Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects

Vanuzzo, Diego; Pilotto, Lorenza; Lombardi, Rossana; Lazzerini, Guido; Carluccio, Marisa; Diviacco, Silvia; Quadrifoglio, Franco; Danek, G.M.; Gregori, Darío; Fioretti, P.; Cattaneo, Marco; Caterina, Raffaele De

doi:10.1093/eurheartj/ehl470

Cited by 33 publications

(27 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Homocysteine metabolism is dependent on the concentrations of B vitamins; that is, folate, serum vi- tamin B12 and vitamin B6 status, which may play some part in the cardiovascular events mediated by hCys plasma concentrations [49]. Low circulating folate and vitamin B12 concentrations lead to high fasting total homocysteine concentrations in humans [50].…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria

Heidarian¹,

Amini²,

Parham³

et al. 2009

Rev Diabet Stud

View full text Add to dashboard Cite

■ AbstractOBJECTIVES: Elevated homocysteine levels are considered to be an independent risk factor for cardiovascular complications in diabetic patients. The aim of this study was to find out if zinc supplementation improves homocysteine levels, which may exert vascular-protective effects in type 2 diabetes subjects with microalbuminuria. METHODS: In a randomized, double-blind, controlled, crossover study, 50 type 2 diabetic patients with microalbuminuria were subdivided into two groups and supplemented with 30 mg/d of zinc (group 1) or placebo (group 2) for three months with a fourweek wash out period. Serum creatinine, vitamin B 12 , folate, fasting plasma glucose, HbA1c, lipid profiles, zinc, homocysteine levels and random urine albumin were measured before and after the first and second phase of the study in all participants. RESULTS: Mean serum zinc was significantly increased after zinc supplementation (from 76 ± 16 µg/dl to 93 ± 20 µg/dl; p < 0.05), while there was no change in the placebo group (75 ± 16 µg/dl to 75 ± 15 µg/dl). With zinc supplementation, homocysteine levels reduced significantly (from 13.71 ± 3.84 µmol/l to 11.79 ± 3.06 µmol/l; p < 0.05), which did not occur on placebo (from 12.59 ± 2.13 µmol/l to 13.36 ± 2.03 µmol/l). Simple regression was used to show a positive correlation between urine albumin excretion and serum homocysteine (r = 0.37, p = 0.023). Vitamin B 12 and folate levels increased significantly in patients who received zinc in comparison to those who received placebo. A negative correlation was observed between homocysteine and vitamin B 12 concentration (r = -0.36, p = 0.025). CON-CLUSION: Zinc supplementation reduced serum homocysteine and increased vitamin B 12 and folate concentrations in type 2 diabetic patients with microalbuminuria.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria

Heidarian¹,

Amini²,

Parham³

et al. 2009

Rev Diabet Stud

View full text Add to dashboard Cite

show abstract

“…We observed that Hcy plasma concentration decreased significantly after the CB 6 6 has an important role in the prevention of atherosclerosis regardless of the reduction of plasma homocysteine concentration, but the exact mechanism responsible for this remains unclear [27][28][29] . One plausible Heart function, oxidative stress and vitamin B 6 mechanism is the endogenous production of H2S by the transsulfuration pathway that mediates cysteine production from catabolism of Hcy.…”

Section: Discussionmentioning

confidence: 83%

Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A prospective study of the population from north-eastern Italy confirmed that in long -term follow-up, Hcy and vitamin B 6 are the best prognostic markers of coronary and cerebral events in healthy individuals. 30 It has been shown that supplementation with folic acid not only lowered the Hcy level but also effectively reduced the risk of stroke by 18% in individuals with no history of stroke. 11 The results of a meta-analysis conducted by Lee et al 12 indicated that folic acid supplementation did not have a major effect on averting stroke.…”

Section: Methodsmentioning

confidence: 99%

Homocysteine and metabolic risk factors in individuals with family history of premature ischemic stroke

Mierzecki¹,

Bukowska²,

Kłoda³

et al. 2013

Polish Archives of Internal Medicine

View full text Add to dashboard Cite

282IntroductIon Stroke is one of the main causes of death in the adult population.1 Family history of stroke is recognized as an independent risk factor for cardiovascular disease (CVD). 2 According to Framingham prospective studies, a family history of stroke before the age of 65 years increases the risk of this condition in progeny 2-to 3-fold. This correlation is independent of conventional risk factors for stroke such as age, sex, systolic blood pressure (SBP), arterial hypertension, diabetes, tobacco smoking, coronary events, or the presence of atrial fibrillation or left ventricular hypertrophy. 3 While not excluding the potential genetic factors, the underlying causes of family risk of stroke should be sought in the interaction of many environmental factors. One of such factors might be elevated homocysteine (Hcy) concentrations resulting from chronic B-group vitamin deficiency (folic acid, vitamins B 6 and B 12 ) in diet. Such an association has been indicated in the studies on the Japanese population, showing that low intake of B-group vitamins has an effect on the increase in the risk of stroke.4 Moreover, it has been shown that the Hcy concentration in the Polish population is independently associated with all-cause mortality and AbstrActIntroductIon Family history of stroke is an independent risk factor for cardiovascular disease (CVD). objEctIvEs The aim of this study was to evaluate selected metabolic risk factors and an association between the interaction of family history of premature ischemic stroke (PIS) and homocysteine (Hcy) levels with other risk factors in individuals with family history of PIS.

show abstract

Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects

Abstract: tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events.

Cited by 33 publications

References 37 publications

Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria

Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria

Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

Homocysteine and metabolic risk factors in individuals with family history of premature ischemic stroke

Contact Info

Product

Resources

About