Borrelia burgdorferi and Localized Scleroderma

Lecerf, V.; Bagot, Martine; Revuz, J; Touraine, R; Dournon, E

doi:10.1001/archderm.1989.01670140149031

Cited by 21 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…suggested that positive serological findings in these patients with morphoea are probably not causally linked to the pathogenesis of morphoea, but are a sign of high population prevalence of antibodies against B. burgdorferi . 2 The prevalence of borreliosis‐specific antibodies in clinically asymptomatic persons was as high as 13·7% in Bavarian forest workers, 27 and has been found in several reports to be 2–3% in healthy blood donors in Germany 28,29 …”

Section: Discussionmentioning

confidence: 95%

“… 1 In the following years, serological, immunohistochemical and culture approaches were performed to determine the role of Borrelia burgdorferi in the pathogenesis of morphoea. 2–5 However, conflicting results were obtained. Since 1993, several authors have used the polymerase chain reaction (PCR) to detect B. burgdorferi in lesional skin of patients with morphoea, but the relationship between morphoea and this organism has remained controversial.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction

Weide¹,

Schittek²,

Klyscz³

et al. 2000

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction

Weide¹,

Schittek²,

Klyscz³

et al. 2000

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…However, antibodies against B. burgdorferi were found in 2–11% of asymptomatic patients depending on the geographical region. 61 In Europe and Asia, DNA from B. burgdorferi was detected by PCR in lesional skin in 0–100% (17 of 82) of patients with morphoea. In the U.S.A. none of 98 patients was reported to be positive.…”

Section: Discussionmentioning

confidence: 99%

“…In clinically asymptomatic patients, antibodies against B. burgdorferi were found in 2–11% of cases depending on the geographical region. 61 For that reason several authors presume that the positive serologies in patients with morphoea are not causally linked to the pathogenesis of morphoea, but are a sign of a high prevalence of antibodies against B. burgdorferi in the local population.…”

Section: Serological Findingsmentioning

confidence: 99%

Is morphoea caused by Borrelia burgdorferi? A review

Weide

Walz

Garbe

2000

British Journal of Dermatology

View full text Add to dashboard Cite

The aetiology of morphoea and lichen sclerosus et atrophicus is still unknown. Since the detection of Borrelia burgdorferi (B. burgdorferi) as the causative agent of Lyme disease, there has been debate about a possible association between B. burgdorferi and morphoea. Initial serological and cultural studies showed controversial results. The introduction of polymerase chain reaction (PCR) initially suggested an association between B. burgdorferi and morphoea. We reviewed the literature on B. burgdorferi (specific serology, immunohistology, culture, lymphocyte stimulation and DNA detection by PCR) since 1983, using Medline and Current Contents. Histological and immunohistological detection of B. burgdorferi was reported in 0-40% (20 of 82) of the cases with morphoea and in 46-50% (17 of 36) of the cases with lichen sclerosus et atrophicus. Cultivation of spirochetes from lesional skin succeeded in five patients (five of 68) with morphoea, but failed in patients with lichen sclerosus et atrophicus. In Europe and Asia, serological detection of antibodies against B. burgdorferi was described in 0-60% (138 of 609) of patients with morphoea and in 19% (six of 32) in the U.S.A. For lichen sclerosus et atrophicus 0-25% of the published cases (three of 23) in Europe and Asia were seropositive. DNA from B. burgdorferi was detected by PCR in 0-100% (17 of 82) of the tissues of patients with morphoea in Europe and Asia, but not a single case among 98 patients was reported to be positive from the U. S.A. In Europe and Asia, borrelial DNA was detected in 0-100% (nine of 28) of the cases with lichen sclerosus et atrophicus, whereas in the U.S.A. none of 48 patients was positive. There are two possible explanations for these contradictory findings: the most likely is that B. burgdorferi is not a causative agent for morphoea. Another possible explanation could be that a subset of morphoea is caused by a special subspecies of B. burgdorferi that is present in Europe and Asia but does not occur in the U.S.A.

show abstract

“…Cases have been reported of patients with localized seleroderma and ESA who have high antibody titres in serum and cerebrospinal fluid, as well as neurological symptoms [18,22]. Other researchers, however, have not eonfirmcd the positive results in serologieal testing [2,[40][41][42] and have attributed the positive results to geographical faetors, wherever the disease is endemic [42].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous borreliosis in Northern Greece

Lefaki

Kalogeropoulou

Stefanidou

et al. 1993

Acad Dermatol Venereol

View full text Add to dashboard Cite

Our study is the first international report on cutaneous Lyme disease in Greece. Our purpose was, firstly, to assess the advisability of carrying out specific serological testing in the case of skin conditions certainly or possibly related to Borrelia burgdorferi (Bb) and, secondly, to evaluate the necessity and efficacy of treatment. Our research was carried out between 1988 and 1991 on 68 patients suffering from cutaneous diseases generally related to Bb and 57 control subjects. Specific IgM and IgG antibodies were detected by indirect immunofluorescence assay (IFA) and titers > 1/256 were considered as positive. All 57 control subjects were negative. Eighteen out of the 68 patients (26.5%) were positive. Eive out of the eight patients (62.5%) with cutaneous diseases certainly related to Bb, and 13 out of the 60 patients (21.6%) with skin diseases possibly related to Bb, were positive. The high percentage (26.5%) in skin diseases generally related to Bb suggests that patients with all these diseases should be tested by IFA. Negative results in control patients confirm the specificity of IFA and indicate that it is unnecessary to perform this investigation in the absence of specific clinical manifestations. Even though we regard scleroderma to be a late form of cutaneous borreliosis, it shows a favorable response to therapy, whereas granuloma annulare, even after titer elimination, remains clinically unchanged. Treatment should be administered not only to patients with high titers, but must be regarded as essential in all seropositive cases with dermatoses generally related to borreliosis, in view of the possibility of a late manifestation of the disease.

show abstract

Borrelia burgdorferi and Localized Scleroderma

Cited by 21 publications

References 6 publications

Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction

Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction

Is morphoea caused by Borrelia burgdorferi? A review

Cutaneous borreliosis in Northern Greece

Contact Info

Product

Resources

About