Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities

Conserva, Lúcia M.; Ferreira, Jesu Costa

doi:10.4103/0973-7847.95866

Cited by 57 publications

(31 citation statements)

References 50 publications

(67 reference statements)

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“…Statistics indicate that men are largely plagued by lung, colon, rectal and prostate cancer, while women increasingly suffer from breast, colon, rectal, and stomach cancer [24]. The literature indicates that many natural products are available as chemo protective agents against commonly occurring cancer types [25]. Species of Rubiaceae as well as their isolated compounds possess diverse biological activities, including anti-inflammatory, antitumor, antimicrobial, larvicidal, antioxidant, gastrointestinal, anti-ulcer, and hepato protective, with alkaloids and iridoids as the major active principles.…”

Section: Resultsmentioning

confidence: 99%

Isolation of Urosilic Acid from Knoxia corymbosa

R¹,

Ramakrishna²,

K³

et al. 2017

Nat Prod Chem Res

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Air-dried, milled leaves of Knoxia corymbosa (220 gm) were extracted repeatedly with dichloromethane. After removal of solvent in vacuo, the CH 2 Cl 2 -solvent residue was fractionated by using hexane and ethyl acetate solvents. After fractionation, all fractions are submitted for NMR spectroscopy. Out of all fractions interesting fractions are subjected to column chromatography, so that we isolated one pure compound as Ursolic acid which is a known compound as it is characterized by using reference data. This is the first time to be isolated the above compound from this species. Ursolic acid is a five-membered cyclic triterpenoid compound. A structure of the isolated compound has been assigned on the basis of their analytical data. By surveying the literature, we came to understand that the compound ursolic acid is a cyclic five-member triterpenoid first to be isolated from Knoxia corymbosa. And also, it is first time to isolate the above compound from this species Knoxia corymbosa.

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Section: Resultsmentioning

confidence: 99%

Isolation of Urosilic Acid from Knoxia corymbosa

R¹,

Ramakrishna²,

K³

et al. 2017

Nat Prod Chem Res

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“…39 The crude extract tested negative to alkaloids.This finding is contrary to report of Conserva and Ferreira et al in 2012 that alkaloids were present in species of Borreria. 40 Previous studies indicated that many phenolic and steroidal compounds possessed anti-plasmodial activities. [41][42][43] Malarial pathogenesis was reported to be associated with free radicals formation and decrease of antioxidant level.…”

Section: Discussionmentioning

confidence: 99%

“…19 Borreria ocymoides (Burm F) DC is a weak, erect and decumbent herb and belongs to the family Rubiaceae. 20 The plant has several folkloric and ethno medicinal uses which include dermatological use in treatment of ring worm and eczema in Nigeria, antihelmintic treatment of internal worms, treatment of microbial infections (dysentery, diarrhoea, gonorrhea), aids healing of wounds, 21 gastric ulcer protective potency 22.…”

Section: Introductionmentioning

confidence: 99%

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Adesegun¹,

Orabueze²,

Coker³

2017

Phcog J

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Introduction: Borreria ocymoides (Burm F) DC is a weak, erect and decumbent herb that has several folkloric, ethno medicinal uses and is included in antimalarial preparations by some traditional healers. It is also used in treatment of ring worm, eczema and microbial infections. Objectives: To evaluate antimalarial activity of extract and fractions of Borreria ocymoides in Plasmodium berghei infected mice and to investigate their antioxidant activity using 1, 1-diphenyl-2-picryl-hydrazile (DPPH). Methods: The methanol extract of aerial part of B. ocymoides and the solvent fractions obtained from partition between organic solvents were assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei NK65 infected mice using the suppressive and curative test procedures. Chloroquine (10 mg/ml) was used as positive control. The antioxidant activity was evaluated using DPPH radical scavenging ability and determination of total phenolic content. Results: The crude extract (250 and 500 mg kg-1) produced a dose dependent anti-plasmodial activity in the suppressive and curative tests. The chemo suppression activity was best in the ethyl acetate fraction (87.31%) and in the order ethyl acetate >dichloromethane > hexane > aqueous fraction. The DPPH radical scavenging activity of the extract increased with concentration. The antioxidant activity was less than ascorbic acid used as positive control. Oral administration up to 5 g/kg produced no noticeable deleterious effect 24 hours after dosing and up to 7 days afterwards. Conclusion:The results indicated that the extract has a potent anti-plasmodial activity against Plasmodium berghei and the activity seems to reside in the mid-polar fractions. Thus, the plant is a potential source of new antimalarial agents.

