“…Burlina et al, 2004), HSS/PKAN(Lin et al, 2018;Neves et al, 2008), MLD(Borges et al, 2020;Singh et al, 2009), Pelizaeus-Merzbacher disease (PMD)(Brender et al, 2015), SLS(Anil G, 2019;Cho et al, 2018;Hidalgo et al, 2017), Alexander disease(Machol et al, 2018), Aicardi-Goutières syndrome (AGS)(Videira et al, 2020), Cockayne syndrome(Hsu et al, 2021)and in combination with epidural analgesia in one child with MSUD(Kaki & Arab, 2012…”