2020
DOI: 10.3390/md18080410
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Abstract: Several experimental studies have recently demonstrated that temporary autonomic block using botulinum toxin (BoNT/A1) might be a novel option for the treatment of atrial fibrillation. However, the assessment of antiarrhythmic properties of BoNT has so far been limited, relying exclusively on vagal stimulation and rapid atrial pacing models. The present study examined the antiarrhythmic effect of specially formulated BoNT/A1-chitosan nanoparticles (BTN) in calcium chloride-, barium chloride- and electrically i… Show more

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Cited by 6 publications
(5 citation statements)
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References 43 publications
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“…Currently, the world literature is actively highlighting the prospect of using a natural polymer of chitosan [ 49 , 50 , 51 , 52 ]. It is noteworthy that the entire 62nd issue of Advanced Drug Delivery Reviews (2010) was devoted to this material.…”
Section: Discussionmentioning
confidence: 99%
“…Currently, the world literature is actively highlighting the prospect of using a natural polymer of chitosan [ 49 , 50 , 51 , 52 ]. It is noteworthy that the entire 62nd issue of Advanced Drug Delivery Reviews (2010) was devoted to this material.…”
Section: Discussionmentioning
confidence: 99%
“…Botulinum toxin (BoTN) is a neurotoxin that acts on neural synapses, blocking the release of acetylcholine-containing synaptic vesicles from the presynaptic membrane, reducing vagus-induced shortening of the atrial effective refractory period and preventing autonomic remodeling ( 84 , 85 ). The use of BoNT to block GPs is temporary, and there is no permanent structural damage; such an effect is favorable.…”
Section: Practical Application Of Af Treatment Methods Based On Nano ...mentioning
confidence: 99%
“…Clostridium botulinum is a Gram-positive anaerobic spore-forming bacterium found in marine environments [ 126 ]. The botulinum toxin (BoNT/A1)–chitosan nanoparticles (BTN) formulation inhibits arrhythmia caused by sodium, calcium, and potassium channel activation [ 89 ].…”
Section: Role Of Marine Drugs In Cvds Managementmentioning
confidence: 99%