Both anodal and cathodal transcranial direct current stimulation improves semantic processing

Brückner, Sabrina; Kammer, Thomas

doi:10.1016/j.neuroscience.2016.12.015

Cited by 52 publications

(29 citation statements)

References 37 publications

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“…These results, however, are in line with neuroimaging studies (9), which have demonstrated activation of this area during encoding of faces with emotional expressions. The fact that in this study anodal tDCS has apparently dis- rupted l-DLPFC function is not totally unexpected, since other authors have already pointed out that the usual dichotomy anodal-excitatory and cathodal-inhibitory is not invariably true (15)(16)(17).…”

Section: Discussionsupporting

confidence: 66%

Anodal transcranial direct-current stimulation over the left dorsolateral prefrontal cortex and perception of emotional faces

Brasil‐Neto

Bernardes

Rosa

et al. 2020

Preprint

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The prefrontal cortices have been shown to be engaged in the perception of emotional faces, and imaging studies correlate activation of the left dorsolateral prefrontal cortex (l-DLPFC) with correct identification of emotional expressions. Transcranial direct current stimulation (tDCS)has been shown to modulate cortical function and might influence the perception of emotional faces. Our aim was to evaluate the possible effects of tDCS on a task that required correct identification of emotions represented by human faces presented on a screen. Ten volunteers (ages 18-30; mean = 23.2; SD = 4.3) were evaluated. The experiments were carried out in two 20 minutes stimulation sessions (real and sham tDCS) 4 days apart, at least, to avoid carryover effects, and session orders were randomized. The anode was placed over the l-DLPFC (F3 of the international 10-20 EEG electrode positioning system) and the cathode over the contralateral supraorbital region. Emotional stimuli were 120 consecutive human faces to be verbally classified as "happy", "surprised", "neutral", "angry" or "sad". Real anodal tDCS over the l-DLPFC resulted in significantly longer response times with a trend towards increased error rates, compared to the sham condition. tDCS, emotional stimuli, response timesCorrespondence: jbrasil@unb.br

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Section: Discussionsupporting

confidence: 66%

Anodal transcranial direct-current stimulation over the left dorsolateral prefrontal cortex and perception of emotional faces

Brasil‐Neto

Bernardes

Rosa

et al. 2020

Preprint

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“…At least three other tDCS studies that have used both anodal and cathodal stimulation in the same study have found similar results regardless of the polarity of the current. Both anodal and cathodal stimulation over the cerebellum impaired performance in a working memory task (Ferrucci et al, 2008), improved semantic processing when tDCS was applied over Wernicke's area (Brückner and Kammer, 2017) and reduced the sense of agency when applied over pre-SMA (Cavazzana et al, 2015). It may be that the learning impairment observed in the current study does not depend on a specific direction of change induced by tDCS, but rather any basal deviations (Javadi, 2015).…”

Section: Anodal and Cathodal Tdcs Over Left Pfcmentioning

confidence: 52%

Multi-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention

Greeley

Barnhoorn

Verwey

et al. 2020

Front. Hum. Neurosci.

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Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can facilitate motor learning, but it has not been established how stimulation to other brain regions impacts online and offline motor sequence learning, as well as long-term retention. Here, we completed three experiments comparing the effects of tDCS and sham stimulation to the prefrontal cortex (PFC), M1, and the supplementary motor area complex to understand the contributions of these brain regions to motor sequence learning. In Experiment 1, we found that both left and right PFC tDCS groups displayed a slowing in learning in both reaction time and number of chunks, whereas stimulation over M1 improved both metrics over the course of three sessions. To better understand the sequence learning impairment of left PFC anodal stimulation, we tested a left PFC cathodal tDCS group in Experiment 2. The cathodal group demonstrated learning impairments similar to the left PFC anodal stimulation group. In Experiment 3, a subset of participants from the left PFC, M1, and sham tDCS groups of Experiment 1 returned to complete a single session without tDCS on the same sequences assigned to them 1 year previously. We found that the M1 tDCS group reduced reaction time at a faster rate relative to the sham and left PFC groups, demonstrating faster relearning after a one-year delay. Thus, our findings suggest that, regardless of the polarity of stimulation, tDCS to PFC impairs sequence learning, whereas stimulation to M1 facilitates learning and relearning, especially in terms of chunk formation.

