Botulinum toxin A and the cutaneous nociception in humans: A prospective, double-blind, placebo-controlled, randomized study

Botulinum toxin type A selectivity for certain types of pain is associated with capsaicin-sensitive neurons

“…Recently, it was proposed that BoNT serotype B reduces spinal substance P release from TRPV1-expressing neurons in mice [38]. -BoNT/A and suppression of TRPV1-expressing neurons (evoked by denervation of TRPV1-expressing neurons, or TRPV1 antagonists) do not affect acute mechanical thresholds [4,5,14,15,32,43,44,59]. In present study we observed preserved acute mechanical sensitivity upon either BoNT/A treatment or denervation of capsaicin-sensitive primary afferents (Fig.…”

“…In contrast to classical analgesics such as opioids, BoNT/A does not alter the acute nociceptive thresholds, but it selectively reduces the allodynic and hyperalgesic responses in certain pain conditions [4,5,14,15]. We previously discovered that the antinociceptive activity of BoNT/A is mediated by its axonal transport to central sensory nociceptive nuclei [7,21,39].…”

“…BoNT/A is not active in all forms of pain and does not alter normal acute sensory thresholds [4,5,14,15]. We hypothesized that the antinociceptive effects of BoNT/A might be mediated by capsaicin-sensitive transient receptor potential vanilloid (TRPV1)-expressing neurons, since this type of neurons does not convey acute responses to innocuous or noxious stimuli [12,44].Therefore, we studied formalin-induced hypersensitivity and the occurrence of cleaved SNAP-25 in TNC after peripheral BoNT/A alone or in combination with capsaicininduced desensitization.…”

Einsatz intra- bzw. subkutaner Botulinumtoxine bei Post-Zoster-Neuralgie

“…Eine subkutane oder intradermale Administration von BoNT führt zu keiner Veränderung der mechanischen oder thermischen Schmerzschwellen [6,50]. Bei Patienten mit diabetischer Polyneuropathie führte eine Verabreichung von BoNT allerdings zu einer signifikanten Verbesserungdermechanischenund taktilen Wahrnehmungsschwellen [8].…”

Síndrome de dolor miofascial del suelo pélvico: una patología urológica muy frecuente

“…Disminuye el tono muscular de los mú sculos contracturados 47 . Sherin et al en un estudio piloto tratan con inyecciones de bó tox a 12 mujeres con dolor pé lvico cró nico asociado con espasmo del elevador del ano.…”