Botulinum Toxin Type A for the Treatment of the Spastic Equinus Foot in Cerebral Palsy

Cardoso, Elyzabeth da Cruz; Rodrigues, Bernardo Minelli; Barroso, Marcelo Francini Girão; Menezes, Carla; Lucena, Rita; Nora, Daniel Bocchese; Melo, Aílton

doi:10.1016/j.pediatrneurol.2005.08.010

Cited by 47 publications

(33 citation statements)

References 14 publications

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“…Among patients with cerebral palsy 70% have spasticity, which results in asymmetric muscle function. 1 The altered innervation of individual muscles produces either spasticity or weakness, causing imbalances of muscle activity across joints. With growth, the imbalance between agonists and antagonists often progresses to joint and bony deformities and muscle contracture.…”

Section: Introductionmentioning

confidence: 99%

The management of spastic equinus in cerebral palsy

Čobeljić¹,

Bumbaširević²,

Lešić³

et al. 2009

Orthopaedics and Trauma

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Section: Introductionmentioning

confidence: 99%

The management of spastic equinus in cerebral palsy

Čobeljić¹,

Bumbaširević²,

Lešić³

et al. 2009

Orthopaedics and Trauma

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“…Botulinum toxin type A (BT-A) has been used in several neurological diseases such as dystonia, spasticity, hyperhydrosis and sialorrhea [1][2][3][4][5] . In cervical dystonia, pain is relieved more satisfactorily than torticollis, and tipically it is perceived before muscle relaxation is observed 6 .…”

mentioning

confidence: 99%

Botulinum toxin type A in refractory chronic migraine: an open-label trial

Menezes

Rodrigues

Magalhães

et al. 2007

Arq. Neuro-Psiquiatr.

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-Botulinum toxin type A (BT-A) has been described as an important strategy to various types of pain such as cervical dystonia, myofascial pain syndrome and headache. Although BT-A efficacy has not been proven in tension type headache, its use in migraine continues controversial. In this open trial, we evaluated the efficacy of BT-A in refractory migraine. BT-A was injected in patients diagnosed with migraine who had previously used three classes of prophylactic drugs by at least one year with no response. The most important improvement was observed within 30 days, but pain intensity and frequency of headache had been decreased until the end of three months of follow up. Side effects of BT-A were mild and self limited. We conclude that BT-A seems to be a safe and effective treatment to refractory migraine patients.Key WoRdS: botulinum toxin type A, migraine, pain, refractory pain.toxina botulínica tipo A no tratamento da enxaqueca refratária: um estudo aberto ReSUMo -Toxina botulínica tipo A (TB-A) tem sido descrita como importante estratégia para diversos tipos de dor como cefaléia e dores relacionadas a distonia cervical ou síndrome miofascial. embora a eficá-cia da TB-A não tenha sido demonstrada na cefaléia do tipo tensional, seu uso na enxaqueca continua controverso. Nesse estudo avaliamos a eficácia da TB-A na enxaqueca refratária. TB-A foi injetada em pacientes com enxaqueca que fizeram tratamento prévio com no mínimo três classes de medicamentos profiláti-cos, sem resultados satisfatórios. A melhora mais significativa dos pacientes foi observada após 30 dias de aplicação de TB-A, enquanto intensidade da dor e freqüência de cefaléia continuaram reduzidas até o final de três meses de seguimento. os efeitos colaterais observados após a aplicação de TB-A foram moderados e auto-limitados. os nossos dados mostram que TB-A parece ser um tratamento seguro e eficaz para pacientes com enxaqueca refratária.PAlAvRAS-ChAve: toxina botulínica do tipo A, enxaqueca, dor, dor refratária.

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“…Of 82 patients who were examined up to 65 months after surgery, 74 reported an increase in their walking distance even if moderate. But we also found a study which confirms the efficiency of botulinum toxin injection for equinus foot [16]. So a good multidisciplinary evaluation should be carried out to find the better management depending on the situation.…”

Section: Discussionmentioning

confidence: 60%