Boswellic acids as natural anticancer medicine: Precious gift to humankind

Sharma, Tarun; Jana, Snehasis

doi:10.1016/j.hermed.2019.100313

Cited by 14 publications

(6 citation statements)

References 83 publications

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“…This is consistent with the notion that β -boswellic acid impairs the morphology of the ER and/or the expression of ER-resident proteins in a different manner from ursolic acid or asiatic acid. Boswellic acid and its analogues have been shown to inhibit many molecular targets, such as transcription factors, protein kinases, receptors, and enzymes, for its anti-inflammatory and anticancer activities [ 31 , 32 , 33 ]. Nevertheless, the molecular targets of β -boswellic acid for glycoprotein transport and N -glycosylation remain unclear.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: β-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells

2022

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Ursane-type pentacyclic triterpenoids exert various biological effects, including anticancer and anti-inflammatory activities. We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1α. However, the structure–activity relationship of ursane-type pentacyclic triterpenoids remains unclear. In the present study, the biological activities of seven ursane-type pentacyclic triterpenoids (β-boswellic acid, uvaol, madecassic acid, 3-O-acetyl-11-keto-β-boswellic acid, ursolic acid, corosolic acid, and asiatic acid) were investigated. We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and α-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group. We also showed that β-boswellic acid interfered with ICAM-1 glycosylation in a different manner from other ursane-type pentacyclic triterpenoids.

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Section: Resultsmentioning

confidence: 99%

Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: β-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells

2022

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“…Urs-12-en-24-oic acid, 3-oxo-, methyl ester is categorized into boswellic acids used widely as anti-inflammatory agents, including as an anti-cancer treatment. Additionally, the boswellic acids have potent anti-cancer efficacy against diverse malignant cancers [ 49 , 50 ]. The KEGG pathway enrichment analysis of 24 targets suggested that a total of 20 signaling pathways were involved in cancer occurrence and development.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology-Based Study to Uncover Potential Pharmacological Mechanisms of Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.) Flower against Cancer

Adnan

Cho

2021

Molecules

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Cirsium japonicum var. maackii (Maxim.) Matsum. or Korean thistle flower is a herbal plant used to treat tumors in Korean folk remedies, but its essential bioactives and pharmacological mechanisms against cancer have remained unexplored. This study identified the main compounds(s) and mechanism(s) of the C. maackii flower against cancer via network pharmacology. The bioactives from the C. maackii flower were revealed by gas chromatography-mass spectrum (GC-MS), and SwissADME evaluated their physicochemical properties. Next, target(s) associated with the obtained bioactives or cancer-related targets were retrieved by public databases, and the Venn diagram selected the overlapping targets. The networks between overlapping targets and bioactives were visualized, constructed, and analyzed by RPackage. Finally, we implemented a molecular docking test (MDT) to explore key target(s) and compound(s) on AutoDockVina and LigPlot+. GC-MS detected a total of 34 bioactives and all were accepted by Lipinski’s rules and therefore classified as drug-like compounds (DLCs). A total of 597 bioactive-related targets and 4245 cancer-related targets were identified from public databases. The final 51 overlapping targets were selected between the bioactive targets network and cancer-related targets. With Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, a total of 20 signaling pathways were manifested, and a hub signaling pathway (PI3K-Akt signaling pathway), a key target (Akt1), and a key compound (Urs-12-en-24-oic acid, 3-oxo, methyl ester) were selected among the 20 signaling pathways via MDT. Overall, Urs-12-en-24-oic acid, 3-oxo, methyl ester from the C. maackii flower has potent anti-cancer efficacy by inactivating Akt1 on the PI3K-Akt signaling pathway.

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“…Acetyl-11-keto-β-Boswellic acid has been observed to inhibit the cell growth by the inhibition of Ki-67, CD31, Cycloxygenase-2, MMP-9, CXCR4, and VEGF in cancerous cells of pancreas 48 . The major analogues of β-Boswellic acid, such as 3-O-acetylβ-Boswellic acid and 11-keto-β-Boswellic acid have been found to have an anti-tumour activity in leukaemia in which there is inhibition of DNA, RNA and protein synthesis in the human leukemia-60 cells.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

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2021

IJPSR

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Boswellic acids as natural anticancer medicine: Precious gift to humankind

Cited by 14 publications

References 83 publications

Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: β-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells

Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: β-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells

Network Pharmacology-Based Study to Uncover Potential Pharmacological Mechanisms of Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.) Flower against Cancer

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