Botulinum toxin D ADP-ribosylates A 22–24 KDa membrane protein in platelets and HL-60 cells that is distinct from p21N-RAS

Banga, Harjit S.; Gupta, Sunil K.; Feinstein, Maurice B.

doi:10.1016/s0006-291x(88)81078-7

Cited by 18 publications

(2 citation statements)

References 15 publications

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“…Exoenzyme C3. Some investigators have reported that type C and D neurotoxins possess ADP-ribosylating activity, which would be the first enzymatic function to be established for any of the clostridial neurotoxins (15,186,234,235). This activity was convincingly shown to be due to botulinum ADP-ribosyltransferase C3 (4), an enzyme that was no doubt a contaminant of the C1 and D toxin preparations (266).…”

Section: Botulinal Neurotoxinsmentioning

confidence: 99%

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Toxigenic clostridia

1990

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Toxigenic clostridia belonging to 13 recognized species are discussed in this review. Each species or group of organisms is, in general, introduced by presenting the historical aspects of its discovery by early investigators of human and animal diseases. The diseases caused by each species or group are described and usually discussed in relation to the toxins involved in the pathology. Morphological and physiological characteristics of the organisms are described. Finally, the toxins produced by each organism are listed, with a presentation of their biological activities and physical and biochemical characteristics. The complete amino acid sequences for some are known, and some of the genes have been cloned. The term toxin is used loosely to include the various antigenic protein products of these organisms with biological and serological activities which have served as distinguishing characteristics for differentiation and classification. Some of these factors are not truly toxic and have no known role in pathogenicity. Some of the interesting factors common to more than one species or group are the following: neurotoxins, lethal toxins, lecithinases, oxygen-labile hemolysins, binary toxins, and ADP-ribosyltransferases. Problems in bacterial nomenclature and designation of biologically active factors are noted.

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Section: Botulinal Neurotoxinsmentioning

confidence: 99%

“…Several research groups reported ADP-ribosylating activity for C. botulinum type C and D neurotoxins (15,186,234,235). Subsequent evidence showed that the ADP-ribosylating activity in the neurotoxin preparations was due to another factor, C3, which was present as a contaminant (266).…”

Section: Binary Toxins and Adp-ribosylating Factorsmentioning

confidence: 99%