Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era

Suzuki, Minoru

doi:10.1007/s10147-019-01480-4

Cited by 199 publications

(175 citation statements)

References 48 publications

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“…Despite some promising results achieved by treating patients with recurrent head and neck cancer, high-grade gliomas and advanced melanomas, the development of novel boron delivery agents would lift this technology to the next level and support the implementation as advanced cancer treatment in clinics (Barth et al, 2018b ). Although linear accelerator-based neutron beams have been developed, allowing the generation of neutrons in hospitals, boron delivery agents with high boron loading and excellent selectivity are still needed (Suzuki, 2019 ).…”

Section: Boron Neutron Capture Therapymentioning

confidence: 99%

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

2020

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Cancer became recently the leading cause of death in industrialized countries. Even though standard treatments achieve significant effects in growth inhibition and tumor elimination, they cause severe side effects as most of the applied drugs exhibit only minor selectivity for the malignant tissue. Hence, specific addressing of tumor cells without affecting healthy tissue is currently a major desire in cancer therapy. Cell surface receptors, which bind peptides are frequently overexpressed on cancer cells and can therefore be considered as promising targets for selective tumor therapy. In this review, the benefits of peptides as tumor homing agents are presented and an overview of the most commonly addressed peptide receptors is given. A special focus was set on the bombesin receptor family and the neuropeptide Y receptor family. In the second part, the specific requirements of peptide-drug conjugates (PDC) and intelligent linker structures as an essential component of PDC are outlined. Furthermore, different drug cargos are presented including classical and recent toxic agents as well as radionuclides for diagnostic and therapeutic approaches. In the last part, boron neutron capture therapy as advanced targeted cancer therapy is introduced and past and recent developments are reviewed.

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Section: Boron Neutron Capture Therapymentioning

confidence: 99%

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

2020

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“…10 B atoms capture the thermal neutrons and instantly decay to produce an alpha particle ( 4 He), a recoiled lithium nucleus ( 7 Li), and low linear energy transfer (LET) γ radiation ( Figure 1). 10 B isotope atoms absorb low-energy thermal neutrons (< 0.5 eV), resulting in the reaction: 10 B + n → 7 Li + 4 He, wherein alpha particles acquire the high-LET, ≈150 keV/μm, 7 Li ion, ≈175 keV/μm [12]. A feature of these particles is that they provide a high energy along their very brief pathway (< 10 μm), which is comparable to the diameter of one cell.…”

Section: Physical Basesmentioning

confidence: 99%

Boron neutron capture therapy: Current status and future perspectives

Дымова

Taskaev

Richter

et al. 2020

Cancer Communications

178

173

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The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.

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“…44 Glioblastomların tedavisinde bor bileşiklerinin kullanılmasıyla birlikte Bor Nötron Yakalama Tedavisi [Boron Neutron Capture Therapy (BNCT)] ile bor bileşiklerinin sentezine odaklanan çalışmaların sayısı artmıştır. [45][46][47][48] Düşük molekül ağırlıklı bor içeren ilaçlar olan borfenilalanin ve sodyum borkaptat beyin tümörlerinin tedavisinde kullanılmaya başlamıştır. 46 BNCT metodu güncel olarak kanser tedavilerinde kullanılmaya başlanmıştır.…”

Section: Beyi̇n Tümörleri̇unclassified

Boron and Health

Söğüt¹,

Acar²

2020

J Lit Pharm Sci

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Doğada borat ve borik asit formu ile su ve toprakta bulunan borun, yakın zamana kadar zehirleyici etkileri daha yaygın olarak bilinse de 1997 yılından beri beslenme ve klinikte önemli rolü gündeme gelmiştir. 1,2 Kuruyemiş (fındık, ceviz, yer fıstığı, badem), meyve (ananas, vişne, üzüm, avokado, kayısı, şeftali) ve sebzelerde (brokoli, havuç, taze fasulye) bulunur. [2][3][4] Bölgesel açıdan farklılıklar gösterse de genel olarak günlük bor alımı 1-7 mg olarak bildirilmiştir. 5Bor, insan vücuduna beslenme, solunum ve sabun, deterjan, kozmetik yolu ile deriden girer. Deriden geçiş, herhangi bir yara yoksa ihmal edilebilir düzeydedir. Borun %85-90'ı, vücuda alındıktan kısa süre sonra değişmeden idrarla atılır, ancak %10-15'lik kısmı boratlar hâlinde bağırsaklardan emilir ve beyin-omurilik sıvısı, kemik, beyin, karaciğer ve yağ dokularında birikir. 4,5 ÖZET Sağlıklı canlıların metabolizmalarında önemli rolü olan bor, bir mikrobesindir. Borun insan sağlığına olan etkilerini özetlersek; (1) Kemiklerin yapısının korunması, büyümesi ve bakımı için önemlidir; (2) Kalsiyum, magnezyum, fosfor ve D vitamini gibi bazı vücut minerallerinin düzenlenmesinde rol alır; (3) Vücudun östrojen ve testosteron kullanımını etkiler; (4) Anti-inflamatuar etki gösterir ve romatoid artrit ile ilişkilidir; (5) Süperoksid dismutaz, katalaz ve glutatyon peroksidaz gibi antioksidan enzimlerin düzeylerini artırır; (6) Elektriksel beyin aktivitesini, bilişsel performansı ve yaşlılarda kısa-dönem hafızayı geliştirir; (7) Yara iyileştirici ve antimikrobiyal etkileri vardır; (8) Prostat, akciğer, meme kanserleri, beyin tümörleri üzerinde koruyucu ve tedavi edici etkileri olduğu bildirilmiştir. Dünya Sağlık Örgütünce sağlıklı erişkin bir bireyin beslenme ile alabileceği bor miktarı 1-13 mg olarak belirlenmiştir. Çeşitli kuruyemişler, baklagiller, meyve ve sebzeler bor açısından zengindir. Osteoporoz, osteoartrit, meme, prostat, akciğer kanserli veya riski olan, yeterli meyve ve sebze tüketmeyen kişilere bor takviyeli beslenme uygulandığında, bu hastalıklarla ilgili olumlu sonuçlar alındığı bildirilmiştir. Aşırı dozda bor alınması durumunda, erişkinlerde baş ağrısı, kusma, ishal, psikolojik sorunlar; çocuklarda havale ve beyin zarı tahribi yapabileceği rapor edilmiştir. Ancak öldürücü dozu aşmak çok zordur. Bu derleme; borun insan sağlığı üzerindeki belirgin etkilerini ve borun yeni tedavilerde kullanımını kapsayan çalışmaları bir araya getirmeye odaklanmıştır. Anah tar Ke li me ler:Bor; sağlık; fayda; terapötik kullanım ABS TRACT Boron, which plays an important role in the metabolism of healthy living organisms, is a micronutrient. To summarize the effect of boron on human health; (1) Is essential for the protection, growth and maintenance of bone; (2) Plays a role in the regulation of some body minerals such as calcium, magnesium, phosphorus and vitamin D;(3) Impacts the body's use of estrogen, testosterone (4) Has anti-imflammatory effect and related with romatoid arthrit; (5) Raises levels of antioxidant enzymes, such as superoxide dismutase, catalas...

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Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era

Cited by 199 publications

References 48 publications

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

Boron neutron capture therapy: Current status and future perspectives

Boron and Health

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