Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females

Wu, Chao; Ding, Yu; Chen, Biqing; Gao, Yayue; Wang, Qian; Wu, Zhemeng; Lü, Ling; Luo, Lu; Zhang, Changxin; Bao, Xiaohan; Yang, Pengcheng; Fan, Langchen; Lei, Ming; Li, Liang

doi:10.1016/j.neuroscience.2019.02.001

Cited by 15 publications

(9 citation statements)

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“…However, this attentional modulation of PPI disappeared with a discrete prepulse of 20 ms (Poje and Filion, 2021 ). Previous studies using longer discrete prepulse (50–150 ms) have shown that PPI can be modulated by fear conditioning and perceptual separation (Li et al, 2009 ; Du et al, 2011 ; Lei et al, 2014 , 2018 ; Wu et al, 2019 ). This study found that PPI with attended long discrete prepulse (150 ms) was larger than the PPI with ignored discrete prepulse at a lead interval of 270 ms.…”

Section: Discussionmentioning

confidence: 97%

“…In Filion's PPI protocol, only with 120 ms lead interval, PPI can be enhanced when attended. Long lead intervals (100–270 ms) have been approved to be efficient in eliciting modified PPI in other studies (Du et al, 2011 ; Lei et al, 2014 , 2018 ; Wu et al, 2019 ). This study demonstrated that the attentional modulation of PPI occurs when the lead interval is set at 270 ms.…”

Section: Discussionmentioning

confidence: 99%

“…One possible explanation is that when the prepulse is discrete and the duration is 20 ms, participants cannot discriminate tone frequency within 20 ms for the target and nontarget tones to have different effects on PPI. Previous studies using longer discrete prepulse (50-150 ms) have shown that PPI can be modulated by fear conditioning and perceptual separation in animals and human models (Li et al, 2009;Du et al, 2011;Lei et al, 2014Lei et al, , 2018Wu et al, 2019). Yet, it is unclear whether long discrete prepulse could elicit an attentional effect on PPI.…”

Section: Introductionmentioning

confidence: 99%

“…For example, PPI modulated by fear conditioning occurs at the lead interval of 100 ms (Du et al, 2011 ; Lei et al, 2014 ). PPI was modulated by perceptual separation at the lead interval of 210 and 270 ms (Lei et al, 2018 ; Wu et al, 2019 ), and PPI with different modalities for the prepulse and the startle stimulus was modulated by attention at a lead interval of 300 ms (Bradley et al, 1993 ). Thus, it would be of interest to investigate whether PPI induced by discrete prepulse can be modulated by attention with long lead intervals.…”

Section: Introductionmentioning

confidence: 99%

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Neural Correlates of Attentional Modulation of Prepulse Inhibition

Lei

Ding

Meng

2021

Front. Hum. Neurosci.

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Prepulse inhibition (PPI) refers to the suppression of the startle reflex when the intense startling stimulus is shortly (20–500 ms) preceded by a weak non-startling stimulus (prepulse). Although the main neural correlates of PPI lie in the brainstem, previous research has revealed that PPI can be top-down modulated by attention. However, in the previous attend-to-prepulse PPI paradigm, only continuous prepulse but not discrete prepulse (20 ms) could elicit attentional modulation of PPI. Also, the relationship between the attentional enhancement of PPI and the changes in early cortical representations of prepulse signals is unclear. This study develops a novel attend-to-prepulse PPI task, when the discrete prepulse is set at 150 ms at a lead interval of 270 ms, and reveals that the PPI with attended prepulse is larger than the PPI with ignored prepulse. In addition, the early cortical representations (N1/P2 complex) of the prepulse show dissociation between the attended and ignored prepulse. N1 component is enhanced by directed attention, and the attentional increase of the N1 component is positively correlated with the attentional enhancement of PPI, whereas the P2 component is not affected by attentional modulation. Thus, directed attention to the prepulse can enhance both PPI and the early cortical representation of the prepulse signal (N1).

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neural Correlates of Attentional Modulation of Prepulse Inhibition

Lei

Ding

Meng

2021

Front. Hum. Neurosci.

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“…A review of PPI found that healthy young women, regardless of when they were tested during their menstrual cycle, had lower PPI than healthy young men (Kumari, 2011). Menstrual cycle of women was also shown to be an influencing factor which should be considered in experiments (Wu et al, 2019). More studies are required to explore the relationship between gender and PPI in CHR groups.…”

Section: Discussionmentioning

confidence: 99%

Pre‐pulse inhibition deficits in individuals at clinical high‐risk for psychosis: A systematic review and meta‐analysis

Mao

et al. 2020

Early Intervention Psych

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Aim: Neurophysiological markers of schizophrenia may help identify individuals who are at an increased risk of developing psychosis. As an operational measure of sensorimotor gating, pre-pulse inhibition (PPI) deficit has been investigated in clinical highrisk (CHR) individuals. In this study, we performed a systematic review and metaanalysis of studies that investigated PPI in CHR individuals.Methods: Relevant studies published as of July 2019 were retrieved from the PubMed, Cochrane, Embase, PscyINFO, EBSCO and Chinese databases. PPI was evaluated by calculating the standard mean differences (SMDs) between CHR individuals and healthy controls (HC) in meta-analysis. Quality of studies was assessed using the Newcastle-Ottawa Scale. I 2 index was used to assess heterogeneity and Egger's test was used to assess publication bias.Results: Eight studies were found to be eligible. The meta-analysis included five studies with a combined study population of 184 CHR subjects and 161 HC. CHR individuals showed lower PPI levels compared to HC in 120 ms inter-stimulus interval or stimulus onset asynchrony paradigm (P = .491, SMD = −0.62). No significant heterogeneity was observed in 120 ms PPI paradigm (χ 2 = 3.41, P = .491, I 2 = 0.0%). Conclusion:CHR individuals had lower PPI level compared to HC in 120 ms paradigm, which were relatively stable and significant. The results indicate the presence of information processing and inhibitory problems prior to the development of fullblown psychosis. PPI may be clinically used as an objective indicator to supplement the understanding of CHR individuals. K E Y W O R D Sclinical high-risk for psychosis, healthy controls, meta-analysis, pre-pulse inhibition, systematic review | INTRODUCTIONEarly detection and intervention for schizophrenia is an increasing area of interest in schizophrenia research. The concept of clinical highrisk (CHR) state, which was aimed to describe people with potential prodromal symptoms, has evolved to include the prepsychotic phase (Fusar-Poli et al., 2013). There are two broad sets of criteria to diagnose the CHR state: ultra-high risk (UHR) and basic symptom (BS) criteria (Olsen & Rosenbaum, 2006). The BS criteria can identify an earlier prodromal state whereas the UHR criteria tend to reflect a somewhat later

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Effects of prepulse format and lead interval on the assessment of automatic and attention-modulated prepulse inhibition

Poje

Filion

2021

Cogn Process

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Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females

Cited by 15 publications

References 66 publications

Neural Correlates of Attentional Modulation of Prepulse Inhibition

Neural Correlates of Attentional Modulation of Prepulse Inhibition

Pre‐pulse inhibition deficits in individuals at clinical high‐risk for psychosis: A systematic review and meta‐analysis

Effects of prepulse format and lead interval on the assessment of automatic and attention-modulated prepulse inhibition

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