Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Jungersten, Lennart; Ambring, Anneli; Wall, Björn; Wennmalm, Åke

doi:10.1152/jappl.1997.82.3.760

Cited by 203 publications

(148 citation statements)

References 23 publications

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“…51 In another study conducted by Jungersten, it was determined that the plasma NO 3 levels of the athletes were significantly greater than the sedentary, and also that there was a positive correlation between VO 2 max and basal NOx levels. 19,52 Result of studies indicated that, even though there was no significant difference in terms of basal NO levels between sedentary and exercise groups, there was a significant relationship between aerobic capacities and blood NO levels. These findings may indicate the presence of a vasodilator and metabolic regulator potential that forms through training and can be triggered with exercise, which may have a role of NO in these results.…”

Section: Discussionmentioning

confidence: 98%

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The Physiological Responses to 5000 m Open Water Swimming Exercise in Children

Turgay¹,

Özkol²,

Vural³

et al. 2017

Turkiye Klinikleri J Sports Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Open water swimming (OWS) is an endurance sport. Nitric oxide (NO) is a vasodilator gas, therefore it is related to endurance. Physiological stress levels of OWS on children are unknown. The purposes of this study were to investigate the physiological responses to 5000 m OWS and its relation with serum NOx (nitrite plus nitrate) levels in children. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Trained OWS athletes (9 males and 5 females; age=13.8±1.12 years) participated in the study. Serum NOx, oxidative stress index (OSI): total antioxidant status (TAS)/total oxidant stress status (TOS) ratio, muscle damage markers (MDM): serum creatine kinase (CK), aspartate aminotransferase (AST) activity, leucocyte counts and serum glucose (GLU) levels were determined before and after the OWS. Lactate (La), whole blood glucose (WGLU) analyses were done from the fingertip blood samples and heart rate (HR) was measured after every 1000 m. R Re es su ul lt ts s: : After 5000 m OWS, HR and La levels were recorded as 166 beat/min and 2.95 mM. The results indicated that MDM significantly increased (p<0.01), and OSI significantly decreased however there were no significantly changes in TAS, NOx and serum glucose (GLU) values. Basal NOx levels was only related to CK (r=-0.529, p=0.052), but not other parameters. C Co on nc cl lu us si io on n: : 5000 m OWS exercise induced a moderate physiological stress without any oxidative stress, hypoglycemia and health risk for the investigated parameters risk. Although this exercise did not increase blood NOx levels, the negative relationship between basal NOx and CK parameters may show the anti-inflammatory role of NO during OWS exercises in the children. K Ke ey yw wo or rd ds s: : Swimming; nitric oxide; oxidative stress; stres, physiological Ö ÖZ ZE ET T A Am ma aç ç: : Açık su yüzme (ASY) bir dayanıklılık sporudur. Nitrik Oksit (NO) damar genişletici özelliği nedeniyle, dayanıklılıkla ilişkili bir gazdır. ASY'nin çocuklar üzerindeki fizyolojik etkileri bilinmemektedir. Bu çalışmanın amacı; çocukların 5000 m ASY egzersizine verdikleri fizyolojik cevapları ve bu cevapların serum NOx (Nitrit + nitrat) düzeyleri ile ilişkisini araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya aktif ASY sporcuları (9 erkek, 5 kız; yaş=13,8±1,12 yıl) dâhil edilmiştir. Yüzmeden önce ve sonra serum NOx, oksidatif stres indeksi (OSI): toplam antioksidant statüsü (TAS)/toplam oksidatif stres statüsü (TOS), kas hasarı göstergeleri (KHG): serum kreatinkinaz (KK), aspartat aminotransferaz (AAT) aktiviteleri ve lökosit) ölçümü yapılmıştır. Her 1000 m yüzmenin ardından kalp atımı, el parmak ucu kanından laktat ve tam kan glukoz (WGLU) seviyesi ölçülmüş-tür. B Bu ul lg gu ul la ar r: : 5000 m ASY sonunda ortalama kalp atımı (HR); 166 atım/dk, laktat düzeyi; 2,95 mM olarak bulunmuştur. KHG'nin yükseldiği (p<0,01), TAS, NOx ve serum glikoz (GLU) değerlerinin anlamlı olarak değişmediği fakat OSI'nin düştüğü (p<0,01) tespit ed...

