Boron Imaging: Localized Quantitative Detection and Imaging of Boron by Magnetic Resonance

Bendel, Peter

doi:10.1007/978-3-642-31334-9_12

Cited by 3 publications

(2 citation statements)

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“…With the recent advent of hospital-based neutron sources for BNCT, prospective studies with larger patient cohorts can now be performed and should include evaluation of multimodality quantitative imaging to assess treatment response to provide a robust investigation of their efficacy. It also opens up the possibility of further developing the methods specifically for BNCT, which have shown promise in the early stages [ 33 , 34 , 35 , 36 ], for clinical use.…”

Section: Multi-modal Imaging For Treatment Optimization and Response Evaluationmentioning

confidence: 99%

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Theranostics in Boron Neutron Capture Therapy

Sauerwein

Sancey

Hey‐Hawkins

et al. 2021

Life

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Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues infiltrated by the tumor. BNCT is a binary treatment method based on the combination of two agents that have no effect when applied individually: 10B and thermal neutrons. Exclusively, the combination of both produces an effect, whose extent depends on the amount of 10B in the tumor but also on the organs at risk. It is not yet possible to determine the 10B concentration in a specific tissue using non-invasive methods. At present, it is only possible to measure the 10B concentration in blood and to estimate the boron concentration in tissues based on the assumption that there is a fixed uptake of 10B from the blood into tissues. On this imprecise assumption, BNCT can hardly be developed further. A therapeutic approach, combining the boron carrier for therapeutic purposes with an imaging tool, might allow us to determine the 10B concentration in a specific tissue using a non-invasive method. This review provides an overview of the current clinical protocols and preclinical experiments and results on how innovative drug development for boron delivery systems can also incorporate concurrent imaging. The last section focuses on the importance of proteomics for further optimization of BNCT, a highly precise and personalized therapeutic approach.

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Section: Multi-modal Imaging For Treatment Optimization and Response Evaluationmentioning

confidence: 99%

“…In principle, MRI imaging and MRI spectroscopy can also be used to detect the currently available boron compounds, namely BSH and BPA, although this requires special software and hardware requirements that are not currently available for clinical use [ 33 , 34 , 35 , 36 ].…”

Section: Further Diagnostic Possibilities For Theranostic Approaches In Bnctmentioning

confidence: 99%