Botulinum toxin for chronic anal fissure

Gui, Daniele; Anastasio, Gerardo; Maria, Giorgio; Cassetta, Emanuele; Bentivoglio, Anna Rita; Albanese, Alberto

doi:10.1016/s0140-6736(94)90633-5

Cited by 184 publications

(80 citation statements)

References 8 publications

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“…Botulinum toxin causes temporary muscle paralysis by preventing acetylcholine release from presynaptic nerve terminals, thereby decreasing the pressure in the internal sphincter [41,45] . The healing rate of anal fissures ranges from 60%-70% after a single injection of 15 or 20 U of the toxin [45,46] . One prospective randomized study showed that botulinum toxin had a better healing rate compared to 0.2% GTN ointment [47] .…”

Section: Treatmentmentioning

confidence: 99%

What every gastroenterologist needs to know about common anorectal disorders

Schubert¹,

Sridhar²,

Schade³

et al. 2009

WJG

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Anorectal complaints are very common and are caused by a variety of mostly benign anorectal disorders. Many anorectal conditions may be successfully treated by primary care physicians in the outpatient setting, but patients tend not to seek medical attention due to embarrassment or fear of cancer. As a result, patients frequently present with advanced disease after experiencing significant decreases in quality of life. A number of patients with anorectal complaints are referred to gastroenterologists. However, gastroenterologists' knowledge and experience in approaching these conditions may not be sufficient. This article can serve as a guide to gastroenterologists to recognize, evaluate, and manage medically or nonsurgically common benign anorectal disorders, and to identify when surgical referrals are most prudent. A review of the current literature is performed to evaluate comprehensive clinical pearls and management guidelines for each topic. Topics reviewed include hemorrhoids, anal fissures, anorectal fistulas and abscesses, and pruritus ani.

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Section: Treatmentmentioning

confidence: 99%

What every gastroenterologist needs to know about common anorectal disorders

Schubert¹,

Sridhar²,

Schade³

et al. 2009

WJG

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show abstract

“…Botulinum toxin injection into skeletal muscle has been used for many years in the treatment of strabismus and spasticity syndromes. 7 More recently, botulinum toxin has been used successfully to chemically relax smooth muscle in patients with esophageal achalasia 8 and chronic anal fissure, 9 as an alternative to the traditional forcible dilatation, or surgical incision of the sphincter.…”

mentioning

confidence: 99%

A prospective study of botulinum toxin for internal anal sphincter hypertonicity in children with Hirschsprung's disease

Minkes

Langer

2000

Journal of Pediatric Surgery

107

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Background:Internal anal sphincter hypertonicity with nonrelaxation can cause persistent constipation and obstructive symptoms in children after surgery for Hirschsprung's disease. Intractable symptoms traditionally have been treated with anal myectomy, which may be ineffective or complicated by long-term incontinence. The authors evaluated prospectively the use of intrasphincteric botulinum toxin for these patients.

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“…Anal fissure is a common and distressing problem. This original study is comprised of 120 cases, while Jensen et al [12] conducted a similar study recruiting 58 subjects, Gui et al [13] upon only 10 patients. However larger scale studies were also conducted on 1355 patients by Khubchandani et al in 1989 [14] Anal fissures occur roughly equally in both sexes.…”

Section: Volume 1 | Issue 1 Journal Of Antibiotics Researchmentioning

confidence: 99%

Chronic Anal Fissure - A Multi Centric Study

Ah¹,

Ah²,

Ar³

et al. 2017

JOURNAL OF ANTIBIOTICS RESEARCH

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Botulinum toxin for chronic anal fissure

Cited by 184 publications

References 8 publications

What every gastroenterologist needs to know about common anorectal disorders

What every gastroenterologist needs to know about common anorectal disorders

A prospective study of botulinum toxin for internal anal sphincter hypertonicity in children with Hirschsprung's disease

Chronic Anal Fissure - A Multi Centric Study

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