Botulinum Toxin Type A for the Treatment of Axillary Hailey–Hailey Disease

Lapiere, Jean Christophe; Hirsh, A.H.; Gordon, Kenneth B.; Cook, Brian N.; Montalvo, Augusto

doi:10.1046/j.1524-4725.2000.99278.x

Cited by 78 publications

(56 citation statements)

References 32 publications

(50 reference statements)

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“…[23][24][25][26][27][28][29][30][31][32][33] Botulinum toxin (axillary or inframammary) may help by reducing sweating, as may breast reduction. [34][35][36] Although ultraviolet light may exacerbate Hailey-Hailey disease, PUVA was apparently effective in some patients. Suberythemal UVB controlled both psoriasis and co-existing Hailey-Hailey disease in another patient.…”

Section: Treatmentmentioning

confidence: 99%

Hailey Hailey disease-a rare case report

et al. 2016

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Hailey-Hailey disease is an autosomal dominant acantholytic disorder relatively uncommon in India. It is characterized by painful, pruritic, foul smelling vesicles and bullous lesions with erosions in intertriginous areas such as the neck, axillae, inframammary areas and groin. The defect in ATPC2 gene leads to calcium channel dysfunction which results in defect in epidermis. Fungal infection, intertrigo, psoriasis, extramammary Paget's disease, acanthosis nigricans, pemphigus vegetans and Darier's disease are some of the dermatosis from which it needs to be differentiated. Histopathology has a key role in diagnosis of Hailey-Hailey disease with characteristic ‘dilapidated brick wall' appearance. Hailey-Hailey disease can be easily misdiagnosed by general physicians due to lack of knowledge of this uncommon disease as it resembles dermatosis involving intertriginous areas. Due to its relapsing and remitting course there is a need to have effective treatment options. We report a case of 45 year old middle aged female who presented with on and off itchy papules & vesicles over right inframammmary region around the umbilicus & medial aspect of right thigh. Skin biopsy revealed a diagnosis of Hailey-Hailey disease. This case is being reported due to its rare occurrence.

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Section: Treatmentmentioning

confidence: 99%

Hailey Hailey disease-a rare case report

et al. 2016

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“…It would also lead to less irritation stimulated by the natural rub in the areas of folds. 12 We presented here two cases in which the BTA proved to be a good adjuvant in patients with recurrent disease and limited response to classical treatment. Its use made it possible to save the use of systemic antibiotics and topic corticosteroids, which was particularly important for a patient that already presented advanced signs of cutaneous atrophy in the fold areas.…”

Section: Discussionmentioning

confidence: 94%

“…For this reason, it is recommended an intensive treatment including those patients with few lesions. 16 Lapiere et al reported the case of a patient who had had an applications of 50U of BTA in each axilla, having had complete remission of the lesions in these areas, 12 similarly to patient 1 who, during the summer, developed lesions on the groin region, site not treated with BTA, while it remained asymptomatic on the axillae.…”

Section: Discussionmentioning

confidence: 97%

“…It is generally used in association with other therapeutic modalities in patients with severe disease or resistant to conventional treatment. 12,13 It was reported, recently, an improvement in the disease with the isolated application of BTA comparable with its associated use of dermoabrasion and erbium:YAG laser. 14 In the present report it is shown the use of BTA as an adjuvant therapy in two sisters HHD carriers with limited response to classical treatment…”

Section: Introductionmentioning

confidence: 99%

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Tratamento da doença de Hailey-Hailey com toxina botulínica tipo A

Bessa

Grazziotin

Manzoni

et al. 2010

An. Bras. Dermatol.

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Two sisters with recurrent lesions, one on axillae and other on the groin, and with limited response to classical treatments were treated with injections botulinum toxin type A. We observed marked improvement in the patient treated in the groin and complete remission in the patient treated in the axillae. It was possible to spare the use of systemic antibiotics and topical corticosteroids. The high cost is a restrictive factor to routine use and large studies are necessary to access efficacy and cost benefit profile. Keywords: Botulinum toxin type A; Combined modality therapy; Pemphigus, benign familial Resumo: Duas irmãs com doença de Hailey-Hailey, com lesões recorrentes -uma em axilas e outra em região inguinal -, e resposta limitada aos tratamentos clássicos. Elas foram tratadas com aplicação de toxina botulínica tipo A. Observamos que houve importante melhora na paciente tratada na região inguinal e remissão completa na paciente em cujas axilas sofreram tratamento. Além disso, foi possível poupar uso de antibióticos sistêmicos e corticoides tópicos. O alto custo é um fator restritivo para uso rotineiro e estudos maiores são necessários para definir eficácia e relação custo-benefício dessa intervenção.

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“…Patients with axillary Hailey-Hailey disease are treated with botulinum toxin type A showed good response. [16] Other topical modalities are topical antibiotics, topical steroids, tacalcitol another vitamin D3 derivative and cyclosporine. Systemic treatment includes antibiotics, steroids, cyclosporine, dapsone, methotrexate and thalidomide.…”

Section: Figure 3bmentioning

confidence: 99%