Botulinum Toxin-Chitosan Nanoparticles Prevent Arrhythmia in Experimental Rat Models

Sergeevichev, David; Фоменко, В. В.; Стрельников, А. Г.; Dokuchaeva, Anna A.; Vasilieva, Maria; Chepeleva, Elena V.; Rusakova, Yanina; Artemenko, Sergey; Romanov, Alexander; Salakhutdinov, N. F.; Chernyavskiy, Alexander

doi:10.3390/md18080410

Cited by 6 publications

(5 citation statements)

References 43 publications

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“…The formulation of dosage forms plays a crucial role in the delivery, bioavailability, and stability of marine-derived compounds [17][18][19][20][21]. The topical application of drugs has several advantages compared to other routes of administration.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its anti-inflammatory potential after topical application in vivo. Fucoidan from Fucus vesiculosus L. was used. The cream base consisting of olive oil and Kolliphor RH40 was optimized followed by in vitro agar diffusion and drug release studies. The fucoidan-based cream with 13% Kolliphor P 407, 1% Transcutol P, and 5% PEG400 showed good spreadability, washability, and colloidal stability, and it did not irritate the skin. The kinetics of fucoidan release from the optimized cream exhibited the best fit to the Korsmeyer–Peppas and Higuchi models with R2 > 0.99. Fucoidan release was controlled by drug diffusion and anomalous transport provided by the optimized cream base. The formulation was stable and provided high fucoidan release after storage for 1 year. Topical application of the fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia in rats. The efficacy of the fucoidan-based cream at a high dose was comparable with the efficacy of diclofenac gel. The fucoidan-based cream could be considered a promising anti-inflammatory formulation.

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Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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“…Currently, the world literature is actively highlighting the prospect of using a natural polymer of chitosan [ 49 , 50 , 51 , 52 ]. It is noteworthy that the entire 62nd issue of Advanced Drug Delivery Reviews (2010) was devoted to this material.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications

et al. 2021

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Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005).

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“…Botulinum toxin (BoTN) is a neurotoxin that acts on neural synapses, blocking the release of acetylcholine-containing synaptic vesicles from the presynaptic membrane, reducing vagus-induced shortening of the atrial effective refractory period and preventing autonomic remodeling ( 84 , 85 ). The use of BoNT to block GPs is temporary, and there is no permanent structural damage; such an effect is favorable.…”

Section: Practical Application Of Af Treatment Methods Based On Nano ...mentioning

confidence: 99%

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

Wang

Tong

et al. 2022

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) is one of the most common sustained tachyarrhythmias worldwide, and its prevalence is positively correlated with aging. AF not only significantly reduces the quality of life of patients but also causes a series of complications, such as thromboembolism, stroke, and heart failure, increases the average number of hospitalizations of patients, and places a huge economic burden on patients and society. Traditional drug therapy and ablation have unsatisfactory success rates, high recurrence rates, and the risk of serious complications. Surgical treatment is highly traumatic. The nano drug delivery system has unique physical and chemical properties, and in the application of AF treatment, whether it is used to assist in enhancing the ablation effect or for targeted therapy, it provides a safer, more effective and more economical treatment strategy.

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Botulinum Toxin-Chitosan Nanoparticles Prevent Arrhythmia in Experimental Rat Models

Cited by 6 publications

References 43 publications

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

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