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“…To the best of my knowledge, this study is the first record of AGI testing of (Conserva and Ferreira 2012;Hernandez 2007). Previous studies addressed their antimicrobial activity and their chemical composition and found that both plants produced essential oils comprised mainly of mono-and sesquiterpenes (Conserva and Ferreira 2012;Hernandez 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies addressed their antimicrobial activity and their chemical composition and found that both plants produced essential oils comprised mainly of mono-and sesquiterpenes (Conserva and Ferreira 2012;Hernandez 2007).…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

Bullard-Roberts¹

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Thanks to my Ethnobotany sisters, Cassy Quave and Janna Rose, for making the path smoother and to the Koptur lab for adopting me when I had no lab family left.Thanks to Sasha, Asha and Xtina from the Jaffe and Berry Labs at BBC for sharing their space, equipment and expertise.Thanks to James and Kate at the Quave Lab at Emory University for helping me to navigate through failed trials and strange calculations. Diabetes mellitus (DM) is a group of non-infectious diseases that cause hyperglycemia. DM symptoms were first clinically described by ancient Greek physicians whose prescriptions included plant-based remedies. Today, DM affects >400 million people globally and prevalence rates are rapidly increasing in developing countries where basic healthcare relies on local knowledge of botanical remedies. Many developing countries are home to diverse peoples and plants-providing fodder for varied plant-selection strategies and unique botanical pharmacopoeias.I addressed the plant-selection strategies used in a multi-ethnic, developing country, Trinidad and Tobago (T&T), to ascertain their role in shaping the local antidiabetic pharmacopoeia and to assess their benefits and risks in identifying safe and useful remedies. Using literature reviews, field surveys, and laboratory bioassays, Icompleted three categories of analysis.Ethnobotanical analyses showed that T&T's antidiabetic pharmacopoeia is primarily of recent origin as >50% of the 48 historical DM remedies were Neotropical natives, including congenerics of well-known medicinal Paleotropical genera. ix Nevertheless, conservative knowledge transmission was also evident as several Paleotropical species of T&T's pharmacopoeia, including Momordica charantia and Catharanthus roseus were also used in Africa, India and across the Caribbean.Paleotropical natives with a long history of use are likely to be safer remedies.Ethno-medicinal analyses of the pre-and post-2000 DM remedies of T&T, totaling 99 species, suggest that the centuries-old hot/cold folk disease-model was the model predominantly used in plant-selection. Parallels found between T&T folk concepts and biomedical mechanisms of DM provide probable bases for efficacy but the chronic use of purgatives and bitter-tasting plants is likely to be risky.Phytochemical analyses revealed that 69% of the tested plant extracts contained phenolic compounds, with more than half producing >80% alpha-glucosidase inhibition.Phenolic content and alpha-glucosidase inhibition were strongly correlated among food plants used as medicines, suggesting higher probability of selection as a result of nontarget effects. The medicinal use of food plants may provide the best margins of safety and efficacy in identifying antidiabetic remedies.Together, these analyses showed how culture-specific plant-selection strategies can identify safe, useful remedies for developing countries to address their increasing DM prevalence in a cost-effective and sustainable manner.x Table 3 Regions of the Indian sub-continent from which indentured laborers...

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Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities

Cited by 57 publications

References 50 publications

Isolation of Urosilic Acid from Knoxia corymbosa

Isolation of Urosilic Acid from Knoxia corymbosa

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

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