Boron Nano-hydroxyapatite Composite Increases the Bone Regeneration of Ovariectomized Rabbit Femurs

Dede, Eda Çiftci; Korkusuz, Petek; Bilgiç, Elif; Çetinkaya, Mehmet Alper; Korkusuz, Feza

doi:10.1007/s12011-021-02626-0

Cited by 12 publications

(13 citation statements)

References 65 publications

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“…In the histopathological analysis, it was observed that, compared with the control group, strontium placed in the bone cavity and boron added to the strontium had positive effects on new bone formation and osteoblast levels. The results of our study are in line with those of other studies in the literature [ 64 , 65 , 74 , 75 , 76 ]. In addition, different concentrations of boron were used in the repair/regeneration of bone defects in our study.…”

Section: Discussionsupporting

confidence: 93%

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Öztekin

Gürgenç

Dündar

et al. 2022

JFB

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In the present study, the structural, morphological, and in vivo biocompatibility of un-doped and boron (B)-doped strontium apatite (SrAp) nanoparticles were investigated. Biomaterials were fabricated using the hydrothermal process. The structural and morphological characterizations of the fabricated nanoparticles were performed by XRD, FT-IR, FE-SEM, and EDX. Their biocompatibility was investigated by placing them in defects in rat tibiae in vivo. The un-doped and B-doped SrAp nanoparticles were successfully fabricated. The produced nanoparticles were in the shape of nano-rods, and the dimensions of the nano-rods decreased as the B ratio increased. It was observed that the structural and morphological properties of strontium apatite nanoparticles were affected by the contribution of B. A stoichiometric Sr/P ratio of 1.67 was reached in the 5% B-doped sample (1.68). The average crystallite sizes were 34.94 nm, 39.70 nm, 44.93 nm, and 48.23 nm in un-doped, 1% B-doped, 5% B-doped, and 10% B-doped samples, respectively. The results of the in vivo experiment revealed that the new bone formation and osteoblast density were higher in the groups with SrAp nanoparticles doped with different concentrations of B than in the control group, in which the open defects were untreated. It was observed that this biocompatibility and the new bone formation were especially elevated in the B groups, which added high levels of strontium were added. The osteoblast density was higher in the group in which the strontium element was placed in the opened bone defect compared with the control group. However, although new bone formation was slightly higher in the strontium group than in the control group, the difference was not statistically significant. Furthermore, the strontium group had the highest amount of fibrotic tissue formation. The produced nanoparticles can be used in dental and orthopedic applications as biomaterials.

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Section: Discussionsupporting

confidence: 93%

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Öztekin

Gürgenç

Dündar

et al. 2022

JFB

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“…Various methods can be applied to prepare and functionalize CBNMs, including a simple, mild liquid-phase mineralization reaction. ,,− This provides an opportunity to achieve uniform nanomorphology and diversified functionalization of CBNMs using many hydrophilic drugs and organic ingredients via mineralization reactions. CBNMs, especially CaP, are also structurally able to accept many ionic substitutions, such as strontium, ,− cobalt, boron and europium . These substituted inorganic ions not only endow CBNMs with different properties but can also aid in osteoporosis treatment.…”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

“…Various preparation methods allow for the construction of different forms of antiosteoporotic CBNMs. The preparation methods discussed here include coprecipitation, ,,,− ,,,− sol–gel, ,− ,,− ,− hydrothermal, ,,, electrochemical deposition, ,, electrostatic spray deposition, vapor diffusion, sonochemical synthesis, and physical crushing. − Each preparation method has unique advantages and is accordingly suitable for the preparation of specific forms of CBNMs. The physicochemical properties of CBNMs prepared by different methods are summarized in Table .…”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

“…Changing the reaction conditions, such as pH, ion concentration, reaction time, solvent type, and additives, will affect the properties of the final CBNMs. ,− It is also possible to incorporate other ingredients into CBNMs by adding them to the reaction system. Most commonly, specific inorganic ions, such as strontium and boron, are added to build ion-doped CBNMs endowed with specific functions. For instance, strontium, an element with a dual effect on both osteoblasts and osteoclasts, can be incorporated into nano-CaPs by introducing soluble strontium salt into the coprecipitation reaction system containing calcium and phosphate .…”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

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Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Deng

Wei

Tang

2022

ACS Biomater. Sci. Eng.

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With rapidly aging populations worldwide, osteoporosis has become a serious global public health problem. Caused by disordered systemic bone remodeling, osteoporosis manifests as progressive loss of bone mass and microarchitectural deterioration of bone tissue, increasing the risk of fractures and eventually leading to osteoporotic fragility fractures. As fracture risk increases, antiosteoporosis treatments transition from nonpharmacological management to pharmacological intervention, and finally to the treatment of fragility fractures. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment because of several characteristics including similarity to natural bone, excellent biocompatibility, easy preparation and functionalization, low pH-responsive disaggregation, and inherent pro-osteogenic properties. By combining additional ingredients, CBNMs can play multiple roles to construct antiosteoporotic biomaterials with different forms. This review covers recent advances in CBNMs for osteoporosis treatment. For ease of understanding, CBNMs for antiosteoporosis treatment can be classified as locally applied CBNMs, such as implant coatings and filling materials for osteoporotic bone regeneration, and systemically administered CBNMs for antiosteoporosis treatment. Locally applied CBNMs for osteoporotic bone regeneration develop faster than the systemically administered CBNMs, an important consideration given the serious outcomes of fragility fractures. Nevertheless, many innovations in construction strategies and preparation methods have been applied to build systemically administered CBNMs. Furthermore, with increasing interest in delaying osteoporosis progression and avoiding fragility fracture occurrence, research into systemic administration of CBNMs for antiosteoporosis treatment will have more development prospects. Deep understanding of the CBNM preparation process and optimizing CBNM properties will allow for increased application of CBNMs in osteoporosis treatments in the future.

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“…HA and Collagen together account for approximately 95% of natural bone under dry conditions 29. Nano-HA composite has been shown to increase the bone regeneration in the femur of ovariectomized rabbit 30. In addition, the in situ fabricated HA/Co scaffold has been recently suggested as a proper approach scaffold with similar properties like bone 11.…”

mentioning

confidence: 99%

Comparison capacity of collagen hydrogel, mix‐powder and in situ hydroxyapatite/collagen hydrogelscaffolds with and without mesenchymal stem cells and platelet‐rich plasma in regeneration of critical sized bone defect in a rabbit animal model

et al. 2021

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The aim of this study was to investigate the effect of developed collagen (Co) hydrogel (CH), powder-mixed hydroxyapatite/collagen (HA/Co) hydrogel and in situ synthesized HA/Co (In/HA/Co) hydrogel with or without mesenchymal stem cell (MSC) and platelet-rich plasma (PRP) on the regeneration of fullthickness critical size bone defect in the rabbit animal model. In the first step of this study, the scaffolds were synthesized and characterized using FTIR spectroscopy, X-ray diffraction, and scanning electron microcopy. In the second step or animal study, the radial bone defects were filled with the synthesized scaffolds with and without MSC and PRP. One hundred sixty one year-old New Zealand white male rabbits were randomly divided in 16 groups of 10 rabbits including control

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Boron Nano-hydroxyapatite Composite Increases the Bone Regeneration of Ovariectomized Rabbit Femurs

Cited by 12 publications

References 65 publications

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Comparison capacity of collagen hydrogel, mix‐powder and in situ hydroxyapatite/collagen hydrogelscaffolds with and without mesenchymal stem cells and platelet‐rich plasma in regeneration of critical sized bone defect in a rabbit animal model

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