Boron-Doped Nanodiamonds as Anticancer Agents: En Route to Hyperthermia/Thermoablation Therapy

Vervald, Alexey M.; Burikov, Sergey; Scherbakov, Alexander M.; Kudryavtsev, Oleg; Kalyagina, Nina; Власов, И. И.; Екимов, Е. А.; Dolenko, Tatiana A.

doi:10.1021/acsbiomaterials.0c00505

Cited by 19 publications

(15 citation statements)

References 41 publications

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“…Under continuous irradiation of 808 nm with a laser diode of an intensity of 50 W•cm −2 for 20 min, the time-dependent temperature rise was recorded, as shown in Figure 1b; a temperature rise of 15 • C was observed in the BNDs' solution under an 808 nm laser illumination for 20 min, in contrast to 2 • C observed in the undoped NDs' solution under the same laser irradiation for the same period of time. This is in agreement with prior work identifying BNDs as promising anticancer agents, as reported in [13]. Next, after verifying the heating ability of the lightly doped BNDs, it was important to investigate whether the BNDs could still function for quantum sensing applications, especially for temperature sensing [1].…”

Section: Resultssupporting

confidence: 84%

“…Exploring quantum sensing using the NV color center in BNDs is of special interest due to the recent successful implementation of BNDs as an anticancer agent via hyperthermia/thermoablation therapy [13]. This study reports that BNDs can selectively heat the local environment, for example, in tumor cells, without heating the surrounding tissue by exciting it with NIR lasers (808 nm) in the tissue transparency window.…”

Section: Introductionmentioning

confidence: 99%

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Lightly Boron-Doped Nanodiamonds for Quantum Sensing Applications

et al. 2022

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Unlike standard nanodiamonds (NDs), boron-doped nanodiamonds (BNDs) have shown great potential in heating a local environment, such as tumor cells, when excited with NIR lasers (808 nm). This advantage makes BNDs of special interest for hyperthermia and thermoablation therapy. In this study, we demonstrate that the negatively charged color center (NV) in lightly boron-doped nanodiamonds (BNDs) can optically sense small temperature changes when heated with an 800 nm laser even though the correct charge state of the NV is not expected to be as stable in a boron-doped diamond. The reported BNDs can sense temperature changes over the biological temperature range with a sensitivity reaching 250 mK/√Hz. These results suggest that BNDs are promising dual-function bio-probes in hyperthermia or thermoablation therapy as well as other quantum sensing applications, including magnetic sensing.

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Section: Resultssupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Lightly Boron-Doped Nanodiamonds for Quantum Sensing Applications

et al. 2022

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“…In this region, the therapeutic effect might be induced by excessive tumor heating caused by light energy absorption [7,8], which was demonstrated to be efficient against skin cancer [9,10]. In hyperthermia, an additional absorption contrast between healthy and pathological tissues can be achieved by the targeted delivery of nanoagents to treatment areas [11][12][13]. Since nanoparticle (NP) shape and material determine its absorption spectra, the nanoparticles could be customized to provide additional absorption at the applied laser wavelength, thus enhancing the absorption contrast upon target delivery.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

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Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power.

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“…These nanostructures were proven to be more efficient than nanodiamonds obtained by detonation due to their significant capacity to absorb infrared light, which hold promise for their use in hyperthermia and thermoablation of tumors. (48). In other studies, drugs such as melittin, the main component of bee venom, have been tested.…”

Section: Nanodiamondsmentioning

confidence: 99%

Nanomaterials for Breast Cancer

Orrantia‐Borunda¹,

Acuña-Aguilar²,

Ramírez-Valdespino³

2022

Breast Cancer

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Breast cancer represents 16% of all malignant tumors diagnosed and is the leading cause of mortality in women worldwide. While significant advances in the diagnosis and treatment of breast cancer have been made over the years, the management of advanced stages of the disease and treatment-related adverse events continue to be a challenge. There is a need to develop tools for target-specific delivery of drugs to improve efficiency and decrease non-specific drug-induced Note to the Reader: This chapter is part of the book Breast Cancer (ISBN: 978-0-6453320-3-2), scheduled for publication in July 2022. The book is being published by Exon Publications,

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Boron-Doped Nanodiamonds as Anticancer Agents: En Route to Hyperthermia/Thermoablation Therapy

Cited by 19 publications

References 41 publications

Lightly Boron-Doped Nanodiamonds for Quantum Sensing Applications

Lightly Boron-Doped Nanodiamonds for Quantum Sensing Applications

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Nanomaterials for Breast Cancer

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