Botulinum Toxin Clinic-Based Epidemiologic Survey of Adults with Primary Dystonia in East China

Wang, Li; Hu, Xingyue; Liu, Chunfeng; Wu, Yiwen; Wang, Zhiqiang; Chen, Jun

doi:10.14802/jmd.12003

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…This wide range in prevalence estimates can be explained by the ways of selecting patients, such as age or genetic background of different populations, the specific clinical phenotypes and the methods of case [12,[14][15][16][17]20]. In Oriental populations very limited reports were found [5,11,13,18]. In 2012, a survey study was conducted in East China, which covered 523 primary dystonia patients, who visited clinics from six provinces within 6 months.…”

Section: Discussionmentioning

confidence: 99%

“…A previous survey [18] in East China showed that before initiation of botulinum toxin treatment, 382 patients (65.52 %) took oral medications, 67 patients (11.49 %) received acupuncture therapy and 30 patients (5.14 %) received physical therapy. Only 91 patients (15.61 %) received botulinum toxin treatment as the primary treatment modality.…”

Section: Discussionmentioning

confidence: 99%

“…And amongst the focal dystonias, cervical dystonia was the most occured throughout the world [12][13][14][15][16][17]. A botulinum toxin clinicbased epidemiological survey in China [18], which was conducted with 523 dystonia patients from six movement disorder clinics, revealed that the most common focal dystonia in China was blepharospasm (59 %), which is different from the reports in western countries; but was similar to that reported in Japan [5][6][7]. However, this survey study in China covered patients who visited the clinics within only 5 months.…”

Section: Introductionmentioning

confidence: 99%

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Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study

Wang

Chen

et al. 2015

Neurol Sci

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Dystonia is characterized by sustained muscle contractions, causing repetitive movements and abnormal postures. The epidemiological study of dystonia of Chinese population was limited reported. In this study, we investigated the epidemiology of primary dystonia, and its clinical characteristics in an adult population in China. We identified all dystonia patients from the movement disorders database and botulinum toxin clinic between 2009 and 2013. The medical records were reviewed to verify the diagnosis of dystonia, and demographic and clinical data were collected. A total of 1481 patients with primary dystonia were studied. The most common focal dystonia were blepharospasm (56.4 %), cervical dystonia (36.7 %), limb dystonia (3.4 %), oromandibular dystonia (2.9 %) and laryngeal dystonia (0.6 %). Males with primary dystonia were found to have an earlier age of onset. A female predominance was noted for most of the primary dystonia, with a men to women ratio (M:F) of 1:2.01. The minimum estimate of prevalence of primary dystonia was 27.0 (95 % confidence interval: 25.6-28.3) per million persons in this study. Despite the difference in genetic background and geographic area, the epidemiological features of dystonia in China from our study share most features around the world, such as women dystonia dominance, early-onset age of dystonia with women, etc. But East Asia countries (China and Japan) may share more common features of dystonia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study

Wang

Chen

et al. 2015

Neurol Sci

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“…port that BSP occurring with an incidence of 59% among patients with idiopathic dystonia was the most common focal form in east China. 10 This finding should give a reference value. The probability of BSP spreading to adjacent muscles is > 50%, especially within the first 5 years of onset, and can be mostly presented as Meige syndrome.…”

mentioning

confidence: 91%

Long-term follow-up of pallidal deep brain stimulation for craniocervical dystonia: is the globus pallidus internus the best target?

Zhao,

Ren,

et al. 2024

Neurosurgical Focus

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OBJECTIVE Craniocervical dystonia (CCD) is a common type of segmental dystonia, which is a disabling disease that has been frequently misdiagnosed. Blepharospasm or cervical dystonia is the most usual symptom initially. Although deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been widely used for treating CCD, its clinical outcome has been primarily evaluated in small-scale studies. This research examines the sustained clinical effectiveness of DBS of the GPi in individuals diagnosed with CCD. METHODS The authors report 24 patients (14 women, 10 men) with refractory CCD who underwent DBS of the GPi between 2016 and 2023. The severity and disability of the dystonia were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). The BFMDRS scores were collected preoperatively, 6 months postoperatively, and at the most recent follow-up visit. RESULTS The mean age at onset was 52.0 ± 11.0 years (range 33–71 years) and the mean disease duration was 63.3 ± 73.3 months (range 7–360 months) (values for continuous variables are expressed as the mean ± SD). The mean follow-up period was 37.5 ± 23.5 months (range 6–84 months). The mean total BFMDRS motor scores at the 3 different time points were 13.3 ± 9.4 preoperatively, 5.0 ± 4.7 (55.3% improvement, p < 0.001) at 6 months, and 4.5 ± 3.6 (56.6% improvement, p < 0.001) at last follow-up. The outcomes were deemed poor in 6 individuals. CONCLUSIONS Inferences drawn from the findings suggest that DBS of the GPi has long-lasting effectiveness and certain limitations in managing refractory CCD. The expected stability of the clinical outcome is not achieved. Patients with specific types of dystonia might consider targets other than GPi for a more precise therapy.

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“…Dystonia is a non-frequently occurring disorder and mortality and morbidity rate due to this disorder is too low and it can be considered as non-fatal. The prevalence rate of dystonia has been found 30 to 7320 per million of cases [4]. Another study revealed that an outbreak of primary dystonia was 16.43 per 100,000 patients where the confidence interval was 95% [5].…”

Section: Introductionmentioning

confidence: 98%

Dystonia: A Leading Neurological Movement Disorder

Kabir¹,

Yasmin²,

Khanam³

et al. 2018

J. Intellect. Disabl. Diagn. Treat.

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Dystonia is the third leading movement disorder arising mainly from the damage of basal ganglia or other parts of the brain that control movements. The objective of this review is to represent the detailed profile of dystonia. A computerized literature review was conducted in authentic scientific databases including PubMed, Google Scholar, Scopus, Science Direct and National Institutes of Health (NIH) etc. Terms searched included dystonia, risk factors, etiologies, clinical features, classification, pathology, guidelines, treatment strategies, primary and secondary dystonia. Initially, 97 articles and 9 books were extracted but finally, 64 articles and 7 books were used. After analysis, we found that causes of dystonia could be acquired or inherited and dystonia can be classified based on age at onset, etiology, and distribution of the affected body parts. The risk factors of this heterogeneous disorder could be trauma, thyroid disorder, hypertension, life habits, occupation, use of drugs and genetics. A significant number of articles were found which signify the ability of brainstem and cerebellar pathology to trigger the symptoms of dystonia. Since antipsychotic drugs are the most commonly prescribed among the people with intellectual disability (ID), therefore they possess a greater risk to experience antipsychotic drugs-induced movement side effects including acute dystonia, parkinsonism, tardive dyskinesia, and akathisia. Depending on various manifestations and causes, there are several treatment options including oral medications, intramuscular injection of botulinum toxin, neurosurgical procedures and occupational therapy.

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Botulinum Toxin Clinic-Based Epidemiologic Survey of Adults with Primary Dystonia in East China

Cited by 4 publications

References 26 publications

Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study

Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study

Long-term follow-up of pallidal deep brain stimulation for craniocervical dystonia: is the globus pallidus internus the best target?

Dystonia: A Leading Neurological Movement Disorder

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