Shoulder pain is a common musculoskeletal complaint that can result from a variety of pathologic processes, including arthritis, bursitis and rotator cuff disease. Physicians often initiate treatment of shoulder pain with oral medications and progress to injectable medications for patients with more severe pain. Several promising new therapies for shoulder pain have emerged in recent years. These treatment modalities, which include cytokines, growth factors, platelet rich plasma, and stem cells, could provide physicians with powerful medications to treat patients with severe shoulder pain. This article provides a review of the biologic treatments available to physicians treating patients with shoulder pain and highlights some of the research and newest developments in the use of cytokines, growth factors, platelet rich plasma and stem cells for shoulder pathology.