Botulinum toxin a may be efficacious as treatment for jaw tremor in Parkinson's disease

Schneider, Susanne A.; Edwards, Mark J.; Cordivari, Carla; Macleod, William N.; Bhatia, Kailash P.

doi:10.1002/mds.21019

Cited by 43 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Successful treatments with BoNT have been reported but no controlled trials are available (Schneider et al, 2006). Higher doses of BoNT may need to be injected in the limb than in hand dystonia because motor control is less refined.…”

Section: Pharmacologymentioning

confidence: 99%

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

et al. 2017

View full text Add to dashboard Cite

The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown. The molecular structure of the large protein complexes that the toxin forms with accessory proteins, which are included in some BoNT type A1 and B1 pharmacological preparations, have been determined. By far the largest effort has been dedicated to the testing and validation of BoNTs as therapeutic agents in an ever increasing number of applications, including pain therapy. BoNT type A1 has been also exploited in a variety of cosmetic treatments, alone or in combination with other agents, and this specific market has reached the size of the one dedicated to the treatment of medical syndromes. The pharmacological properties and mode of action of BoNTs have shed light on general principles of neuronal transport and protein-protein interactions and are stimulating basic science studies. Moreover, the wide array of BoNTs discovered and to be discovered and the production of recombinant BoNTs endowed with specific properties suggest novel uses in therapeutics with increasing disease/symptom specifity. These recent developments are reviewed here to provide an updated picture of the biologic mechanism of action of BoNTs, of their increasing use in pharmacology and in cosmetics, and of their toxicology.

show abstract

Section: Pharmacologymentioning

confidence: 99%

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Parkinsonian orolingual tremor generally responds to antiparkinsonian treatment to the same extent as limb resting tremors. Botulinum toxin has also been reported to be beneficial in Parkinsonian jaw tremor 77…”

Section: Treatment Of Orolingual Tremormentioning

confidence: 99%

Sentinel node navigation surgery versus observation as a management strategy for early tongue carcinoma

Yamauchi¹,

Fujioka²,

Kohno³

2011

Head & Neck

View full text Add to dashboard Cite

show abstract

“…In an open-label pilot study, jaw tremor in three PD patients mainly due to rhythmic activity of the masseter muscles was treated with BoNT injections into the muscles [19]. Botulinum toxin type A in the formulation of DYSPORT, was injected with a mean dosage of 53 U (range: 30-100 U) into each masseter muscle.…”

Section: Jaw Tremormentioning

confidence: 99%