Botulinum toxin A injections in the treatment of axillary hyperhidrosis: a prospective study reviewing quality of life and patient satisfaction in a
            <scp>UK</scp>
            tertiary dermatology centre

Asfour, Leila; Moussa, Anthony; Littlewood, Zoe; Sharif, Jennifer; Newsham, John; O'Donoghue, N. B.; Ogden, Stephanie; McMullen, Emma; Hunter, Hamish J.A.

doi:10.1111/ced.15164

Cited by 2 publications

(5 citation statements)

References 7 publications

(8 reference statements)

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“…Thirty eight to 63 percent of patients with primary palmar HH [ 42 – 44 ] and 89.8% of patients with plantar HH have very poor QoL prior to treatment with sympathectomy [ 19 ]. In two studies, prior to treatment with botulinum toxin, adults with primary HH had a median DLQI of 20 [ 45 ] and 13.5 [ 46 ], indicating severe QoL in patients. The DLQI scores improved to three [ 45 ] and one [ 46 ], respectively, following treatment with chemo-denervation with botulinum toxin.…”

Section: Resultsmentioning

confidence: 99%

“…In two studies, prior to treatment with botulinum toxin, adults with primary HH had a median DLQI of 20 [ 45 ] and 13.5 [ 46 ], indicating severe QoL in patients. The DLQI scores improved to three [ 45 ] and one [ 46 ], respectively, following treatment with chemo-denervation with botulinum toxin. The impact of head and forehead HH has been poorly investigated in the literature.…”

Section: Resultsmentioning

confidence: 99%

“… Kouris et al 2014 [ 45 ] HDSS, DLQI Pre-post interventional study 119 Patients with primary HH have a median DLQI of 20, indicating severe QoL, which improved to 3 following treatments with botulinum toxin. Asfour et al 2022 [ 46 ] HDSS, DLQI Pre-post interventional study 40 Patients with axillary HH had a median HDSS score of three and a DLQI score of 13.5 (indicating a very large effect of HH on QoL). The median HDSS and DLQI score improved to one following treatment with botulinum toxin.…”

Section: Methodsmentioning

confidence: 99%

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The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

2023

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Hyperhidrosis is a condition of excessive sweating, which can have profound physical and mental effects. Hyperhidrosis is a significantly impactful and distressing illness that warrants equal attention as other more well-known dermatologic conditions. However, because of a lack of awareness among the public, stigma, and difficulty with access to treatments (due to cost or insurance coverage), patients are less likely to be diagnosed and treated. In hyperhidrosis, quality-of-life surveys can be useful for determining the magnitude of symptoms and to evaluate treatment outcomes. The purpose of this study was to conduct a narrative literature review to investigate the impact of hyperhidrosis on quality of life. A total of 49 articles investigating the impact of primary hyperhidrosis on quality of life were selected for the review. Hyperhidrosis is a potentially debilitating illness that affects multiple domains of patients’ lives including their psychological, physical, and social functioning. Despite the significant impacts, patients with hyperhidrosis are less likely to seek care. Here, we explore these impacts, and disparities in care, in more detail.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

2023

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“…Adjunctive therapy to the laser included the use of botulinum toxin type A, chemical cauterization with silver nitrate, and an Alexandrite laser. Botulinum toxin type A has been shown to improve HS patients' quality of life and decrease symptoms of the disease, which can be life-changing for them 8,23–25 . It works by reducing sweat secretion mediated by overactive cholinergic nerve fibers by blocking acetylcholine release and by reducing hyperhidrosis, causing a reduction of moist environments for bacterial proliferation and preventing the rupture and diffusion of follicular material through the dermis, which diminishes the promotion of inflammation and sinus tract formation 8,25–27 .…”

Section: Discussionmentioning

confidence: 99%

“…Botulinum toxin type A has been shown to improve HS patients' quality of life and decrease symptoms of the disease, which can be life-changing for them. 8,[23][24][25] It works by reducing sweat secretion mediated by overactive cholinergic nerve fibers by blocking acetylcholine release and by reducing hyperhidrosis, causing a reduction of moist environments for bacterial proliferation and preventing the rupture and diffusion of follicular material through the dermis, which diminishes the promotion of inflammation and sinus tract formation. 8,[25][26][27] Chemical cauterization with silver nitrate is used to treat open wounds to cauterize hemostasis after debridement and hypergranulation of tissue.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Review of Laser Therapy for Treatment of Hidradenitis Suppurativa

Fortoul,

Macias Martinez,

Ventura Rodriguez

et al. 2023

Ann Plast Surg

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Purpose Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful and foul-smelling cystic nodules and sinus tracts in the apocrine gland-bearing regions. The treatment options include topical, intralesional, systemic, and surgical modalities. Currently, the most novel therapy is laser therapy to provide localized treatment without systemic adverse effects. However, data regarding patient outcomes after laser treatment are limited because of the low prevalence of this disease. This study aimed to evaluate the efficacy of laser therapy as a treatment modality for patients with HS. Methods A retrospective review cohort analysis of patients with HS undergoing laser treatment between 2016 and 2021 was conducted. Patient demographics, lesion location(s), Hurley stage, age of onset and diagnosis, treatment length, type, outcomes, and complications were analyzed. Results Ninety-four patients met the inclusion criteria; on average, patients were treated with 5.8 laser sessions for 14.8 months with no complications and minor blood loss. Hidradenitis suppurativa progression commonly starts during puberty, with a median onset of 13.8 years and diagnosis of HS at 16.2 years. All patients (n = 94) showed an improvement in HS disease severity: 59.6% completed treatment, 12.0% are currently undergoing treatment, and 26.0% were lost to follow-up. Conclusions Laser therapy is an effective and safe therapy for HS leading to improved quality of life and should be considered in the treatment and management of HS.

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Botulinum toxin A injections in the treatment of axillary hyperhidrosis: a prospective study reviewing quality of life and patient satisfaction in a UK tertiary dermatology centre

Cited by 2 publications

References 7 publications

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

A Retrospective Review of Laser Therapy for Treatment of Hidradenitis Suppurativa

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