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Section: Discussionmentioning

confidence: 98%

“…18 In addition, it has been found that there is a significant relationship between aerobic fitness level and NO. 17,19 Therefore, increasing NO levels may have a positive effect on physiological stress and OS levels during OWS. NO is synthesized from L-arginine, which is catalyzed by nitric oxide synthase (NOS).…”

mentioning

confidence: 99%

The Physiological Responses to 5000 m Open Water Swimming Exercise in Children

Turgay¹,

Özkol²,

Vural³

et al. 2017

Turkiye Klinikleri J Sports Sci

View full text Add to dashboard Cite

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“…6,33 On exercise treadmill test with modified Bruce protocol, NO concentration also increased to 110.7 AE 58.5 μmol/L (range, 61.0-348.8 μmol/L), but there were no differences of baseline NO concentration before and after exercise treadmill test in all 31 patients (p ¼ 0.157).…”

Section: F2-isoprostane and No Production In Patients Hospitalized Wimentioning

confidence: 90%

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

et al. 2013

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Oxygen, although is highly required for living, can be toxic because it can be easily changed into oxygen free radicals (reactive oxygen species, ROS) and generates oxidative stress. [1][2][3][4][5] This oxidative stress will cause endothelial lesion and will be responded by endothelial cells through nitric oxide (NO) response and immunological response pathway. 6-8 The immunological response begins by increasing cytokines production, activated coagulation factors, and reactivation of platelet in acute thrombotic process. However, acute thrombotic process, which is an initial part of protective mechanism to fix the lesion, often change to become continuous process because of abundance oxidative stress, and then generates various levels of acute coronary syndromes. 3,5 Several studies showed that acute exercise on treadmill test with high intensity Bruce protocol increased oxidative stress because of ROS. 9,10 On the contrary, acute exercise also increased production of NO because of the increment effect of shear stress on endothelial cells. 6,9-15 But, regular exercise Keywords ► acute coronary syndrome ► atherosclerosis ► cardiovascular risk factors ► myocardial infarction ► oxidative stress ► nitric oxide ► cardiac markers ► exercise AbstractModerate-to-high intensity of exercise training within 2 to 3 months decreases oxygen free radicals (reactive oxygen species, ROS) and increases nitric oxide (NO) in outpatients with myocardial infarction. There is no data about the association of ROS and NO after short-term low-intensity exercise training within 5 days in patients hospitalized with acute myocardial infarction (AMI). A total of 32 male patients with AMI were randomized into two groups: 15 patients with short-term low-intensity exercise training within 5 days formed the training group and 17 patients without such exercise training formed the control group. All patients performed exercise treadmill test with modified Bruce protocol before and after the study. F2-isoprostane and NO concentration of the training group increased slightly after modified Bruce exercise treadmill test. Compared with the control group, NO of the training group was also slightly higher. Baseline NO and uric acid were negative predictor variables for F2-isoprostane in all patients hospitalized with AMI, and triglyceride was a positive predictor variable. After the study, physical capacity of the training group was higher; but heart rate and systolic blood pressure were lower significantly. This study showed that short-term low-intensity exercise training for patients hospitalized with AMI did not change ROS and NO productions, but it improved physical capacity and lowered heart rate and systolic blood pressure. NO was negative predictor variable for F2-isoprostane in controlling ROS changes in dynamic compensation mechanism.

