Botulinum toxin is effective in the short term treatment forachalasia, preliminary results of arandomized study

Fiorini, A; Corti, RE; Valero, JL; Bai, JC; Boerr, Luis A.

doi:10.1016/s0016-5107(05)80063-x

Cited by 2 publications

(1 citation statement)

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“…The limitations of classic procedures prompted the use of injections of BoNT into the LES, based on the rationale that BoNT injections would inhibit an unbalanced cholinergic influence on the sphincter and improve esophageal emptying 56–81. The LES is easily injected during an upper endoscopy using a 5‐mm sclerotherapy needle.…”

Section: Applications In the Upper Gitmentioning

confidence: 99%

Treatment with botulinum neurotoxin of gastrointestinal smooth muscles and sphincters spasms

et al. 2004

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Local injections of botulinum neurotoxin are now considered an efficacious treatment for neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum neurotoxin provides benefit in diseases of the gastrointestinal tract. Botulinum neurotoxin inhibits contraction of gastrointestinal smooth muscles and sphincters; it has also been shown that the neurotoxin blocks cholinergic nerve endings in the autonomic nervous system, but it does not block nonadrenergic responses mediated by nitric oxide. This aspect has further promoted the interest to use botulinum neurotoxin as a treatment for overactive smooth muscles, such as the anal sphincters to treat anal fissure and outlet-type constipation, or the lower esophageal sphincter to treat esophageal achalasia. Knowledge of the anatomical and functional organization of innervation of the gastrointestinal tract is a prerequisite to understanding many features of botulinum neurotoxin action on the gut and the effects of injections placed into specific sphincters. This review presents current data on the use of botulinum neurotoxin to treat diseases of the gastrointestinal tract and summarizes recent knowledge on the pathogenesis of disorders of the gut due to a dysfunction of the enteric nervous system.

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Section: Applications In the Upper Gitmentioning

confidence: 99%