Botulinum Toxin A Can Positively Impact First Impression

Dayan, Steven H.; Lieberman, Elliot; Thakkar, Nirav; Larimer, Karen; Anstead, Amy S.

doi:10.1097/00042728-200806001-00009

Cited by 2 publications

(2 citation statements)

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“…Treatment with onabotulinumtoxinA (BOTOX Cosmetic, Allergan, Inc., Irvine, CA) has been shown to reduce the severity of glabellar lines significantly, with outcomes that patients find cosmetically satisfying 4,5 . First impressions have also been improved when used to treat forehead wrinkles and crow's feet 6 . Since the U.S. Food and Drug Administration approved onabotulinumtoxinA for cosmetic use in 2002, it has become the most popular cosmetic procedure in the United States 7–12 .…”

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confidence: 99%

Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA

Dailey

Philip²,

Tardie³

2011

Dermatologic Surgery

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confidence: 99%

Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA

Dailey

Philip²,

Tardie³

2011

Dermatologic Surgery

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“…Skin aging is influenced by both internal (changes in hormonal status and local immune system [1]) and external (ultraviolet exposure and effects of the regulation of the hypothalamic-pituitary-adrenal axis [1,2]) factors. The human face is constantly exposed to the outside world, influencing personal impressions [3]. Various age-related facial changes are noticeable [4], particularly periorbital area changes [5].…”

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confidence: 99%

Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study

Watanabe,

Tahara,

Hirano

2023

JMIR Dermatol

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Background Placental extract has been mostly used in skin care for cosmetic purposes. However, the use of various placental extracts has been limited due to the lack of established and effective application methods. Objective In this study, we investigated the antiwrinkle effect of a cream formulation—LNC wrinkle eye cream (LNC-EC)—containing horse placental extract as the main ingredient. Methods A total of 24 healthy women, aged 37-54 years, with wrinkle grades 1-3, were treated with LNC-EC for 2 weeks. The cream was applied on one-half of the participants’ faces, and the results were compared with the untreated half of the face. Results Visual inspection, using the wrinkle grade standard, showed that the area treated with LNC-EC had a significantly lower wrinkle grade than the untreated area when comparing before and after the application of LNC-EC. In addition, replica analysis showed a significant reduction in both the maximum wrinkle width and the number of wrinkles in the LNC-EC–treated area in comparison to the untreated area before and after the application. These results suggest that LNC-EC has an antiwrinkle effect on the corners of the eyes based on parameters like the maximum wrinkle width and the number of wrinkles. Conclusions LNC-EC, with horse placental extract as its main ingredient, was shown to be effective in improving wrinkles at the eye corners, presumably due to a reduction in the maximum wrinkle width and the number of wrinkles. Interpretation of the results is limited because this study was conducted only in the intervention group. A randomized controlled trial with a placebo control group is necessary to verify the antiwrinkle effects of horse placental extract.

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Botulinum Toxin A Can Positively Impact First Impression

Cited by 2 publications

References 5 publications

Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA

Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA

Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study

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