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“…This positive relation may help to explain the beneficial effects of physical exercise on cardiovascular health. 6 The basal release of endothelium-derived NO is increased with 4 weeks of home based training in hypercholesterolemic patients, independently of lipid profile modification. This may contribute to the cardiovascular protective effects of exercise training, including reduced blood pressure, which may show that exercise conveys benefit beyond lipid profile modification via elevation in basal NO production.…”

Section: ö öZ Ze Et T Amentioning

confidence: 97%

“…7 It was found that only moderate-intensity aerobic exercise augments endothelium-dependent vasodilation through the increased production of nitric oxide, but not mild or high and that high-intensity exercise possibly increases oxidative stress. 8 In another study, it has been shown that long term different training strategies establish different basal nitrites and lipid peroxidation Turkiye Klinikleri J Med Sci 2012;32 (6) Özkol ve ark.…”

Section: ö öZ Ze Et T Amentioning

confidence: 99%

The Effects of Chronic Aerobic and Anaerobic Exercise on Blood Nitric Oxide Levels

Özkol¹,

Turgay²,

Varol³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : Nitric oxide (NO) is a gas which has vasodilator, antioxidant and metabolic regulator features. The positive effect of aerobic exercise is well known on the production of NO in healthy men. However, the effects of chronic anaerobic exercise on blood NO levels remain unclear. The aim of the present study was to investigate the effects of both chronic aerobic and anaerobic exercise on basal serum nitric oxide (BSNO) levels, and the relationships between BSNO and some aerobic and anaerobic performance parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Three groups participated in the present study, each of them was composed of 11 healthy men with similar physical characteristics. The groups consisted of volleyball players as the anaerobic group (AnG), swimmers as the aerobic group (AeG) with long-term exercise background and volunteers who did not exercise regularly as the control group (CG). BSNO (as total nitrite) analysis was determined in fasting venous blood by using Griess method. Mean power and peak power as the criteria of anaerobic performance were determined by using Wingate test, and lactate minimum speed (LMS) was determined as the criterion of aerobic endurance with the LMS test based on lactate elimination. Finger tip lactate measurements were taken during certain segments of LMS test. R Re es su ul lt ts s: : The BSNO value of the AeG was significantly higher compared to the CG (90.34 vs. 74.39 µM), but it was not different from that of the AnG (80.02 µM). No significant relationships were observed between the BSNO and LMS values in any group. The LMS value of the AeG was significantly greater than that in the CG (11.59 vs. 10.27 km/h). Peak power (13.11 vs. 9.84 w/kg) and mean power (8.55 vs. 7.36 w/kg) were significantly greater in the AnG compared to the AeG. A positive correlation was found between BSNO in the AeG and peak power (r=0.648, p=0.031) in the AeG. C Co on nc cl lu us si io on n: : Based on the results of the present study, it is suggested that regular aerobic exercise may improve blood NO levels while anaerobic exercise does not; nevertheless, NO may play a role in both aerobic and anaerobic adaptations to exercise. K Ke ey y W Wo or rd ds s: : Nitric oxid; lactic acid; exercise; anaerobic threshold Ö ÖZ ZE ET T A Am ma aç ç: : Nitrik oksit (NO) vazodilaör, antioksidan ve metabolik özelliklere sahip bir gazdır. Aerobik egzersizin kan NO düzeylerini iyileştirdiği bilinmektedir. Ancak anaerobik egzersizin kan NO düzeyleri üzerindeki etkisi belirsizdir. Bu çalışmanın amacı; aerobik ve anaerobik egzersiz antrenmanlarının kan NO düzeyleri üzerindeki kronik etkilerinin ve bazal serum NO (BSNO) düzeyi ile bazı aerobik ve anaerobik performans parametreleri arasındaki ilişkilerin araştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya benzer fiziksel özelliklere ve uzun bir antrenman geçmişine sahip üç grup katılmış olup, grupların herbiri sağlıklı 11 erkek gönüllüden oluşmaktadır. Anaerobik g...

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Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Cited by 203 publications

References 23 publications

The Physiological Responses to 5000 m Open Water Swimming Exercise in Children

The Physiological Responses to 5000 m Open Water Swimming Exercise in Children

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

The Effects of Chronic Aerobic and Anaerobic Exercise on Blood Nitric Oxide Levels

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