Botulinum toxin therapy: a tempting tool in the management of salivary secretory disorders

Recurrent inflammation of accessory parotid tissue associated with unilateral parotid gland aplasia: diagnostic and therapeutic implications

“…First of all, the injection of botulinum toxin into the pathological accessory salivary tissue in order to silence the functioning of the residual salivary tissue, as is currently used by us for all salivary secretory disorders. Botulinum neurotoxin inhibits presynaptic acetylcholine release at the neuromuscular junctions of the salivary glands; this depresses parasympathetic-dependent secretory function, but avoids the xerostomia often encountered in patients with aplasia of the major salivary glands because basal Xow is maintained by the adrenergic pathway [19].…”

Botulinum toxin therapy: functional silencing of salivary disorders

“…Capaccio et al 24 reported the treatment by BTX of 3 patients with salivary fistula and 5 with sialocele: complete clinical recovery was observed in all but one patients. Furthermore, the authors focused on the need for a combination of traditional percutaneous aspiration of extravasated fluid and BTX injection to avoid invasive sialadenectomy 24 , as also proposed by other authors 16 . Laskawi and colleagues 25 reviewed their experience with BTX treatment in 12 post-parotidectomy salivary fistulae; they reported 90% of successful fistula closures if early treatment (within 6 weeks after development of the fistula) was performed.…”

“…BTX treatment has proven successful for the treatment of salivary fistula and sialocele, either post-traumatic or post-operative 6 - 11 16 17 19 23 - 25 . Capaccio et al 24 reported the treatment by BTX of 3 patients with salivary fistula and 5 with sialocele: complete clinical recovery was observed in all but one patients. Furthermore, the authors focused on the need for a combination of traditional percutaneous aspiration of extravasated fluid and BTX injection to avoid invasive sialadenectomy 24 , as also proposed by other authors 16 .…”

Fat injections for the management of post-parotidectomy Frey syndrome: A technical note

“…Local therapies include anticholinergic ointments (scopolamine, glycopyrrolate) (de Bree et al, 2007), or multiple intracutaneous botulinum toxin A injections (Beerens and Snow, 2002;Capaccio et al, 2008); more invasive surgical procedures include tympanic neurectomy (Hays et al, 1982) or the interposition of a dermal graft and temporoparietal fascia (MacKinnon and Lovie, 1999) between the skin and residual parotid tissue with the risk of possible facial nerve injury (de Bree et al, 2007).…”