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“…Transcranial direct current stimulation (tDCS) is a non-invasive tool that can reversibly modulate brain activity by applying a weak, constant direct current through the scalp or skull (Nitsche & Paulus, 2000;Dimov et al 2016;Zmigrod et al 2016;Mosayebi Samani et al 2019). Accumulating evidence has demonstrated that polarity-specific tDCS can improve motor performance (Amadi et al 2015;Karok et al 2016), modulate cognitive or perceptual function (Spiegel et al 2012;Spiegel et al 2013;Labbe et al 2016;Price et al 2016;Rosen et al 2016;Weigl et al 2016;Zmigrod et al 2016;Bruckner & Kammer, 2017;Hertenstein et al 2019;Wiegand et al 2019;Xiong et al 2019;Salvi et al 2020), and facilitate learning and memory (Choe et al 2016;Sandrini et al 2016;Van Meel et al 2016;Ke et al 2019;Nissim et al 2019;Gibson et al 2020). Clinical studies showed that tDCS is a potential therapeutic tool for some neurological or psychiatric disorders (Yoon et al 2012;Zobeiri & van Luijtelaar, 2013;Assenza et al 2014;Dhamne et al 2015;Ding et al 2016;Kang et al 2019;Strumila et al 2019;Vigod et al 2019;Cosentino et al 2020;McClintock et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats

Zhao

Ding

Pan

et al. 2020

The Journal of Physiology

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Key points The present study showed that anodal and cathodal transcranial direct current stimulation (tDCS) can respectively increase and decrease the amplitude of visually evoked field potentials in the stimulated visual cortex of cats, with the effect lasting for ∼60–70 min. We directly measured tDCS‐induced changes in the concentration of inhibitory and excitatory neurotransmitters in the visual cortex using the enzyme‐linked immunosorbent assay method and showed that anodal and cathodal tDCS can selectively decrease the concentration of GABA and glutamate in the stimulated cortical area. Anodal and cathodal tDCS can selectively inhibit the synthesis of GABA and glutamate by suppressing the expression of GABA‐ and glutamate‐synthesizing enzymes, respectively. Abstract Transcranial direct current stimulation (tDCS) evokes long‐lasting neuronal excitability in the target brain region. The underlying neural mechanisms remain poorly understood. The present study examined tDCS‐induced alterations in neuronal activities, as well as the concentration and synthesis of GABA and glutamate (GLU), in area 21a (A21a) of cat visual cortex. Our analysis showed that anodal and cathodal tDCS respectively enhanced and suppressed neuronal activities in A21a, as indicated by a significantly increased and decreased amplitude of visually evoked field potentials (VEPs). The tDCS‐induced effect lasted for ∼60–70 min. By contrast, sham tDCS had no significant impact on the VEPs in A21a. On the other hand, the concentration of GABA, but not that of GLU, in A21a significantly decreased after anodal tDCS relative to sham tDCS, whereas the concentration of GLU, but not that of GABA, in A21a significantly decreased after cathodal tDCS relative to sham tDCS. Furthermore, the expression of GABA‐synthesizing enzymes GAD65 and GAD67 in A21a significantly decreased in terms of both mRNA and protein concentrations after anodal tDCS relative to sham tDCS, whereas that of GLU‐synthesizing enzyme glutaminase (GLS) did not change significantly after anodal tDCS. By contrast, both mRNA and protein concentrations of GLS in A21a significantly decreased after cathodal tDCS relative to sham tDCS, whereas those of GAD65/GAD67 showed no significant change after cathodal tDCS. Taken together, these results indicate that anodal and cathodal tDCS may selectively reduce GABA and GLU syntheses and thus respectively enhance and suppress neuronal excitability in the stimulated brain area.

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Both anodal and cathodal transcranial direct current stimulation improves semantic processing

Cited by 52 publications

References 37 publications

Anodal transcranial direct-current stimulation over the left dorsolateral prefrontal cortex and perception of emotional faces

Anodal transcranial direct-current stimulation over the left dorsolateral prefrontal cortex and perception of emotional faces

Multi-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention

Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats

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