyskinesias, 14‐17 the effect of BOTOX therapy in persons with Frey's syndrome was much extended. The subjective reports of 18 patients (with or without recurrence of gustatory sweating [one patient was lost to follow‐up]) showed that the full effect of the first injection lasted for a period ranging from 11 to 27 months (mean, 17.3 months).…”

Section: Resultsmentioning

confidence: 78%

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Up‐to‐date Report of Botulinum Toxin Type A Treatment in Patients With Gustatory Sweating (Frey's Syndrome)

1998

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Several therapeutic approaches exist to treat gustatory sweating (Frey's syndrome) following parotidectomy. Because of the lack of effective treatment, a new therapeutic modality using botulinum toxin injections was presented previously by our group. The duration of the demonstrated positive effect was essentially unknown so far. Based on our experiences using this technique since December 1993, the purpose of this clinical investigation was to make an up-to-date report and demonstrate the duration of effect of BOTOX injections in patients with severe gustatory sweating. Nineteen patients with severe gustatory sweating have been treated with BOTOX by intracutaneous injections into the affected skin areas. The maximal follow-up time was 33 months. The results were obtained by interviews and controls using Minor's starch iodine test. In all treated cases (n = 19 patients, 22 treated sides) gustatory sweating ceased completely within 2 days. Side effects were absent. In 12 patients gustatory sweating reappeared. The mean duration of effect was 17.3 months (subjective personal communication of 18 patients). Findings show that intracutaneous injection of BOTOX is a highly effective, safe, and minimally invasive treatment of Frey's syndrome with long-lasting therapeutic effect.

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Section: Resultsmentioning

confidence: 78%

“…Based on our experience with the application of the toxin to treat movement disorders of craniofacial muscles, 14‐17 we were surprised to notice the long periods during which BOTOX was sufficient in controlling Frey's syndrome. Similar observations were made by other authors 12 who dealt with single cases.…”

Section: Discussionmentioning

confidence: 99%

Up‐to‐date Report of Botulinum Toxin Type A Treatment in Patients With Gustatory Sweating (Frey's Syndrome)

1998

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Frey's Syndrome: Treatment with Botulinum Toxin

Drobik

Laskawi

1995

Acta Oto-Laryngologica

174

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The effectiveness of botulinum toxin injections for the management of Frey's syndrome was studied. Botulinum toxin A (approximately 0.5 Units/cm2) was injected intracutaneously into the affected skin area as determined by Minor's starch iodine test. Gustatory sweating in the treated skin area ceased completely within 1 week and has not reappeared (12 months follow up until now in the first treated case). There have been no side effects. It is concluded that local botulinum toxin injections are a highly effective and safe treatment for Frey's syndrome. Additional study is required to evaluate the duration of the therapeutic effect.

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Botulinumtoxintherapie beim idiopathischen Torticollis spasmodicus

Cited by 2 publications

References 10 publications

Up‐to‐date Report of Botulinum Toxin Type A Treatment in Patients With Gustatory Sweating (Frey's Syndrome)

Up‐to‐date Report of Botulinum Toxin Type A Treatment in Patients With Gustatory Sweating (Frey's Syndrome)

Frey's Syndrome: Treatment with Botulinum Toxin

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