Borreliae, Human Relapsing Fever, and Parasite-Vector-Host Relationships

Felsenfeld, Oscar

doi:10.1128/mmbr.29.1.46-74.1965

Cited by 52 publications

(21 citation statements)

References 37 publications

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“…Borreliacidal activity of human immune sera has been described both in relapsing fever infection [18] and in Lyme disease [4]. Human immunoglobulin G against B. burgdorferi kill the spirochaete by activating the classical complement pathway [19], and epitopes located on the 34 kDa OspB of B. burgdorferi IRS were shown to be responsible for mediating the lysis of borrelia cells in the presence of complement and specific mouse monoclonal antibodies [20].…”

Section: Discussionmentioning

confidence: 99%

Animal and human antibodies reactive with the outer surface protein A and B of Borrelia burgdorferi are borreliacidal, in vitro, in the presence of complement

Sambri

1993

FEMS Immunology and Medical Microbiology

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Polyspecific antibodies present in ascitic fluids of mice (pMIAFs) immunized with whole Borrelia burgdorferi cells exerted borreliacidal activity in vitro when tested with complement and homologous antigen but not with heterologous B. hermsii. Similarly, monospecific mouse antibodies obtained by immunizing mice with purified preparations of outer surface protein A and B of B. burgdorferi were borreliacidal. On the contrary, mouse monospecific antibodies raised against the 41-kDa flagellar protein of B. burgdorferi did not kill borreliae in the presence of complement. A complement-mediated, in vitro, borreliacidal activity was observed in human sera from patients with Lyme disease when antibodies against OspA and/or OspB were detectable in sera by the Western blotting technique. The in vitro borreliacidal activity of human sera was evident after 14 h incubation with live B. burgdorferi spirochaetes and complement, whereas antibodies present in mouse immune ascitic fluids killed borreliae after 1 h incubation.

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Section: Discussionmentioning

confidence: 99%

Animal and human antibodies reactive with the outer surface protein A and B of Borrelia burgdorferi are borreliacidal, in vitro, in the presence of complement

Sambri

1993

FEMS Immunology and Medical Microbiology

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“…Many workers (see Fetsenfeld, L9651 have felt that the mysterious reappearances of the disease indicated either an animal : ?servoir or a transformation of the tick-borne spirochaete, which is ubiquitous in Africa, into the louse-borne (Nicolle andAnderson, 1927: Boiron, 1948). No naturally occurring animal infection of Borrelia recurrentis has ever been found, though many of the tick-borne strains have animal reservoirs (see Felsenfeld, 1965).…”

Section: The Endemic Focusmentioning

confidence: 99%

“…Jolinstone (1942) has discussed the taxonomic problems. Most authorities accept the nomenclature given by Felsenfeld (1965) whose review of the literature is exhaustive; in this the louse-borne spirochaete is known as B. recurr"nti.s and the tick-borne spirochaetes are named according to their tick vector.…”

Section: The Or(anism and Its Vectormentioning

confidence: 99%

“…Seydian, Mofidi, and Bahmanyar, 1949) who have used sensitive techniques (see. Schuhardt, 1942;Felsenfeld, 1965) have found that each antigenic variant, strain, or type retains its identity on passage for at least one year but loses it on relapse and is linable to reinfect the same animal. Such specific variation, which haq lbeen obqerved also in human epidemics (Toyota, 1919) probably aecounts fur reinfection after spontaneous cure.…”

Section: The Or(anism and Its Vectormentioning

confidence: 99%

See 1 more Smart Citation

LOUSE-BORNE RELAPSING FEVER<subtitle>A Clinical and Laboratory Study of 62 Cases in Ethiopia and a Reconsideration of the Literature<sup>1</sup></subtitle>

1970

QJM: An International Journal of Medicine

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“…The European hedgehog showed some promise; however, these studies were plagued by problems of unclear demarcation among species and lack of experimental reproducibility, through imprecise enumeration and differing routes of infection, not to mention the potential for differential virulence associated with different antigenic variants of these spirochaetes. Instead, the ‘one vector–one species’ concept became popular for grouping of aetiological agents of relapsing fever [2].…”

mentioning

confidence: 99%

Myths, legends and realities of relapsing fever borreliosis

Cutler

2009

Clinical Microbiology and Infection

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Relapsing fever borreliosis is often shrouded in mystery. From its discovery, it has evaded fulfilment of Koch's postulates. It has resulted in epidemic waves of infection, although it is now mostly localized to particular endemic pockets of infection. Structurally, this spirochaete breaks many paradigms for conventional microorganisms, e.g. through its segmented genomic structure. Disclosure of host-microbial interactions is revealing a plethora of mechanisms, from antigenic variation to binding of various host-derived proteins. We dispel some of the myths and explore current understanding of this much neglected area through a series of reviews within this theme section.

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Borreliae, Human Relapsing Fever, and Parasite-Vector-Host Relationships

Cited by 52 publications

References 37 publications

Animal and human antibodies reactive with the outer surface protein A and B of Borrelia burgdorferi are borreliacidal, in vitro, in the presence of complement

Animal and human antibodies reactive with the outer surface protein A and B of Borrelia burgdorferi are borreliacidal, in vitro, in the presence of complement

LOUSE-BORNE RELAPSING FEVER<subtitle>A Clinical and Laboratory Study of 62 Cases in Ethiopia and a Reconsideration of the Literature<sup>1</sup></subtitle>

Myths, legends and realities of relapsing fever borreliosis

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