Botulinum toxin type a combined with transcranial direct current stimulation reverses the chronic pain induced by osteoarthritis in rats

Li, Xinhe; Ye, Yinshuang; Wang, Lin; Zhou, Wenwen; Chu, Xiao; Li, Tieshan

doi:10.1016/j.toxicon.2022.04.005

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Transcranial direct current stimulation can induce neuroplasticity in a manner dependent on N-methyl-D-aspartate receptors (NMDARs) ( Liebetanz et al, 2002 ; Nitsche et al, 2003 ), which can regulate signaling pathways by allowing positively charged ions, such as calcium, to enter the cell and strengthen the synapse. Research also discovered that tDCS increased the amount of NMDA receptors and subsequently enhanced pain-related responses in animals ( Li et al, 2022a , b ). This suggests tDCS enhances NMDAR-mediated synaptic plasticity by increasing neuronal membrane NMDAR density, heightening synaptic responsiveness crucial to modulating pain.…”

Section: Mechanisms Of Tdcs For Fibromyalgia Syndromementioning

confidence: 99%

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

Wang,

Du,

Wang

et al. 2024

Front. Mol. Neurosci.

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Fibromyalgia syndrome (FMS) is a recurrent pain condition that can be challenging to treat. Transcranial direct current stimulation (tDCS) has become a promising non-invasive therapeutic option in alleviating FMS pain, but the mechanisms underlying its effectiveness are not yet fully understood. In this article, we discuss the most current research investigating the analgesic effects of tDCS on FMS and discuss the potential mechanisms. TDCS may exert its analgesic effects by influencing neuronal activity in the brain, altering cortical excitability, changing regional cerebral blood flow, modulating neurotransmission and neuroinflammation, and inducing neuroplasticity. Overall, evidence points to tDCS as a potentially safe and efficient pain relief choice for FMS by multiple underlying mechanisms. This article provides a thorough overview of our ongoing knowledge regarding the mechanisms underlying tDCS and emphasizes the possibility of further studies to improve the clinical utility of tDCS as a pain management tool.

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Section: Mechanisms Of Tdcs For Fibromyalgia Syndromementioning

confidence: 99%

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

Wang,

Du,

Wang

et al. 2024

Front. Mol. Neurosci.

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show abstract

“…fMRI studies show altered functional connectivity between cortical regions, thalamus, and PAG in OA [174]. Furthermore, transcranial direct current stimulation of the PAG in the rat model of OA has shown some pain-alleviating capabilities [175,176]. Another study that was focused on electroacupuncture suggests that it might exert its anti-noxious effects by potentiating the endocannabinoid-mediated system at the level of PAG [177].…”

Section: Central Sensitization the Brainstem Subcortex And Cerebral C...mentioning

confidence: 99%

From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review

Naumovs

Groma

Mednieks

2022

IJMS

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Nowadays, osteoarthritis (OA), a common, multifactorial musculoskeletal disease, is considered to have a low-grade inflammatory pathogenetic component. Lately, neuropsychiatric sequelae of the disease have gained recognition. However, a link between the peripheral inflammatory process of OA and the development of neuropsychiatric pathology is not completely understood. In this review, we provide a narrative that explores the development of neuropsychiatric disease in the presence of chronic peripheral low-grade inflammation with a focus on its signaling to the brain. We describe the development of a pro-inflammatory environment in the OA-affected joint. We discuss inflammation-signaling pathways that link the affected joint to the central nervous system, mainly using primary sensory afferents and blood circulation via circumventricular organs and cerebral endothelium. The review describes molecular and cellular changes in the brain, recognized in the presence of chronic peripheral inflammation. In addition, changes in the volume of gray matter and alterations of connectivity important for the assessment of the efficacy of treatment in OA are discussed in the given review. Finally, the narrative considers the importance of the use of neuropsychiatric diagnostic tools for a disease with an inflammatory component in the clinical setting.

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Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis

Zeng,

Liu,

Wang

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Botulinum toxin type a combined with transcranial direct current stimulation reverses the chronic pain induced by osteoarthritis in rats

Cited by 3 publications

References 38 publications

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review

Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis

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