Botanical survey, phytochemical investigation, and antibacterial activity of aqueous extract of Enantia polycarpa (DC) Engl. and Diels stem bark against methicillin resistant Staphylococcus aureus (MRSA)

Ambe, Alain S.A.; Guessennd, Nathalie; Etienne, Ouattara Katinan; Konan, Fernique; Kanga, Yao; Béné, Kouadio; Zirihi, Guédé Noël; N’guessan, Kouakou Edouard

doi:10.1007/s10298-016-1057-4

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Also, the stem bark extract of Annickia polycarpa (APE) possesses antioxidant activity mainly by scavenging free radicals 9 . In addition, its antibacterial, antifungal and antitrypanosomal effects have been reported 8,[10][11][12] . Palmatine, a potent anti-inflammatory agent, has been isolated and characterized from the stem bark 13 .…”

Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic toxicity of aqueous stem-bark extract ofAnnickia polycarpa

Lartey,

Nyarko,

Asare-Anane

et al. 2023

Preprint

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Background and aim: The lack of standardization and scientific validation of the use of most plant extracts leads to toxicity problems. The stem bark extract of Annickia polycarpa has been shown to possess antioxidant, antidiabetic, analgesic, and anti-colitis effects. However, nothing is known about the effects of the prolonged use of the extract. Thus, we investigated the acute and sub-chronic toxicity of the aqueous stem bark extract of (APE) in Sprague-Dawley rats. Experimental procedure: The LD50 and sub-chronic toxicity of APE (20 mg/kg, 100 mg/kg, and 500 mg/kg) was studied over 3 months in Sprague-Dawley rats. Serum alkaline phosphatase (ALP), alanine transaminase (ALT), direct bilirubin and creatinine were measured after 3 months of treatment. Hematological analysis and urinalysis were also performed. Also, the effect of APE on blood clotting time and pentobarbital-induced sleeping time were determined at the termination of treatment. Finally, histological analysis was done on the liver, kidney, lung, and heart after hematoxylin-eosin staining of tissue cross-sections at the termination of treatment. Results and conclusion: The LD50 of APE in rats was higher than 5000 mg/kg with no observable signs of toxicity. APE also showed no hematotoxic effect when used consistently for 3 months. Additionally, APE had no adverse effect on the liver and kidney evidenced by a lack of effect on serum biochemical parameters (ALP, ALT, direct bilirubin, and creatinine), urinalysis as well as the tissue morphology of these organs. No adverse morphological effects were also observed with the heart muscle cells. However, APE showed mild selective toxicity to the lung characterized by alveolar space closing, interstitial fibrosis, and alveolar septa thickening. These results indicate that APE is generally non-toxic at the tested doses but shows mild selective pneumotoxicity when used over a long period of time.

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Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic toxicity of aqueous stem-bark extract ofAnnickia polycarpa

Lartey,

Nyarko,

Asare-Anane

et al. 2023

Preprint

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“…Phytochemical studies on E . polycarpa have shown that the bark contained a wide range of alkaloids including tetrahydroisoquinolines, aporphines, protoberberines and saponins . In contrast, none is known about the chemical composition of the essential oil.…”

Section: Introductionmentioning

confidence: 99%

Composition and Chemical Variability of Enantia polycarpa Engl. & Diels Leaf Essential Oil from Côte d'Ivoire

Yapi

Ouattara

Boti

et al. 2018

Chemistry & Biodiversity

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The composition of Enantia polycarpa Engl. & Diels leaf essential oil has been investigated for the first time using a combination of chromatographic and spectroscopic techniques. The compositions of 52 leaf essential oil samples have been subjected to statistical analysis, hierarchical cluster analysis (HCA) and principal component analysis (PCA). Four groups were differentiated, of which the compositions were dominated by β-elemene and germacrene B (Group III, 22/52 samples); germacrene D (Group I, 16/52 samples); β-cubebene (Group IV, 8/52 samples) and by germacrene B and germacrene D (Group II, 6/52 samples). A special attention was brought to the quantification of the thermolabile components, germacrene A, germacrene B and germacrene C, as well as that of their rearranged compounds, β-elemene, γ-elemene and δ-elemene. C-NMR data of β-cubebene have been provided.

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Chemistry and pharmacology of three antiplasmodial traditional medicinal plants from tropical Africa – A review

Sinan

Zengin

Béné

et al. 2019

South African Journal of Botany

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Botanical survey, phytochemical investigation, and antibacterial activity of aqueous extract of Enantia polycarpa (DC) Engl. and Diels stem bark against methicillin resistant Staphylococcus aureus (MRSA)

Cited by 3 publications

References 18 publications

Acute and sub-chronic toxicity of aqueous stem-bark extract ofAnnickia polycarpa

Acute and sub-chronic toxicity of aqueous stem-bark extract ofAnnickia polycarpa

Composition and Chemical Variability of Enantia polycarpa Engl. & Diels Leaf Essential Oil from Côte d'Ivoire

Chemistry and pharmacology of three antiplasmodial traditional medicinal plants from tropical Africa – A review

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