Boron and gadolinium neutron capture therapy

Abstract

The principles of neutron capture therapy of tumor diseases, the types of drugs, and the results of their clinical applications are discussed.

MRI‐Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low‐Density Lipoprotein Transporters

“…In particular, 157 Gd thermal neutron cross-section yields a 65-fold improvement upon 10 B atoms. [13] Results Formation of Gd/B/L/adducts: Scheme 1 shows the structure of the dual Gd/B agent, namely, the gadolinium/boron/ ligand (Gd/B/L) adduct, used in this study. The synthesis of the ligand consists of 14 steps and has already been reported.…”

Study of the response of phenol compounds exposed to thermal neutrons beams for Electron Paramagnetic Resonance dosimetry

“…In the last years, the development of Neutron Capture Therapy (NCT) (Sauerwein et al, 2012;Salt et al, 2004) for cancer treatments has stimulated the research on beam characterization in order to optimize the therapy procedures. The success of radiation therapy in treating cancer depends on the delivery of lethal radiation dose to the tumor, with as little as possible harm to surrounding tissues (Khan, 2010;Shani, 2000).…”

“…The choice of gadolinium as the additive nucleus has been made because we are interested in applications for mixed field (neutrons/photons) EPR dosimetry (Marrale et al, 2008a(Marrale et al, , 2014c(Marrale et al, , 2013a(Marrale et al, , 2011a. Gadolinium has a high neutron capture cross section and, furthermore, the high Linear Energy Transfer (LET) secondary particles (in particular, the Auger electrons) release their energy entirely inside the dosimeter volume (Salt et al, 2004;Marrale et al, 2007b). The low content of gadolinium guarantees a good trade-off between the sensitivity to thermal neutrons and the reduction of tissue equivalence.…”

Synthesis of magnetic GdC2 nanoparticles using cavitation plasma

“…Among all these applications, Gd is a promising candidate as neutron capture therapy (NCT) agent and has been receiving wide attention due to its highest neutron crosssection (255,000 barns), which is around 65 times larger compared to boron thermal neutron cross-section [6][7][8]. Gd is already used as MRI contrast enhancing agent in clinical investigations.…”