Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis

Bae, Jung Min; Kim, Y.‐S.; Choo, Eun Ho; Kim, M.‐Y.; Lee, J.Y.; Kim, H.‐O.; Park, Y.M.

doi:10.1111/jdv.16830

Cited by 18 publications

(13 citation statements)

References 43 publications

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“…It is likely that UV light has cardiometabolic benefits in both males and females, with body weight, fat mass and adiposity limited in both male and female mice exposed to low-dose UV light (135,141,142,145). Similarly, long-term treatment to narrowband UVB (n = 3,229) reduced the risk of cardiovascular and cerebrovascular events in both men and women with vitiligo (compared to those with few or no sessions: HR 0.64, 95% CI 0.52-0.78 for all events; n = 9,687) from Korea, although associations were more significant in females than males (146). There may also be benefits for sun exposure on blood cholesterol levels, with LDL-cholesterol levels reduced in individuals receiving advice to increase their sun exposure in 2 of 4 identified intervention studies (101), and findings from association studies suggest that sun exposure was associated with increases in HDL (high-density lipoproteins)-cholesterol levels (9).…”

Section: Potential Means By Which Uv Light Improves Cardiometabolic Fmentioning

confidence: 99%

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Gorman

Weller

2020

Front. Cardiovasc. Med.

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During the COVID-19 (coronavirus disease of 2019) pandemic, researchers have been seeking low-cost and accessible means of providing protection from its harms, particularly for at-risk individuals such as those with cardiovascular disease, diabetes and obesity. One possible way is via safe sun exposure, and/or dietary supplementation with induced beneficial mediators (e.g., vitamin D). In this narrative review, we provide rationale and updated evidence on the potential benefits and harms of sun exposure and ultraviolet (UV) light that may impact COVID-19. We review recent studies that provide new evidence for any benefits (or otherwise) of UV light, sun exposure, and the induced mediators, vitamin D and nitric oxide, and their potential to modulate morbidity and mortality induced by infection with SARS-CoV-2 (severe acute respiratory disease coronavirus-2). We identified substantial interest in this research area, with many commentaries and reviews already published; however, most of these have focused on vitamin D, with less consideration of UV light (or sun exposure) or other mediators such as nitric oxide. Data collected to-date suggest that ambient levels of both UVA and UVB may be beneficial for reducing severity or mortality due to COVID-19, with some inconsistent findings. Currently unresolved are the nature of the associations between blood 25-hydroxyvitamin D and COVID-19 measures, with more prospective data needed that better consider lifestyle factors, such as physical activity and personal sun exposure levels. Another short-coming has been a lack of measurement of sun exposure, and its potential to influence COVID-19 outcomes. We also discuss possible mechanisms by which sun exposure, UV light and induced mediators could affect COVID-19 morbidity and mortality, by focusing on likely effects on viral pathogenesis, immunity and inflammation, and potential cardiometabolic protective mechanisms. Finally, we explore potential issues including the impacts of exposure to high dose UV radiation on COVID-19 and vaccination, and effective and safe doses for vitamin D supplementation.

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Section: Potential Means By Which Uv Light Improves Cardiometabolic Fmentioning

confidence: 99%

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Gorman

Weller

2020

Front. Cardiovasc. Med.

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“…These data are consistent with new analyses of the Melanoma in Southern Sweden study in which women with low or moderate past sun exposure (assessed by questionnaire including items on deliberate sun bathing, use of a sun bed, and travel for sunny holidays) had a greater risk of being prescribed anti-hypertensive medication by their physician than those with higher sun exposure; the association persisted after adjustment for being a smoker, exercise category, BMI, and education (adjusted OR 1.41, 95% CI 1.3–1.6; adjusted OR 1.15, 95% CI 1.1–1.2, respectively, for low and moderate sun exposure) [ 228 ]. In a recent study from South Korea, there were fewer cardiovascular (adjusted hazard ratio (HR) 0.68, 95% CI 0.49–0.94) and cerebrovascular (adjusted HR 0.60, 95% CI 0.47–0.77) events over 11 years in patients with vitiligo who had received long-term narrowband UV-B phototherapy (≥ 100 sessions) compared with those who had received < 3 phototherapy sessions [ 229 ]. There is accumulating evidence, including from small clinical trials, that UV-A (and possibly UV-B) irradiation influences blood pressure (and cardiovascular disease risk) through release of nitric oxide from stores in skin [ 230 – 232 ].…”

