Borrelia burgdorferi specific serum and cerebrospinal fluid antibodies in Lyme neuroborreliosis

Pietikäinen, Annukka; Glader, Otto; Kortela, Elisa; Kanerva, Mari; Oksi, Jarmo; Hytönen, Jukka

doi:10.1016/j.diagmicrobio.2022.115782

Cited by 1 publication

(4 citation statements)

References 17 publications

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“…Remarkably, p18—an antigen linked to severe neuroborreliosis [ 30 ]—was present in six cases. The antigens p100, OspC, and VlsE—linked to neuroborreliosis [ 31 , 32 , 33 , 34 , 35 ]—were respectively observed in three, three and two cases. Overall, 7 patients out of 10 had 1 or several neuroborelliosis-linked antigens among p18, p100, OspC, and VlsE.…”

Section: Resultsmentioning

confidence: 99%

“…In more precise biological terms, complete regression was obtained in seven patients out of nine who had positive Borrelia ELISA (77.7%). Out of the seven patients with the documented neuroborreliosis-linked antigens p18, p100, OspC, and VlsE [ 30 , 31 , 32 , 33 , 34 , 35 ], i.e., patients with molecular indicators of highly probable neuroborreliosis, five were cured (71.4%).…”

Section: Discussionmentioning

confidence: 99%

“…Yet, importantly, seven patients out of nine had neuroborreliosis-linked specific antigens p18, p100, OspC, and VlsE [ 30 , 31 , 32 , 33 , 34 , 35 ]. Six out of nine had p18, an antigen linked to severe neuroborreliosis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, particular qualitative attention was paid to the presence of antigens that have been found to correlate with neuroborreliosis: p18 [ 30 , 31 ]; p100, OspC [ 31 , 32 , 33 ]; and VlsE [ 32 , 33 , 34 ], a fact recently confirmed [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

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Complete Remission in Paralytic Late Tick-Borne Neurological Disease Comprising Mixed Involvement of Borrelia, Babesia, Anaplasma, and Bartonella: Use of Long-Term Treatments with Antibiotics and Antiparasitics in a Series of 10 Cases

Trouillas¹,

Franck²

2023

Antibiotics

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This study aimed to demonstrate that severe neurological motor deficits in the context of late tick-borne disease with mixed microorganism involvement are eligible for long-term combined antibiotic/antiparasitic treatments. The inclusion criteria were: 1. neurological limb paralysis with a disability score >4 according to the EDSS Kurtzke disability scale; 2. serological tests pointing to an involvement of the main tick-borne microorganisms Borrelia burgdorferi s.l., Babesia, Anaplasma, and Bartonella; 3. a general disease for more than 6 months with fatigue, pain and subjective cognitive deficit. The patients were administered long-term treatments with repeated cycles (at least three) of 35-day IV ceftriaxone and repeated oral regimens of azithromycin–doxycycline and azithromycin–doxycycline–rifampicin. For Babesia, repeated courses of atovaquone–azithromycin were administered. Ten patients had intractable or severe motor deficits before treatment in the context of Borrelia (two cases) Borrelia–Babesia (four cases), Borrelia–Babesia–Anaplasma (two cases), Borrelia–Babesia–Anaplasma–Bartonella (one case) and Babesia–Anaplasma (one case). For several months, five had been in wheelchairs, and four had been walking with sticks. Seven patients out of 10 (70%) showed complete remission after a mean active treatment duration of 20.1 + 6.6 months, with a mean number of 4 ceftriaxone cycles. Three patients showed an initial remission but suffered secondary antibiotic/antiparasitic-resistant motor recurrences. Among the nine patients with Borrelia serologic positivity, treatments obtained complete remission in seven cases (77%). The findings of this ten-case series suggest the usefulness of long-term antibiotic/antiparasitic treatments in patients with severe late tick-borne neurological deficits with highly significant elements of tick-borne involvement.

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