Boron supplementation of peri-menopausal women affects boron metabolism and indices associated with macromineral metabolism, hormonal status and immune function

Nielsen, Forrest H.; Penland, James G.

doi:10.1002/(sici)1520-670x(1999)12:3<251::aid-jtra8>3.0.co;2-i

Cited by 60 publications

(35 citation statements)

References 15 publications

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“…Boron status also affects the populations of blood cells involved in the immune or inflammatory response. Perimenopausal women excreting an average of 1.1 and 3.0 mg boron/day during placebo and boron supplementation periods, respectively, had increased white blood cell numbers, an increased percentage of polymorphonuclear neutrophils, and a decreased percentage of lymphocytes during the boron supplementation period 43 …”

Section: Boron and The Inflammatory Or Immune Responsementioning

confidence: 99%

Is boron nutritionally relevant?

2008

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Evidence from numerous laboratories using a variety of experimental models, including humans, shows that boron is a bioactive beneficial element. Much evidence has come from studies that did not require nutritional or environmental stressors or fastidious methods in diet preparation or environmental control. The evidence includes deprivation studies showing that boron is necessary for some higher animals to complete the life cycle, and that realistic low boron intakes result in impaired bone health, brain function, and immune response. Thus, low boron intake is a relevant nutritional concern, which diets rich in fruits, vegetables, nuts, and pulses can prevent.

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Section: Boron and The Inflammatory Or Immune Responsementioning

confidence: 99%

Is boron nutritionally relevant?

2008

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“…Accumulating evidence has also suggested the importance of boron in human nutrition and metabolism, though the exact mechanism of action has not been well elucidated yet [18]. Boron plays important roles in brain development and function [19], hormone metabolism [20], regulation of inflammatory response [21], and bone and teeth growth [22]. Boron deficiency in diets has significantly reduced the growth of rat and pig bones [23].…”

Section: Introductionmentioning

confidence: 99%

Boron containing poly-(lactide-co-glycolide) (PLGA) scaffolds for bone tissue engineering

Doğan

Demirci

Bayır

et al. 2014

Materials Science and Engineering: C

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“…It is believed that optimum boron supplementation regulates catabolic enzymatic hydroxylation. Given these effects of boron, it is not surprising that it is beneficial for optimal calcium metabolism and in the prevention of bone loss [6] and, generally, in some disorders of unknown aetiology, such as osteoporosis, that exhibits disturbed major mineral metabolism [7,8] and an impact on osteo-arthritis by increasing the synthesis of corticosteroids [9,10]. Also, a recent study supports the hypothesis that boron has an important biological role that affects the mineral metabolisms of animals by influencing both biochemical and haematological mechanisms [11].…”

mentioning

confidence: 99%

Elevation of biosynthesis of endogenous 17‐B oestradiol by boron supplementation: One possible role of dietary boron consumption in humans

Naghii¹,

Mofid

2008

Journal of Nutritional & Environmental Medicine

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Background. Recent evidence indicates that boron has a widespread role in biochemistry and nutrition and may have anti-carcinogenic properties. It interacts with calcium, vitamin D and magnesium, which are all important in bone metabolism. Boron also increases steroid hormone concentrations in animals and humans and hints at a role in the prevention of chronic diseases such as osteoporosis, arthritis and other steroid hormone dependent diseases. It has been suggested that the interaction between boron and steroid hormone metabolism is mediated by the hydroxylation process that steroids need to be biologically active. Thus, the aim of this study was to investigate the effect of boron supplementation on the selected steroid hormone productions or steroidogenesis. Methods. The experimental design consisted of two trials, in two different occasions. Seven healthy male volunteers in one group and another nine healthy male volunteers in the second group consumed two tablets each containing 5 mg of boron per day and blood samples were collected prior to supplementation and after 4 and 8 weeks.Results. The mean total testosterone concentrations increased after supplementations. The mean plasma 17-B oestradiol concentrations increased significantly after 4 weeks (p50.009) and 8 weeks (p50.05) supplementations. The ratio of 17-B oestradiol to testosterone increased significantly (p50.01) after 4 weeks supplementation.Conclusions. It can be speculated that the elevation of endogenous oestrogen as a result of boron supplementation suggests a potential protective role for boron in preventing a number of clinical conditions or chronic diseases, with emphasis in animals or humans who are under stress conditions, which requires further studies and clarifications.

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Boron supplementation of peri-menopausal women affects boron metabolism and indices associated with macromineral metabolism, hormonal status and immune function

Cited by 60 publications

References 15 publications

Is boron nutritionally relevant?

Is boron nutritionally relevant?

Boron containing poly-(lactide-co-glycolide) (PLGA) scaffolds for bone tissue engineering

Elevation of biosynthesis of endogenous 17‐B oestradiol by boron supplementation: One possible role of dietary boron consumption in humans

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