Section: Benefits Of Exposure To Uv Radiationmentioning

confidence: 99%

The effects of exposure to solar radiation on human health

Neale

Lucas

Byrne

et al. 2023

Photochem Photobiol Sci

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This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts. Of particular note, there is new information about the way in which exposure to UV radiation modulates the immune system, causing both harms and benefits for health. The burden of skin cancer remains high, with many lives lost to melanoma and many more people treated for keratinocyte cancer, but it has been estimated that the Montreal Protocol will prevent 11 million cases of melanoma and 432 million cases of keratinocyte cancer that would otherwise have occurred in the United States in people born between 1890 and 2100. While the incidence of skin cancer continues to rise, rates have stabilised in younger populations in some countries. Mortality has also plateaued, partly due to the use of systemic therapies for advanced disease. However, these therapies are very expensive, contributing to the extremely high economic burden of skin cancer, and emphasising the importance and comparative cost-effectiveness of prevention. Photodermatoses, inflammatory skin conditions induced by exposure to UV radiation, can have a marked detrimental impact on the quality of life of sufferers. More information is emerging about their potential link with commonly used drugs, particularly anti-hypertensives. The eyes are also harmed by over-exposure to UV radiation. The incidence of cataract and pterygium is continuing to rise, and there is now evidence of a link between intraocular melanoma and sun exposure. It has been estimated that the Montreal Protocol will prevent 63 million cases of cataract that would otherwise have occurred in the United States in people born between 1890 and 2100. Despite the clearly established harms, exposure to UV radiation also has benefits for human health. While the best recognised benefit is production of vitamin D, beneficial effects mediated by factors other than vitamin D are emerging. For both sun exposure and vitamin D, there is increasingly convincing evidence of a positive role in diseases related to immune function, including both autoimmune diseases and infection. With its influence on the intensity of UV radiation and global warming, the Montreal Protocol has, and will have, both direct and indirect effects on human health, potentially changing the balance of the risks and benefits of spending time outdoors. Graphical abstract

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“… 93 , 94 Interestingly, the use of narrowband UVB phototherapy treatment correlated with a significant decrease in CV and cerebrovascular events. 95 Also, simvastatin, a statin drug, has been tried as a vitiligo treatment, showing beneficial effects, attributed to its antioxidant and immunomodulating effect. 96 Despite these findings, further studies are needed.…”

Section: Other Emergent Cvd-associated Skin Diseasesmentioning

confidence: 99%

Cardiovascular Disease-Associated Skin Conditions

Hojman¹,

Karsulovic²

2022

VHRM

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According to data from the American Heart Association and the World Health Organization, cardiovascular disease (CVD) is the most frequent cause of premature death. Several inflammatory and non-inflammatory skin diseases have been associated with metabolic syndrome and cardiovascular risk (CVR). Here, we classified these conditions into traditionally CVR-associated and those that have been linked to a lesser degree. Psoriasis and hidradenitis suppurativa are commonly associated with CVD, sharing common inflammatory pathways and a higher prevalence of traditional cardiovascular risk factors. Many other diseases could be associated indirectly -with no common pathogenic features with the atheromatous disease -but share a higher prevalence of standard cardiovascular risk and chronic inflammatory state. This review aims to highlight the associated cardiovascular risk that exists for some dermatologic diseases and sensitize cardiologists, dermatologists, and first care providers to implement risk factor control promptly.

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Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis

Cited by 18 publications

References 43 publications

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

The effects of exposure to solar radiation on human health

Cardiovascular Disease-Associated Skin Conditions

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