Boswellic acid attenuates asthma phenotype by downregulation of GATA3 via nhibition of PSTAT6

Zhou, Xiao Qin; Jg, Cai; Ww, Zhu; Hy, Zhao; Wang, K; Xf, Zhang

doi:10.4238/2015.july.3.22

Cited by 11 publications

(6 citation statements)

References 21 publications

(27 reference statements)

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“…Significant reduction in Th2 cytokines, suppressed airway inflammatory cells infiltration induced by allergens, resulting in reduced eosinophil and total inflammatory cells in BALF has been recorded in various studies of Boswellic acid testing. These results supported that Boswellic acid appears to be effective for the treatment of allergic asthma and can be developed as an anti-asthmatic agent 74,75 .…”

Section: Anti-diabetic Activitysupporting

confidence: 58%

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2021

IJPSR

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Section: Anti-diabetic Activitysupporting

confidence: 58%

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2021

IJPSR

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“…More novel drugs with high efficiency and low toxicity still need to be discovered [ 10 , 11 ]. 3-O-acetyl-11-keto-β-boswellic acid (AKBA), isolated from the gum resin of Boswellia serrata and Boswellia carteri Birdw., is widely used in Africa, India, and China [ 12 ] to treat inflammatory diseases including arthritis [ 13 ], colitis [ 14 ], Crohn’s disease [ 15 ] and asthma [ 16 , 17 ], as well as some other illnesses [ 18 , 19 ]. Boswellic acid exerts its anti-inflammatory therapeutic effects by directly interacting with IκB kinases [ 20 ] and inhibiting nuclear factor-κB-regulated gene expression [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase

Wan

Liu

et al. 2018

J Exp Clin Cancer Res

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BackgroundGlioblastoma (GBM) is the most common, malignant, and lethal primary brain tumor in adults accounting for about 50% of all gliomas. Up to now, the chemotherapy approaches for GBM were limited. 3-O-acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., was reported to inhibit the growth of many types of cancer cells; however, the underlying mechanism of its anticancer effects are still unclear.MethodsThe effects of AKBA on cell viability and its cytotoxicity were determined using CCK8 and LDH kits respectively. The EdU-DNA synthesis assay was used to evaluate inhibition of cell proliferation by AKBA. The role of AKBA in glioblastoma cell functions such as migration/invasion, and colony formation was evaluated using transwell chambers and soft agar, respectively. Flow cytometry and western blotting were used to detect AKBA-induced apoptosis. Potential mechanisms of AKBA action were explored by RNA sequencing and the identified hub genes were validated by real-time quantitative PCR and western blotting. Finally, the in vivo anti-tumor activity of AKBA was evaluated against a human glioblastoma cell line, U87-MG, in a xenograft mouse model.ResultsAKBA inhibited cell proliferation, caused the release of LDH, decreased DNA synthesis, and inhibited the migration, invasion, and colony formation of U251 and U87-MG human glioblastoma cell lines. AKBA increased apoptosis as well as the activity of caspase 3/7 and the protein expression of cleaved-caspase 3 and cleaved PARP, while decreasing mitochondrial membrane potential. RNA-sequencing analyses showed that AKBA suppressed the expression of pRB, FOXM1, Aurora A, PLK1, CDC25C, p-CDK1, cyclinB1, Aurora B, and TOP2A while increasing the expression of p21 and GADD45A. These findings were validated by qRT-PCR and western blotting. The data are consistent with a mechanism in which AKBA arrested the cell cycle in glioblastoma cells at the G2/M phase by regulating the p21/FOXM1/cyclin B1 pathway, inhibited mitosis by downregulating the Aurora B/TOP2A pathway, and induced mitochondrial-dependent apoptosis. Oral administration of AKBA (100 mg/kg) significantly suppressed the tumorigenicity of U87-MG cells in a xenograft mouse model.ConclusionsTaken together, these results suggest that AKBA (molecular weight, 512.7 Da) might be a promising chemotherapy drug in the treatment of GBM.Electronic supplementary materialThe online version of this article (10.1186/s13046-018-0805-4) contains supplementary material, which is available to authorized users.

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“…It reduces the need for inhalation therapy with corticosteroids and long-acting beta-agonists (Ferrara et al 2015 ). Moreover, Liu et al ( 2015 ) and Zhou et al ( 2015 ) demonstrated that boswellic acid attenuates asthma phenotypes by downregulation of GATA3 via pSTAT6 inhibition. These results suggest that B. serrata might be effective in controlling the inflammation process in asthmatic conditions by inhibiting the production of pro-inflammatory mediators (Rashan et al 2019 ).…”

Section: Potential Therapeutic Effects Of Boswellic Acids/ B Serrata Extract Against Sars-cov-2-induced Pulmonary Lesimentioning

confidence: 99%

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

et al. 2021

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The most severe cases of COVID-19, and the highest rates of death, are among the elderly. There is an urgent need to search for an agent to treat the disease and control its progression. Boswellia serrata is traditionally used to treat chronic inflammatory diseases of the lung. This review aims to highlight currently published research that has shown evidence of potential therapeutic effects of boswellic acids (BA) and B. serrata extract against COVID-19 and associated conditions. We reviewed the published information up to March 2021. Studies were collected through a search of online electronic databases (academic libraries such as PubMed, Scopus, Web of Science, and Egyptian Knowledge Bank). Several recent studies reported that BAs and B. serrata extract are safe agents and have multiple beneficial activities in treating similar symptoms experienced by patients with COVID-19. Because of the low oral bioavailability and improvement of buccal/oral cavity hygiene, traditional use by chewing B. serrata gum may be more beneficial than oral use. It is the cheapest option for a lot of poorer people. The promising effect of B. serrata and BA can be attributed to its antioxidant, anti-inflammatory, immunomodulatory, cardioprotective, anti-platelet aggregation, antibacterial, antifungal, and broad antiviral activity. B. serrata and BA act by multiple mechanisms. The most common mechanism may be through direct interaction with IκB kinases and inhibiting nuclear factor-κB-regulated gene expression. However, the most recent mechanism proposed that BA not only inhibited the formation of classical 5-lipoxygenase products but also produced anti-inflammatory LOX-isoform-selective modulators. In conclusion a small to moderate dose B. serrata extract may be useful in the enhancing adaptive immune response in mild to moderate symptoms of COVID-19. However, large doses of BA may be beneficial in suppressing uncontrolled activation of the innate immune response. More clinical results are required to determine with certainty whether there is sufficient evidence of the benefits against COVID-19.

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Boswellic acid attenuates asthma phenotype by downregulation of GATA3 via nhibition of PSTAT6

Cited by 11 publications

References 21 publications

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3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

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