Both the shell of the nucleus accumbens and the central nucleus of the amygdala support amphetamine self-administration in rats

Chevrette, Jessica; Stellar, James R.; Hesse, Gary W.; Markou, Athina

doi:10.1016/s0091-3057(01)00686-4

Cited by 32 publications

(20 citation statements)

References 19 publications

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“…For example, inhibition of DA transmission within the amygdala reduces fear-potentiated startle (Greba & Kokkinidis, 2000), the retrieval of conditioned-fear associations (Nader & LeDoux, 1999), and has a general anxiolytic effect (de la Mora et al, 2005). On the other hands, rats self-administer damphetamine directly in the central nucleus of the amygdala (Chevrette et al, 2002), while DA transmission in the basolateral amygdala contribute to the establishment and reinstatement of instrumental and associative reward learning (Zarrindast et al, 2003;Andrzejewski et al, 2005;Alleweireldt et al, 2006). In sum, both positive and negative emotional behavioral dispositions appear to be stimulated by DA in the amygdala.…”

Section: Microinjections and Lesion Studiesmentioning

confidence: 99%

“…DA projections to the shell are more sensitive to a great variety of stimuli, including drugs of abuse (Pontieri et al, 1995), restraint and pharmacological stress (Deutch & Cameron, 1992;Horger et al, 1995;Kalivas & Duffy, 1995;, food, and novel stimuli or environments (Rebec et al, 1997;Rebec, 1998;Barrot et al, 2000). Moreover, microinjections of DA drugs into the medial shell, but not the core, support instrumental behaviors and CPP (Carlezon & Wise, 1996;Ikemoto et al, 1997;Chevrette et al, 2002;Sellings & Clarke, 2003). It is generally accepted that the shell is involved in mediating the rewarding effects of psychostimulants (Parkinson et al, 1999;RoddHenricks et al, 2002;Ito et al, 2004), but there is less agreement concerning the psychomotor activating effects of these drugs.…”

Section: The Nacc Core/shell Distinctionmentioning

confidence: 99%

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Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

516

294

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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning. The affective neuroethological perspective presented here, views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.A description of the anatomical framework in which the ML system is embedded is followed by the argument that the SEEKING disposition emerges through functional integration of ventral basal ganglia (BG) into thalamocortical activities. Filtering cortical and limbic input that spread into BG, DA transmission promotes the "release" of neural activity patterns that induce active SEEKING behaviors when expressed at the motor level. Reverberation of these patterns constitutes a neurodynamic process for the inclusion of cognitive and perceptual representations within the extended networks of the SEEKING urge. In this way, the SEEKING disposition influences attention, incentive salience, associative learning, and anticipatory predictions.In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive drive to persistent craving depending on the intensity of the affect. The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug seeking behaviors.

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Section: Microinjections and Lesion Studiesmentioning

confidence: 99%

Section: The Nacc Core/shell Distinctionmentioning

confidence: 99%

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

516

294

View full text Add to dashboard Cite

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“…Antagonism or Accumbens DA Depletion: Problems with the General DA/Reward Hypothesis Animals will self-administer stimulants directly into nucleus accumbens, and there is little disagreement with the idea that interference with accumbens DA transmission has profound effects upon stimulant self-administration (Roberts et al, 1977;Caine and Koob, 1994;Chevrette et al, 2002). Of course, there are disagreements as to the precise interpretation of these findings, the possible role of other transmitters or other brain regions, and the possible substrates for nonstimulant drugs of abuse.…”

Section: Preserved Aspects Of Primary Food Reinforcement and Food Motmentioning

confidence: 99%

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Salamone¹,

Correa²,

Mingote³

et al. 2003

J Pharmacol Exp Ther

366

252

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For several decades, it has been suggested that dopamine (DA), especially in nucleus accumbens, mediates the primary reinforcing characteristics of natural stimuli such as food, as well as drugs of abuse. Yet, several fundamental aspects of primary food reinforcement, motivation, and appetite are left intact after interference with accumbens DA transmission. Recent studies have shown that accumbens DA is involved in responsiveness to conditioned stimuli and activational aspects of motivation. In concurrent choice tasks, accumbens DA depletions cause animals to reallocate their choice behavior in the direction of instrumental behaviors that involve less effort. Also, an emerging body of evidence has demonstrated that the effects of accumbens DA depletions on instrumental food-seeking behavior can vary greatly depending upon the task. For example, some schedules of reinforcement are insensitive to the effects of DA depletions, whereas others are highly sensitive (e.g., large fixed ratios). Accumbens DA depletions slow the rate of operant responding, blunt the rate-facilitating effects of moderate-sized ratios, and enhance the rate-suppressing effects of very large ratios (i.e., produce ratio strain). Accumbens DA may be important for enabling rats to overcome behavioral constraints, such as work-related response costs, and may be critical for the behavioral organization and conditioning processes that enable animals to engage in vigorous responses, such as barrier climbing, or to emit large numbers of responses in ratio schedules in the absence of primary reinforcement. The involvement of accumbens DA in activational aspects of motivation has implications for energy-related disorders in psychiatry, as well as aspects of drug-seeking behavior.

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“…Evidence indicating that accumbens DA is important for drug self-administration (e.g., Roberts et al 1977;Caine and Koob 1994;Chevrette et al 2002) does not provide direct support for the hypothesis that this system mediates the primary motivational effects of natural stimuli. The mesolimbic dopamine system is thought to promote behavioral activation, arousal, attention, conditioning, and other functions, and the drugrelated induction of these effects could lead to selfadministration but that does not necessarily mean that the primary function of the system in relation to natural stimuli is "reward" Everitt and Robbins 2005;Robbins and Everitt 2007).…”

mentioning

confidence: 95%

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

et al. 2007

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Both the shell of the nucleus accumbens and the central nucleus of the amygdala support amphetamine self-administration in rats

Cited by 32 publications

References 19 publications

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

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