Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells

Hur, Jinyoung; Pak, Sok Cheon; Koo, Byung-Soo; Jeon, Songhee

doi:10.3109/13880209.2012.700718

Cited by 46 publications

(30 citation statements)

References 29 publications

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“…An extract of Ginkgo biloba attenuated ATP deficits and decreased oxidative damage following chemically-induced mitochondrial damage in PC12 neuronal cells [44], and stabilized mitochondrial function against nitrosative stress in primary neurons [45]. In SH-SY5Y cells, xanthoceraside, a compound extracted from Chinese flowering chestnuts, prevented Aβ-induced ROS generation, calcium overload and mitochondrial dysfunction [41] and borneol, found in many plants including wormwood and sagebrush, also decreased Aβ-induced ROS production by activating NFE2L2 [46]. …”

Section: Discussionmentioning

confidence: 99%

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Gray

Sampath

Zweig

et al. 2015

JAD

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Background We previously showed that a water extract of the medicinal plant Centella asiatica (CAW) attenuates β-amyloid (Aβ)-induced cognitive deficits in vivo, and prevents Aβ-induced cytotoxicity in vitro. Yet the neuroprotective mechanism of CAW is unknown. Objective The goal of this study was to identify biochemical pathways altered by CAW using in vitro models of Aβ toxicity. Methods The effects of CAW on aberrations in antioxidant response, calcium homeostasis and mitochondrial function induced by Aβ were evaluated in MC65 and SH-SY5Y neuroblastoma cells. Results CAW decreased intracellular ROS and calcium levels elevated in response to Aβ, and induced the expression of antioxidant response genes in both cell lines. In SH-SY5Y cells, CAW increased basal and maximal oxygen consumption without altering spare capacity, and attenuated Aβ-induced decreases in mitochondrial respiration. CAW also prevented Aβ –induced decreases in ATP and induced the expression of mitochondrial genes and proteins in both cell types. Caffeoylquinic acids from CAW were shown to have a similar effect on antioxidant and mitochondrial gene expression in neuroblastoma cells. Primary rat hippocampal neurons treated with CAW also showed an increase in mitochondrial and antioxidant gene expression. Conclusions These data suggest an effect of CAW on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes and normalizing calcium homeostasis, likely contributes to its neuroprotective action against Aβ toxicity.

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Section: Discussionmentioning

confidence: 99%

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Gray

Sampath

Zweig

et al. 2015

JAD

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“…Previous studies showed that borneol has free radical scavenging activity (95) and is a major component of essential oil of SuHeXiang Wan (92) whose neuroprotective function has been reported in in vivo and in vitro models of Alzheimer’s disease (AD) (96–99). Moreover, a recent study showed that borneol exerts a neuroprotective effect against β-amyloid (Aβ) cytotoxicity via upregulation of nuclear translocation of Nrf2 and expression of Bcl-2 (100). In addition, treatment with isoborneol, a monoterpenoid alcohol, significantly reduced 6-hydroxydopamine-induced ROS generation and cell death in human neuroblastoma SH-SY5Y cells, suggesting that isoborneol may be a potential therapeutic agent for treatment of neurodegenerative diseases associated with oxidative stress (101).…”

Section: Terpenes and Neuronal Healthmentioning

confidence: 99%

Terpenes from Forests and Human Health

et al. 2017

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Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

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“…For example, neuronsKarkkainen et al, 2014). In addition, the ability of Nrf2 to upregulate the expression of anti-oxidant genes 720 via ARE suggests that increasing Nrf2 activity may pro-721 vide a useful system for combating oxidative insults.Several recent reports have demonstrated that coordi-723 nated upregulation of ARE-driven genes protects SH-SY5Y cells from Ab-induced neurotoxicity(Lee et al, 725 2011;Wang et al, 2012;Hur et al, 2013).Nrf2-activating compounds, the usefulness of these mole-731 cules in disease is unclear due to a lack of information 732 regarding their ability to enter the central nervous system. Thus, in the search for compounds that activate Nrf2 sig-…”

mentioning

confidence: 98%

Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25–35 neurotoxicity

Kwon

Hwang

et al. 2015

Neuroscience

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Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells

Cited by 46 publications

References 29 publications

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

Terpenes from Forests and Human Health

Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25–35 neurotoxicity

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