Borneol reduces sympathetic vasomotor hyperactivity and restores depressed baroreflex sensitivity in rats with renovascular hypertension

Luz, Mickael Sousa da; Gadelha, Danilo D. A.; Andrade, Kaio J. S.; Travassos, Renata A.; Ribeiro, Juliene D.; Carvalho‐Galvão, Alynne; Cruz, José Jaime da; Balarini, Camille M.; Braga, Valdir de Andrade; França-Falcão, Maria S.

doi:10.1038/s41440-022-00868-6

Cited by 4 publications

(5 citation statements)

References 40 publications

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“…For example, (−)-borneol was recently reported to exhibit antibacterial activity [ 69 ]. (−)-Borneol was also reported to have neuroprotective effects in a middle cerebral artery occlusion (MCAO) model [ 70 , 71 ], as well as vasorelaxant properties, which may be attributed to Ca 2+ influx blockade through voltage-gated Ca 2+ channels, Ca 2+ mobilization from intracellular stores, and activation of K + channels [ 72 , 73 , 74 ]. Store-independent Ca 2+ channels that exist in various hematopoietic cells, including neutrophils, are pharmacologically and/or immunologically similar to voltage-gated Ca 2+ channels [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

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Neutrophil Immunomodulatory Activity of (−)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa

Schepetkin

Özek

et al. 2022

Molecules

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Grindelia squarrosa (Pursh) Dunal is used in traditional medicine for treating various diseases; however, little is known about the immunomodulatory activity of essential oils from this plant. Thus, we isolated essential oils from the flowers (GEOFl) and leaves (GEOLv) of G. squarrosa and evaluated the chemical composition and innate immunomodulatory activity of these essential oils. Compositional analysis of these essential oils revealed that the main components were α-pinene (24.7 and 23.2% in GEOFl and GEOLv, respectively), limonene (10.0 and 14.7%), borneol (23.4 and 16.6%), p-cymen-8-ol (6.1 and 5.8%), β-pinene (4.0 and 3.8%), bornyl acetate (3.0 and 5.1%), trans-pinocarveol (4.2 and 3.7%), spathulenol (3.0 and 2.0%), myrtenol (2.5 and 1.7%), and terpinolene (1.7 and 2.0%). Enantiomer analysis showed that α-pinene, β-pinene, and borneol were present primarily as (−)-enantiomers (100% enantiomeric excess (ee) for (−)-α-pinene and (−)-borneol in both GEOFl and GEOLv; 82 and 78% ee for (−)-β-pinene in GEOFl and GEOLv), while limonene was present primarily as the (+)-enantiomer (94 and 96 ee in GEOFl and GEOLv). Grindelia essential oils activated human neutrophils, resulting in increased [Ca2+]i (EC50 = 22.3 µg/mL for GEOFl and 19.4 µg/mL for GEOLv). In addition, one of the major enantiomeric components, (−)-borneol, activated human neutrophil [Ca2+]i (EC50 = 28.7 ± 2.6), whereas (+)-borneol was inactive. Since these treatments activated neutrophils, we also evaluated if they were able to down-regulate neutrophil responses to subsequent agonist activation and found that treatment with Grindelia essential oils inhibited activation of these cells by the N-formyl peptide receptor 1 (FPR1) agonist fMLF and the FPR2 agonist WKYMVM. Likewise, (−)-borneol inhibited FPR-agonist-induced Ca2+ influx in neutrophils. Grindelia leaf and flower essential oils, as well as (−)-borneol, also inhibited fMLF-induced chemotaxis of human neutrophils (IC50 = 4.1 ± 0.8 µg/mL, 5.0 ± 1.6 µg/mL, and 5.8 ± 1.4 µM, respectively). Thus, we identified (−)-borneol as a novel modulator of human neutrophil function.

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Section: Resultsmentioning

confidence: 99%

“…The logP values estimated using ALOGPS 2.1 program [ 78 ] and tPSA values allowed us to predict that borneol can permeate the blood–brain barrier (BBB) ( Table 4 ). It should be noted that (−)-borneol itself can also increase blood–brain barrier permeability [ 73 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

Neutrophil Immunomodulatory Activity of (−)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa

Schepetkin

Özek

et al. 2022

Molecules

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“…The main active ingredients of traditional Chinese medicine borneol include borneol, isoproterenol, etc. A large number of studies have found that its active ingredients have anti-inflammatory, antioxidant, anti apoptotic, anticoagulant activity, improving energy metabolism, relaxing blood vessels, regulating blood pressure, improving intracellular lipid accumulation, sedation and pain relief, protecting myocardial tissue, and alleviating autophagy and apoptosis of myocardial cells [ [96] , [97] , [98] , [99] , [100] , [101] , [102] ].…”

Section: The Composition Principle and Main Active Ingredients Of Ton...mentioning

confidence: 99%

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Xin,

Wang,

Hou

et al. 2024

Heliyon

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“…Among the terpenic compounds in the Eryngium species of the central-western region of Mexico (described in E. carlinae , Table 6 ), are the borneol and α- and β-pinene, which are present in the essential oils of several aromatic plants and show activity on blood pressure regulation [ 134 ] in addition to showing cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects as well as their effects against H 2 O 2 -stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain [ 135 ]. Regarding caryophyllene (β-Caryophyllene (BCP)) and farnesene, they are natural sesquiterpenes that have several biological activities such as antimicrobial, anticarcinogenic, anti-inflammatory, antioxidant, anxiolytic-like, and local anesthetic effects.…”

Section: Phytochemistrymentioning

confidence: 99%

Ethnobotany, Biological Activities and Phytochemical Compounds of Some Species of the Genus Eryngium (Apiaceae), from the Central-Western Region of Mexico

et al. 2023

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There are approximately 250 species of Eryngium L. distributed throughout the world, with North America and South America being centers of diversity on this continent. In the central-western region of Mexico there may be around 28 species of this genus. Some Eryngium species are cultivated as leafy vegetables, ornamental, and medicinal plants. In traditional medicine they are used to treat respiratory and gastrointestinal conditions, diabetes, and dyslipidemia, among others. This review addresses the phytochemistry and biological activities, as well as traditional uses, distribution, and characteristics of the eight species of Eryngium reported as medicinal in the central-western region of Mexico: E. cymosum, E. longifolium, E. fluitans (or mexicanum), E. beecheyanum, E. carlinae, E. comosum, E. heterophyllum, and E. nasturtiifolium. The extracts of the different Eryngium spp. have shown biological activities such as hypoglycemic, hypocholesterolemic, renoprotective, anti-inflammatory, antibacterial, and antioxidant, among others. E. carlinae is the most studied species, and phytochemical analyses, performed mainly by high-performance liquid chromatography (HPLC) and gas chromatography coupled with mass spectrometry (GC-MS), have shown its content of terpenoids, fatty acids, organic acids, phenolic acids, flavonoids, sterols, saccharides, polyalcohols, and aromatic and aliphatic aldehydes. According to the results of this review on Eryngium spp., they constitute a relevant alternative as a source of bioactive compounds for pharmaceutical, food, and other industries. However, there is a lot of research to be conducted regarding phytochemistry, biological activities, cultivation, and propagation, in those species with few or no reports.

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Borneol reduces sympathetic vasomotor hyperactivity and restores depressed baroreflex sensitivity in rats with renovascular hypertension

Cited by 4 publications

References 40 publications

Neutrophil Immunomodulatory Activity of (−)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa

Neutrophil Immunomodulatory Activity of (−)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Ethnobotany, Biological Activities and Phytochemical Compounds of Some Species of the Genus Eryngium (Apiaceae), from the Central-Western Region of Mexico

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