Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

Levison, Steven W.; Goldman, James E.

doi:10.1016/0896-6273(93)90311-e

Cited by 674 publications

(484 citation statements)

References 52 publications

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“…It enlarges during the peak of gliogenesis, between P5 and P20, and then shrinks but persists into adulthood 23,24 . Although most cells give rise to homogeneous progeny, some SVZ cells originate both oligodendrocytes and astrocytes, and a rare cell will develop into both neurons and glia 25 .…”

Section: Discussionmentioning

confidence: 99%

Semi-quantitative analysis of the effects of cyclosporine on remyelination following gliotoxic injection in the brainstem

Bondan

Martins

Branco

et al. 2011

Arq. Neuro-Psiquiatr.

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The use of cyclosporine (CsA) has shown to induce an increase in the density of oligodendrocytes near remyelinating areas following the injection of ethidium bromide (EB), a demyelinating agent, in the rat brainstem. This study was designed in order to evaluate if CsA has the capacity of increasing remyelination. In this context, a comparison between the final balance of myelin repair in CsA treated and non-treated rats was assessed using a semi-quantitative method developed for documenting the extent and nature of remyelination in gliotoxic lesions. Wistar rats were submitted to intracisternal injection of 10 microliters of 0.1% EB. Some were treated during 31 days with CsA (group III -10 mg/kg/day by 7 days and, thereafter, 3 times a week, with a minimal interval of 48 hours) by intraperitonial route. Others were not treated with CsA (group I). A control group was planned receiving into the cisterna pontis 10 microliters of 0.9% saline solution and following after that the same CsA administration protocol (group II). Results clearly demonstrate that in vivo administration of CsA after EB-demyelinating lesions stimulated oligodendrocyte remyelination (mean remyelination scores of 3.72±0.25 for oligodendrocytes and 1.04±0.39 for Schwann cells) compared to non-treated animals (3.13±0.71 and 1.31±0.62, respectively), although the mechanisms by which this positive CsA effect occurs are unclear.

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Section: Discussionmentioning

confidence: 99%

Semi-quantitative analysis of the effects of cyclosporine on remyelination following gliotoxic injection in the brainstem

Bondan

Martins

Branco

et al. 2011

Arq. Neuro-Psiquiatr.

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“…Spinal cord oligodendrocytes apparently arise only from ventral regions and then migrate dorsally to fill the remainder of the cord (Warf et al, 1991;Noll and Miller, 1993;Pringle and Richardson, 1993;Hall et al, 1996;Ono et al, 1997b;Miller et al, 1999;Sussman et al, 2000). In mammalian brain, oligodendrocytes have been reported to arise from the subventricular zone and migrate to both gray and white matter of the ipsilateral forebrain hemisphere (Levison and Goldman, 1993). As in mammals, chick spinal cord oligodendrocytes have been shown to arise in restricted ventral regions (Ono et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal gradient of oligodendrocyte differentiation in chick optic tectum requires brain integrity and cell‐cell interactions

Galileo¹

2002

Glia

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The development of oligodendrocytes in the chicken optic tectum (OT) was studied in vivo and in vitro by analyzing expression of myelin-associated glycoprotein (MAG) with a monoclonal antibody. MAG ϩ cells first appeared in the anterior OT on embryonic day (E) 12, were present throughout the anterior half on E15, and eventually filled the tectum on E17. This spatiotemporal appearance of MAG ϩ oligodendrocytes resembled two streams of cells entering the OT along the afferent and efferent axonal layers. However, experiments determined that this appearance of MAG immunoreactivity was the result of a gradient of oligodendrocyte differentiation and was not cell migration. First, retroviral vector labeling of OT progenitors in vivo on E3 resulted in labeled oligodendrocytes in late embryos. In addition, pieces of OT from as early as E3 kept in culture for a week developed numerous MAG ϩ oligodendrocytes. Pieces of both anterior and posterior E7 OT developed MAG ϩ oligodendrocytes after 3 days in culture, well ahead of their normal schedule in vivo. BrdU incorporation studies revealed that these cells were not born in culture, but merely differentiated. Monolayer cultures made from dissociated E10 or later OT cells developed MAG ϩ oligodendrocytes, but monolayers made from E7 OT cells did not. These experiments demonstrate that oligodendrocyte progenitors were present in the OT as early as E3, that they could differentiate precociously, and that their normal progressive differentiation in situ must be due to removal of inhibitory constraints rather than the onset of inductive factors. Also, certain cell-cell interactions occur between E7 and E10, which cannot be disrupted if oligodendrocyte differentiation is to occur. GLIA 41:25-37, 2003.

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“…Migration of oligodendrocyte-lineage cells out of transplants of C NS tissue (Lachapelle et al, 1983(Lachapelle et al, -1984 or of immunoisolated cells has been elegantly demonstrated in shiverer mutant mice. In addition, studies on early postnatal mouse brain using retroviral labeling have demonstrated the development of oligodendrocytes from cells that have migrated out of the SVZ (Levison and Goldman, 1993). This migration occurs over the surface of astrocytes, extracellular matrix (EC M) molecules, and in some cases, for example in the optic nerve, also along axonal tracts (Small et al, 1987;Ono et al, 1997).…”

mentioning

confidence: 99%

“…Oligodendrocytes develop from progenitor cells located in the ventricular (VZ) and subventricular zone (SVZ) of the brain (Reynolds and Wilkin, 1988;Levison and Goldman, 1993;Hardy and Friedrich, 1996) and spinal cord (Noll and Miller, 1993;Pringle and Richardson, 1993). To reach the axonal tracts that are myelinated in the late embryonic and early postnatal period, the cells must migrate over extensive distances.…”

mentioning

confidence: 99%

Cell-Surface Glycoprotein of Oligodendrocyte Progenitors Involved in Migration

et al. 1999

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Myelination by oligodendrocytes in the CNS involves the migration to and recognition and ensheathment of axons. These distinct developmental phases of myelination are assumed to involve the interplay of a precisely regulated set of cell adhesion molecules expressed by both neurons and glial cells. These molecules remain largely unelucidated. In this paper we have identified a large (330 kDa) glycoprotein expressed by murine oligodendrocyte progenitor cells in vitro and in vivo that is downregulated as oligodendrocytes mature. Antigen-positive oligodendrocyte progenitor cells purified by panning develop into myelin-associated glycoprotein-positive oligodendrocytes and also adhere to cultured neurons. Polyclonal antibodies directed against the protein reduce the migration of oligodendrocyte progenitor cells. The observations suggest that the AN2 antigen may play a role in early stages of myelination.

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Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

Cited by 674 publications

References 52 publications

Semi-quantitative analysis of the effects of cyclosporine on remyelination following gliotoxic injection in the brainstem

Semi-quantitative analysis of the effects of cyclosporine on remyelination following gliotoxic injection in the brainstem

Spatiotemporal gradient of oligodendrocyte differentiation in chick optic tectum requires brain integrity and cell‐cell interactions

Cell-Surface Glycoprotein of Oligodendrocyte Progenitors Involved in Migration

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