Both estrogen receptor α and estrogen receptor β agonists enhance cell proliferation in the dentate gyrus of adult female rats

Mazzucco, Christine; Lieblich, Stephanie E.; Bingham, Brenda; Williamson, Martin B.; Viau, Victor; Galea, Liisa A.M.

doi:10.1016/j.neuroscience.2006.05.032

Cited by 140 publications

(115 citation statements)

References 54 publications

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“…Administration of E 2 or the ERβ-SERM, DPN, increased cell proliferation in the hippocampus of adult female rats as did the ERα-SERM, PPT, at the moderate dosing utilized [88]. Interestingly, cell proliferation was reduced with coadministration of DPN and PPT [88]. Furthermore, ERα in the hippocampus has been suggested to influence neuronal morphology by stimulating dendritic branching [89], whereas spatial, hippocampus-dependent learning has been shown to be mediated by both ERα [90][91] and ERβ [82,[92][93].…”

Section: The Role Of Erα (And Erβ) For Functional Effects Of Estogensmentioning

confidence: 88%

“…Proliferating cells can co-express ERα or ERβ and neuronal markers, such as doublecortin, in the hippocampus [86][87][88]. Administration of E 2 or the ERβ-SERM, DPN, increased cell proliferation in the hippocampus of adult female rats as did the ERα-SERM, PPT, at the moderate dosing utilized [88].…”

Section: The Role Of Erα (And Erβ) For Functional Effects Of Estogensmentioning

confidence: 99%

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Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

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The steroid hormone, estradiol (E 2 ), has numerous targets in the central nervous system, including the hippocampus, which plays a key role in cognition and affective behavior. This review focuses on our evidence from studies in rodents that E 2 has diverse mechanisms in the hippocampus for its functional effects E 2 has rapid, membrane-mediated effects in the hippocampus to enhance cognitive performance. Administration of E 2 to the hippocampus of rats for 10 minutes following training enhances performance in a hippocampus-mediated task. Increased cell firing in the hippocampus occurs within this short time frame. Furthermore, administration of free E 2 or an E 2 conjugate, E 2 :bovine serum albumin (BSA), to the hippocampus produces similar performance-enhancing effects in this task, suggesting that E 2 has membrane actions in the hippocampus for these effects. Further evidence that E 2 has rapid, membrane-mediated effects is that co-administration of E 2 and inhibitors of mitogen activated protein kinase (MAPK), rather than intracellular E 2 receptors (ERs) or protein synthesis, attenuate the enhancing effects of E 2 in this task. Despite these data that demonstrate E 2 can have rapid and/or membrane-mediated effects in the hippocampus, there is clear evidence to suggest that intracellular ERs, particularly the β (rather than α) isoform of ERs, may be important targets for E 2 's functional effects for hippocampal processes. Administration of ligands that are specific for ERβ, but not ERα, have enhancing effects on hippocampal processes similar to that of E 2 (which has similar affinity for ERα and ERβ). These effects are attenuated when ERβ expression is knocked down in transgenic models or with central administration of antisense oligonucleotides. Thus, there may be a convergence of E 2 's actions through rapid, membranemediated effects and intracellular ERs and in the hippocampus for these functional effects.

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Section: The Role Of Erα (And Erβ) For Functional Effects Of Estogensmentioning

confidence: 88%

Section: The Role Of Erα (And Erβ) For Functional Effects Of Estogensmentioning

confidence: 99%

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

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“…Females in the high estrogen, proestrous state have higher levels of neurogenesis than males (Galea, 2008;Hojo et al, 2004), a characteristic that is reversed by ovariectomy and in part by treatment with the nonselective ER antagonist ICI 182,780 (Perez-Martin et al, 2003). Both ERa and ERb agonists increase cell proliferation in the DG (Mazzucco et al, 2006). The ERb knockout mice show regional neuronal hypocellularity, especially in the cerebral cortex, suggesting that ERb has a role in developmental and physiologic neurogenesis (Wang et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke

Siegel

Yuan

et al. 2010

J Cereb Blood Flow Metab

121

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Stroke is a leading cause of permanent disability and death. It is well accepted that the principal mammalian estrogen (E2), 17-b estradiol, provides robust neuroprotection in a variety of brain injury models in animals of both sexes. E2 enhances neurogenesis after stroke in the subventricular zone; however, it is unknown if these cells survive long-term or enhance functional recovery. In this study, we examined stroke-induced neurogenesis in male, gonadally intact female, and ovariectomized female mice 2 and 6 weeks after stroke. Treatment with 17-b estradiol increased 5-bromo-2 0 -deoxyuridine-labeled cells at both time points in both the dentate gyrus and subventricular zone; the majority were colabeled with doublecortin at 2 weeks and with NeuN at 6 weeks. Stroke-induced neurogenesis was reduced in estrogen receptor knockout mice, as well as in mice lacking the gene for aromatase, which converts testosterone into E2. Improved behavioral deficits were seen in E2-treated mice, suggesting that E2-induced increases in poststroke neurogenesis contribute to poststroke recovery.

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“…However, in that study, the content was evaluated only during diestrus day in adult rats and in adult noncycling rats in persistent diestrus (Mehra et al, 2005). Interestingly, some agonists of both ER receptor subtypes enhance cell proliferation in dentate gyrus of adult female rats (Mazzucco et al, 2006).…”

Section: Introductionmentioning

confidence: 97%

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Mendoza-Garcés

Mendoza-Rodríguez

Jiménez-Trejo

et al. 2011

The Anatomical Record

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In the hippocampus, estrogens increase dendritic arborization, longterm potentiation, neuroprotection, and participate in many functions related with learning, memory, and affective behaviors. The presence of both estrogen receptors alpha (ERa) and beta (ERb) isoforms has been described in the hippocampus where they play different physiological roles. The aim of this study was to investigate, by using both techniques immunohistochemistry and Western Blot, the expression pattern of ERa and ERb in the hippocampus of the rat along the estrous cycle. Western blot analysis was used to confirm the specificity of the antibodies used against ERa and ERb and its relative content in the hippocampus. Results from immunohistochemical studies indicate that ERb expression increased more than the ERa in CA1 and CA3 regions during all phases of the estrous cycle. ERb immunoreactivity was mainly located in the nucleus and predominantly expressed in CA1 during estrous and metestrus, and in CA3 during diestrus. ERa was more abundant during estrous in comparison to other phases of the cycle in CA1 region, while it was more abundant during metestrus in CA3. Interestingly, the immunolocalization of ERa subtype was both cytoplasmic and nuclear. The overall results indicate that there is a differential expression, cellular localization, and distribution of both ER subtypes in CA1 and CA3 regions, suggesting different roles for these two receptors in the hippocampus along the estrous cycle. Anat Rec, 294:1913Rec, 294: -1919Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Both estrogen receptor α and estrogen receptor β agonists enhance cell proliferation in the dentate gyrus of adult female rats

Cited by 140 publications

References 54 publications

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

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