Boronic acids—A novel class of bacterial mutagen

Current data regarding the structure-toxicity relationship of boron-containing compounds

“…Considering the doses employed, the results of several studies strongly suggest that these compounds do not produce toxic effects in humans (SorianoUrsúa, 2014a;Sanjoh, 2014;Fu, 2014). Moreover, it is known that they have a low mutagenic or cytotoxic effect (O'Donovan, 2011;Hansen, 2015;Pellizzaro, 2015;Scott, 2015). O'Donovan et al (2011) reported that a number of aryl boronic acids have low or null mutagenic effects.…”

“…Moreover, it is known that they have a low mutagenic or cytotoxic effect (O'Donovan, 2011;Hansen, 2015;Pellizzaro, 2015;Scott, 2015). O'Donovan et al (2011) reported that a number of aryl boronic acids have low or null mutagenic effects. Another report shows a more toxic mutagenic effect on prokaryotic than eukaryotic cells (Fig.…”

Experimental (FT-IR, FT-Raman, UV–Vis, 1H and 13CNMR) and computational (density functional theory) studies on 3-bromophenylboronic acid

“…O'Donovan et al [7] concluded a novel class of bacterial of boronic acids mutagen that may not act by direct covalent binding to DNA. Biomedical applications of boronic acid-containing polymers and biological of particular dichlorophenylboronic acids were studied [8][9][10].…”

Boronic Acids and Derivatives—Probing the Structure–Activity Relationships for Mutagenicity

“…The initial publication of positive Ames data by O'Donovan, et al showed that generally (one exception) the TA100 strain gave positive Ames activity, so the inclusion of TA100 in the 2-strain Ames testing shown in Tables 2 -5 may minimize the potential for a false negative in the testing reported here. 7 See the Supporting Information for details on the Ames activity by strain for the entries in Table 1, including one 5- strain entry in Table 5 (compound 49). For this small data set, two of the eleven compounds tested in the 5-strain Ames assay were positive in a strain other than TA98 or TA100.…”