Both maternal care received and genotype influence stress‐related phenotype in female rats

Pan, Pauline; Lawson, Daeria O.; Dudin, Aya; Vasquez, Oscar; Sokolowski, Marla B.; Fleming, Alison S.; McGowan, Patrick O.

doi:10.1002/dev.21770

Cited by 8 publications

(17 citation statements)

References 59 publications

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“…Another caveat is that our study design consisted of two cohorts and we analysed as few as one to two female offspring from a litter. Therefore, we did not analyse differences in behaviour using within‐litter pup rankings as we have carried out previously with a minimum of five female pups in a litter . Nevertheless, our correlational analysis of maternal licking identified findings that were in the direction we predicted from the literature and the interaction between average licking duration and DRD2 genotype was consistent between two different tasks.…”

Section: Discussionmentioning

confidence: 83%

“…Handling can induce changes in maternal care by increased solicitation from the pups, although it is unknown whether it can change maternal care between siblings. Although our research group has used this paradigm in the past and found differences in female offspring stress reactivity, inter‐individual variation in maternal licking could be verified with an undisturbed observation period.…”

Section: Discussionmentioning

confidence: 86%

“…[16][17][18] Other studies, including our own, have demonstrated that mothers also show variation in their maternal licking to different pups within the litter. [19][20][21][22][23][24] We found that total inter-individual LG received is associated with differences in stress reactivity at adulthood. 23,24 The effects of average licking bout length received by individual pups on their later-life behaviour have not been explored.…”

mentioning

confidence: 69%

“…[19][20][21][22][23][24] We found that total inter-individual LG received is associated with differences in stress reactivity at adulthood. 23,24 The effects of average licking bout length received by individual pups on their later-life behaviour have not been explored.…”

mentioning

confidence: 69%

“…However, the effects of early‐life maternal care on later‐life behaviour could be influenced by offspring genotype. We recently reported that adult stress reactivity depends on an interaction between LG received and single nucleotide polymorphisms (SNPs) in genes coding for FK506‐binding protein, glucocorticoid receptor and serotonin transporter . Gene × environment interactions are also known to exist for genes involved in dopamine signalling.…”

Section: Introductionmentioning

confidence: 99%

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Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

Lauby

Chatterjee

Pan

et al. 2019

J Neuroendocrinology

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Rat mothers exhibit natural variations in care and can shape offspring adult behaviour and their maternal care by affecting the dopaminergic system. We explored whether genotype and gene × environment interactions are involved in these processes in nulliparous female offspring. We assessed maternal licking/grooming toward individual female pups during the first week postpartum and dopamine‐related behaviour of the offspring in adulthood. Behaviours explored included strategy shifting, impulsive action and sucrose preference. Single nucleotide polymorphisms in the dopamine receptor 2, dopamine transporter and catechol‐O‐methyltransferase genes were examined in relation to offspring behaviour and baseline dopamine turnover in select brain regions. Dopamine receptor 2 (RS107017253) variation moderated, or interacted with, the relationship between early‐life licking received and behaviour. Specifically, offspring with the A/A genotype showed a significant correlation between early‐life licking received and behaviour. Offspring with the A/G and G/G genotypes did not show this relationship. Dopamine transporter gene variation affected offspring behaviour regardless of early‐life licking received. Our findings suggest that genotype can directly affect dopamine‐related behaviours and alter the sensitivity of offspring to the maternal environment. This could be informative on how maternal care is transmitted between generations of female offspring.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 69%

mentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

Lauby

Chatterjee

Pan

et al. 2019

J Neuroendocrinology

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The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring

et al. 2021

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Introduction Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. Methods We assessed early‐life maternal care received by individual female rat offspring, later‐life maternal care provisioning, and dopaminergic activity in the maternal brain in relation to naturally occurring genetic polymorphisms linked to the dopaminergic system. We also conducted a systematic analysis of other genetic variants potentially related to maternal behavior in our Long‐Evans rat population. Results While we did not find a direct relationship between early‐life licking received and later‐life licking provisioning, this relationship was indirectly affected by dopamine levels in the nucleus accumbens and dependent on variation in the dopamine receptor 2 gene (rs107017253). More specifically, female rat offspring with the A/G genotype showed a positive relationship between average licking received and dopamine levels in the nucleus accumbens of the maternal brain; there was no relationship with female rat offspring with the A/A genotype. The higher dopamine levels in the nucleus accumbens corresponded with higher maternal licking provisioning from postnatal days 2–9. We also discovered and validated several new variants that were predicted by our systematic analysis. Conclusion Our findings suggest that genetic variation influences the relationship between early‐life maternal care received and the dopaminergic system of the maternal brain, which can indirectly influence later‐life maternal care provisioning.

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Uncovering sources of maternal variability: Inherited and environmental contributions to maternal phenotype

Lapp

Moore

2020

Developmental Psychobiology

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Intergenerational patterns of parental behavior, especially maternal behavior, have been observed across mammalian species including humans, non‐human primates, and rodents. These patterns are largely experience‐dependent as opposed to genetically induced, with experiences in early‐life serving an essential role in directing maternal behavior expressed later in life. Environmental conditions can also alter maternal behavior with consequences for offspring neurodevelopment and interactions with the next generation. Here, we describe effects of lineage during developmental environmental disruption using a limited bedding and nesting material manipulation during the first 2 weeks of life. Dams from three lineages were placed in environments containing either abundant nesting material or reduced nesting material. Environmental condition affected eight measures of maternal behavior and dam lineage affected 12 measures of maternal behavior during the first two postnatal weeks. Lineage, condition, and pup sex predicted pup body weight immediately following the manipulation, with lineage accounting for the largest portion of variance in body weight. Although from a limited sample, these data are the first to examine effects of lineage and environment simultaneously and suggest dam lineage may be a better predictor of maternal behavior than current environmental conditions with important implications for pup outcomes.

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Both maternal care received and genotype influence stress‐related phenotype in female rats

Cited by 8 publications

References 59 publications

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring

Uncovering sources of maternal variability: Inherited and environmental contributions to maternal phenotype

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