Boroaluminosilicate glasses as ion exchange materials

Ramkumar, Jayshree; Chandramouleeswaran, S.; Sudarsan, V.; Vatsa, R.K.; Shobha, S; Shrikhande, V.K.; Kothiyal, G.P.; Mukherjee, Tulsi

doi:10.1016/j.jnoncrysol.2010.09.053

Cited by 18 publications

(10 citation statements)

References 19 publications

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“…14 In borosilicate glasses, a lower B 2 O 3 /Na 2 O ratio seems to favor the staining process, due to the presence of more exchangeable ions. 15 The deep coloration of F vials in the bottom near wall region agrees with the idea that the weaker regions of vials, where delamination might occur, are those where tubing vials experience the higher working temperature during the manufacturing process. This result confirms what was already found in the previous work.…”

Section: Aggressive Test Protocolsupporting

confidence: 79%

“…The mechanism of staining has been reported to be related to ion exchange between cations in the glass and the dye in the solution, favored by surface diffusion within the corroded glass through pores or cracks 14 . In borosilicate glasses, a lower B 2 O 3 /Na 2 O ratio seems to favor the staining process, due to the presence of more exchangeable ions 15 …”

Section: Discussionmentioning

confidence: 99%

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Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

Guglielmi

Bessegato²,

Cerdan‐Diaz³

et al. 2020

Int J of Appl Glass Sci

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This paper is the result of two round robin activities run by the Technical Committee TC12, Pharma Packaging, of the International Commission on Glass (ICG). It deals with the phenomenon of delamination, that is, the formation of lamellae or flakes in drug products due to specific and localized corrosion of glass vials, and it follows a first paper PDA J Pharm Sci Technol. 2018, 72, 553-565where a testing protocol for the evaluation of the delamination propensity was proposed. The results showed that the protocol gives information on the quality of vials with respect to the propensity to corrosion, but no direct correlation with delamination could be demonstrated, as no lamellae formation was observed. In response, further testing was carried out on five sets of vials with expected low delamination propensity, compared to a set of vials with high expected delamination propensity using both the proposed protocol and a more aggressive protocol. The objective was to observe lamellae at least in the high propensity vials to show a correlation to initial test protocols.

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Section: Aggressive Test Protocolsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

Guglielmi

Bessegato²,

Cerdan‐Diaz³

et al. 2020

Int J of Appl Glass Sci

View full text Add to dashboard Cite

show abstract

“…[38] To study this effect, a known amount of the sorbent (7 mg) was equilibrated with RhB, MB, MG, and MO dye solutions of known concentration (20 ppm) maintained at various pH values for different equilibration periods. A weighed amount of the α-Ag 2 WO 4 nanorods was equilibrated with a solution containing a known concentration of the dye (RhB/ MB/MG/MO) maintained at a particular pH for a known period of time.…”

Section: Dye Adsorption Studiesmentioning

confidence: 99%

High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag₂WO₄ Nanorods

et al. 2014

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Keywords: Silver / Tungsten / Nanostructures / Adsorption / Cationic dyes / Antibacterial activity α-Ag 2 WO 4 nanorods with an average diameter of 15 to 25 nm and a surface area of ca. 115.0 Ϯ 0.2 m 2 /g have been synthesized by a facile sonochemical technique. These nanorods have been used for the adsorption of various cationic dyes (rhodamine B, methylene blue, and malachite green) from aqueous solution. The adsorption process is fast, and ca. 100 % adsorption of a 20 ppm mixture of all three dyes occurs within 10 min. The adsorption process was studied by varying different regulating parameters such as the solution pH and the initial dye and Ag 2 WO 4 concentrations, and the results were analyzed with various isotherm and kinetic models. The mechanistic pathway for the selective adsorption of cationic dyes has been explained through zeta potential [a]

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“…Methylene blue, a cationic dye, interacts with glass via adsorption dominated by an ion-exchange mechanism (13,14). Pure silica tetrahedrons are very brittle, and oxides of sodium, Fig.…”

Section: Methylene Blue Stainingmentioning

confidence: 99%

Glass Delamination: a Comparison of the Inner Surface Performance of Vials and Pre-filled Syringes

Zhao¹,

Lavalley

Mangiagalli

et al. 2014

AAPS PharmSciTech

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The occurrence of glass delamination is a serious concern for parenteral drug products. Over the past several years, there has been a series of product recalls involving glass delamination in parenteral drugs stored in vials which has led to heightened industry and regulatory scrutiny. In this study, a two-pronged approach was employed to assess the inner surface durability of vials and pre-filled syringes. Non-siliconized syringes were used in order to directly compare glass to glass performance between vials and syringes. The vial and syringe performance was screened with pharmaceutically relevant formulation conditions. The influence of pH, buffer type, ionic strength, and glass type and source was evaluated. In addition, an aggressive but discriminating formulation condition (glutaric acid, pH 11) was used to ascertain the impact of syringe processing. Advanced analytical tools including inductively coupled plasma/mass spectrometry, scanning electron microscopy, atomic force microscopy, and dynamic secondary ion mass spectroscopy showed significant differences in glass performance between vials and syringes. Pre-filled syringes outperform vials for most tests and conditions. The manufacturing conditions for vials lead to glass defects, not found in pre-filled syringes, which result in a less chemically resistant surface. The screening methodology presented in this work can be applied to assess suitability of primary containers for specific drug applications.

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Boroaluminosilicate glasses as ion exchange materials

Cited by 18 publications

References 19 publications

Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag₂WO₄ Nanorods

Glass Delamination: a Comparison of the Inner Surface Performance of Vials and Pre-filled Syringes

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Boroaluminosilicate glasses as ion exchange materials

Cited by 18 publications

References 19 publications

Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use

High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag2WO4 Nanorods

Glass Delamination: a Comparison of the Inner Surface Performance of Vials and Pre-filled Syringes

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Product

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High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag₂WO₄ Nanorods