Bottom-Up Fabrication of Multilayer Enteric Devices for the Oral Delivery of Peptides

Nemeth, Cameron L.; Lykins, William R.; Tran, Huyen T. T.; El-Sayed, Mohamed; Desai, Tejal A.

doi:10.1007/s11095-019-2618-3

Cited by 22 publications

(30 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the key goals with biologic delivery in the intestine is to protect the drug cargo from the harsh environment of the stomach prior to improving bioadhesion and controlled release of insulin within the intestines. Recently, Nemeth et al reported on the loading of Eudragit® microwell devices via picoliter inkjet 3D printing for oral drug delivery applications [204]. This method provides a high throughput and reproducible means of loading biologics such as insulin into flat devices to increase tissue retention and improve oral drug delivery.…”

Section: Intestines and Colon Deliverymentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

Self Cite

152

View full text Add to dashboard Cite

Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

show abstract

Section: Intestines and Colon Deliverymentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

Self Cite

152

View full text Add to dashboard Cite

show abstract

“…Later, drug loading and capping process were all conducted in a single platform using a picoliter dispenser by inkjet printing polymer/drug solutions on a silanized silicon substrate (Fig. 3B) [36]. To do so, the authors took advantage of the coffee-ring effect by deposition of water droplets with 5% (w/v) Eudragit® FS 30D on a hydrophobized substrate.…”

Section: Passive Microdevices For Oral Drug Delivery: Opportunities Amentioning

confidence: 99%

“…To do so, the authors took advantage of the coffee-ring effect by deposition of water droplets with 5% (w/v) Eudragit® FS 30D on a hydrophobized substrate. Although Eudragit® polymers are non-biodegradable, they are FDA approved for pH sensitive release of drugs in the GI tract [36]. So far, these devices have not been tested in animals.…”

Section: Passive Microdevices For Oral Drug Delivery: Opportunities Amentioning

confidence: 99%

See 1 more Smart Citation

Orally ingestible medical devices for gut engineering

Mandsberg

Christfort

Kamguyan

et al. 2020

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro-to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.

show abstract

“…Oral drug delivery remains the preferred administration route due to ease of use, flexibility and patient compliance [1]. Despite many advances in oral delivery systems [2][3][4], the design of 'the ideal delivery device' is still widely discussed and depends on the application.…”

Section: Introductionmentioning

confidence: 99%

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Christfort

Guillot²,

Melero³

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on in vitro release, in situ mucoadhesion and in situ absorption of amoxicillin. Additionally, the mucoadhesion of empty cylindrical microcontainers with and without pillars on the top surface was investigated. From the microscopy analysis of the colon sections after the in situ study, it was evident that a significantly higher percentage of cubic microcontainers than cylindrical microcontainers adhered to the intestinal mucus. Furthermore, the absorption rate constants and blood samples indicated that amoxicillin in cubic microcontainers was absorbed more readily than when cylindrical or triangular microcontainers were dosed. This could be due to a higher degree of mucoadhesion for these particular microcontainers.

show abstract

Bottom-Up Fabrication of Multilayer Enteric Devices for the Oral Delivery of Peptides

Cited by 22 publications

References 43 publications

Micro and nanoscale technologies in oral drug delivery

Micro and nanoscale technologies in oral drug delivery

Orally ingestible medical devices for gut engineering

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Contact Info

Product

Resources

About