Boron neutron capture therapy of cancer: Critical issues and future prospects

Yuan, Tai Ze; Xie, Shu Qing; Qian, Chao Nan

doi:10.1111/1759-7714.13232

Cited by 15 publications

(8 citation statements)

References 26 publications

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“…A third generation of boron-containing compounds were recently investigated. A stable boron cluster is attached to a tumor-targeting moiety via a hydrolytically stable linkage, such as low or high molecular weight agents [87]. Boron-containing amino acids, biochemical precursors, polyhedral boranes, DNA-binding agents, mannose, glucose, ribose, galactose, fucose, lactose molecules, amines, benzamides, nitroimidazole, nicotinamides, phosphates, phosphonates, isocyanates, azulenes, phenylureas, thioureas, and deualinium derivates are included in low molecular weight agents while high molecular weight agents include liposomes, receptor-targeting agents, and monoclonal antibodies.…”

Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

“…Boron-containing amino acids, biochemical precursors, polyhedral boranes, DNA-binding agents, mannose, glucose, ribose, galactose, fucose, lactose molecules, amines, benzamides, nitroimidazole, nicotinamides, phosphates, phosphonates, isocyanates, azulenes, phenylureas, thioureas, and deualinium derivates are included in low molecular weight agents while high molecular weight agents include liposomes, receptor-targeting agents, and monoclonal antibodies. These new generation boron-containing agents show better selective targeting properties when compared to the old generation boron compounds [87]. However, their biological properties depend on the density of the targeted sites and very little data have been reported to date on the third-generation of boron-containing agents.…”

Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

“…For the clinical application of BNCT, their findings provide reference about the secondary cancer risk, that requires further exploration. Hopefully, future research will identify new and better boron delivery agents for clinical use [87,141]. Randomized clinical trials help advance cancer therapy.…”

Section: Secondary Cancer Risk With Bnctmentioning

confidence: 99%

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Boron Chemistry for Medical Applications

2020

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Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.

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Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

Section: Development Of Novel Bnct Agentsmentioning

confidence: 99%

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Boron Chemistry for Medical Applications

2020

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“…49 HIF1α siRNA combined to anis amide-targeted lipid-calcium-phosphate NPs and combined PDT-PTT therapy is an emerging treatment approach for oral cancer that uses rose Bengal-conjugated graphene nanoribbons specific to oral cells. 50 Scientists have been targeting boron neutron-capture therapy with the use of nanocarriers for selectively building tumor-targeting compounds including boron and neutron irradiation. 51 Tongue carcinoma patients were benefitted from the association of ultrasound and bubble liposome that introduced plasmid into the tongue tissue.…”

Section: Nanotechnology-based Drug-delivery Systems In Oral Cancer Therapymentioning

confidence: 99%

Nanotechnology in Oral Cancer Prevention and Therapeutics: A Literature Review

Kumar

Jha

Barman³

2021

Indian J Med Paediatr Oncol

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The concept of nanotechnology revolves around the delivery of nano particle incorporated drugs which are originally engineered technology. Nanoparticles are used for targeted delivery and controlled release of a curative agents. Nanotechnology is gaining importance and is likely to be routine element of regular dental clinics. Nanomaterials are being incorporated in toothpastes, mouth rinses for improved efficiencies. It has found its use in restorative dental materials, anti-cariogenic enamel surface polishing agents, implant materials, etc. Few nanoparticles possess antimicrobial propertiesand intercepts bacterial activity. Nano dentistry is cost-effectiveness and timesaving compared to other techniques. Nano particles have also been beneficial to annihilate drug resistance, prevention of metastasis or lesion recurrence by earmarking malignant stem cells. Remarkable achievements were made in using nanoparticles for detecting and treating multiple variety of malignancies including colon cancer, prostate cancer, lung cancer, breast cancer, head and neck cancer, etc. This review was made to highlight the various clinical applications of nanotechnology in the diagnosis and curative care for oral cancer.

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“…The body weights and physical signs were also monitored simultaneously as indicators of systemic toxicity. 64,65 ■ ASSOCIATED CONTENT * sı Supporting Information…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Covalent Organic Polymer as a Carborane Carrier for Imaging-Facilitated Boron Neutron Capture Therapy

Shi

et al. 2020

ACS Appl. Mater. Interfaces

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Boron neutron capture therapy (BNCT) is an atomic targeted radiotherapy that shows fantastic suppression impact on locally intrusive threatening tumors. One key factor for effective BNCT is to aggregate an adequate concentration (>20 ppm) of 10 B in the cytoplasm of the tumor. Carborane-loaded polymer nanoparticles are promising because of their outstanding biocompatibility and plasma steadiness. In this study, a new class of carborane-loaded nanoscale covalent organic polymers (BCOPs) was prepared by a Schiff base condensation reaction, and their solubility was greatly improved in common solvents via alkyl chain engineering and size tailoring. The obtained BCOP-5T was further functionalized by biocompatible 1,2-distearoyl-snglycero-3-phosphoethanolamine-N-[amino(polyethylene-glycol)-2000] (DSPE-PEG, molecular weight 2000) to form stable aqueous-phase nanoparticles with a hydrodynamic diameter of around 100 nm. After chelating with radioactive copper-64, DSPE-BCOP-5T was tracked by positron emission tomography (PET) imaging and showed significant accumulation in the tumor. DSPE-BCOP-5T + neutron radiation showed remarkable tumor suppression in 4T1 tumor-bearing mice (murine breast cancer). No obvious physical tissue damage and abnormal behavior were observed, demonstrating that the boron delivery was successful and tumor-selective. To conclude, this study presents a theranostic COP-based platform with a well-defined composition, good biocompatibility, and satisfactory tumor accumulation, which is promising for PET imaging, drug delivery, and BNCT.

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Boron neutron capture therapy of cancer: Critical issues and future prospects

Cited by 15 publications

References 26 publications

Boron Chemistry for Medical Applications

Boron Chemistry for Medical Applications

Nanotechnology in Oral Cancer Prevention and Therapeutics: A Literature Review

Covalent Organic Polymer as a Carborane Carrier for Imaging-Facilitated Boron Neutron Capture Therapy

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