Bortezomib Eliminates Persistent Chlamydia trachomatis Infection through Rapid and Specific Host Cell Apoptosis

Itoh, Roichi; Kurihara, Yusuke; Yoshimura, Michinobu; Hiromatsu, Kenji

doi:10.3390/ijms23137434

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Drug repurposing, which has been researched mostly in cancer treatment, has also been tried in this regard. Itoh et al have shown that Bortezomib, an anticancer drug, may also be effective in treating CT infection through the induction of apoptosis [100]. More comprehensive studies are needed to be able to apply all these new strategies in the treatment of CT infection and to put the results of research into clinical practice.…”

Section: Treatment Failure and Novel Approachesmentioning

confidence: 99%

Chlamydia: The Female Reproductive System and Infertility

Özlem Özdemir-Karabağ

2023

Infectious Diseases

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Chlamydial infection can cause diseases in many organs, including the genitourinary system. It is the most reported sexually transmitted bacterial infection throughout the world and one of the leading cause of female infertility. Chlamydia affects columnar epithelium, so adolescent women are particularly at risk since the squamocolumnar junction is located on the ectocervix until early adulthood. The bacterium is usually transmitted through sexual activity. Genital tract infection is the most common clinical picture but 50% of infected men and 80% of infected women are asymptomatic. This is the most important reason for the infection’s being unrecognized and untreated. The most significant morbidity related to infection is partial or total sterility due to obstruction and scarring of the fallopian tubes. Chlamydia trachomatis infection, even if it does not present clinical symptoms, has been shown to be associated with increased tubal factor infertility, implantation failure, and disruption of embryo development.

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Section: Treatment Failure and Novel Approachesmentioning

confidence: 99%

Chlamydia: The Female Reproductive System and Infertility

Özlem Özdemir-Karabağ

2023

Infectious Diseases

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“…As for NG infections, the new window of opportunity for treating CT infections includes new drug development, specifically non-antibiotic therapy, or the drug repurposing strategy as an alternative, to "save time" [98]. Recently, some authors have published interesting findings suggesting the use of 4EpDN cyclic peptomer as a prophylactic CT treatment [99].…”

Section: Challenges and Opportunities Of The Current Therapeutic Weaponsmentioning

confidence: 99%

Chlamydial and Gonococcal Genital Infections: A Narrative Review

Rodrigues

Vieira‐Baptista

Catalão

et al. 2023

JPM

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Sexually transmitted infections (STIs) constitute one of the leading causes of disease burden worldwide, leading to considerable morbidity, mortality, health expenditures, and stigma. Of note are the most common bacterial STIs, chlamydial and gonococcal infections, whose etiological agents are Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively. Despite being usually asymptomatic, in some cases these infections can be associated with long-term severe complications, such as pelvic inflammatory disease, chronic pelvic pain, infertility, ectopic pregnancy, and increased risk of other STIs acquisition. As the symptoms, when present, are usually similar in both infections, and in most of the cases these infections co-occur, the dual-test strategy, searching for both pathogens, should be preferred. In line with this, herein we focus on the main aspects of CT and NG infections, the clinical symptoms as well as the appropriate state-of-the-art diagnostic tests and treatment. Cost-effective strategies for controlling CT and NG infections worldwide are addressed. The treatment for both infections is based on antibiotics. However, the continuing global rise in the incidence of these infections, concomitantly with the increased risk of antibiotics resistance, leads to difficulties in their control, particularly in the case of NG infections. We also discuss the potential mechanism of tumorigenesis related to CT infections. The molecular bases of CT and NG infections are addressed, as they should provide clues for control or eradication, through the development of new drugs and/or effective vaccines against these pathogens.

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Section: Treatment Failure and Novel Approachesmentioning

confidence: 99%

“…Interestingly, drug repurposing, a strategy commonly investigated for cancer treatment, has also been explored in this field [ 99 , 100 ]. Specifically, Itoh et al have reported the potential role of bortezomib, an anticancer drug, to treat Ct infections by apoptosis induction [ 100 ]. Notwithstanding all these new strategies for treating Ct infection, further comprehensive studies are needed in order to improve the translation of these research results into clinical practice.…”

Section: Treatment Failure and Novel Approachesmentioning

confidence: 99%

Therapeutic Options for Chlamydia trachomatis Infection: Present and Future

et al. 2022

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Sexually transmitted infections (STIs), such as Chlamydia trachomatis (Ct) infection, have serious consequences for sexual and reproductive health worldwide. Ct is one of the most common sexually transmitted bacterial infections in the world, with approximately 129 million new cases per year. C. trachomatis is an obligate intracellular Gram-negative bacterium. The infection is usually asymptomatic, notwithstanding, it could also be associated with severe sequels and complications, such as chronic pain, infertility, and gynecologic cancers, and thus there is an urgent need to adequately treat these cases in a timely manner. Consequently, beyond its individual effects, the infection also impacts the economy of the countries where it is prevalent, generating a need to consider the hypothesis of implementing Chlamydia Screening Programs, a decision that, although it is expensive to execute, is a necessary investment that unequivocally will bring financial and social long-term advantages worldwide. To detect Ct infection, there are different methodologies available. Nucleic acid amplification tests, with their high sensitivity and specificity, are currently the first-line tests for the detection of Ct. When replaced by other detection methods, there are more false negative tests, leading to underreported cases and a subsequent underestimation of Ct infection’s prevalence. Ct treatment is based on antibiotic prescription, which is highly associated with drug resistance. Therefore, currently, there have been efforts in line with the development of alternative strategies to effectively treat this infection, using a drug repurposing method, as well as a natural treatment approach. In addition, researchers have also made some progress in the Ct vaccine development over the years, despite the fact that it also necessitates more studies in order to finally establish a vaccination plan. In this review, we have focused on the therapeutic options for treating Ct infection, expert recommendations, and major difficulties, while also exploring the possible avenues through which to face this issue, with novel approaches beyond those proposed by the guidelines of Health Organizations.

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Bortezomib Eliminates Persistent Chlamydia trachomatis Infection through Rapid and Specific Host Cell Apoptosis

Cited by 3 publications

References 29 publications

Chlamydia: The Female Reproductive System and Infertility

Chlamydia: The Female Reproductive System and Infertility

Chlamydial and Gonococcal Genital Infections: A Narrative Review

Therapeutic Options for Chlamydia trachomatis Infection: Present and Future

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