Boric acid in magnetized water: clean and powerful media for synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Abstract

Water was magnetized via an external magnetic field and employed, for the first time, as a solvent in green preparation of 3,4-dihydropyrimidin-2(1H)-ones by the one-pot three-component condensation reaction using boric acid as a catalyst.

Efficient Synthesis of Dihydropyrimidines Using a Highly Ordered Mesoporous Functionalized Pyridinium Organosilica

“…Due to remarkable biological and pharmacological activities and versatile use of DHPMs, the synthesis of DHPMs has been revalued. Several improved synthetic methodologies for the Biginelli condensation have recently been developed by employing various catalysts such as p-toluenesulfonic acid [16], Ni(II) coordination complex [17], chloroacetic acid [18], TiCl 4 [19], RuCl 3 [20], Sc(OTf) 3 [21], Co(OAc) 2 [22], sulfated zirconia [23], FeCl 3 .6H 2 O [24], MgBr 2 [25], NbCl 5 [26], Yb(OTf) 3 [27], InCl 3 [28], CuCl 2 [29], SnCl 2 [30], BF 3 .OEt 2 [31], ZrCl 4 [32], ZnCl 2 [33], TMSOTf [34], CdCl 2 [35], CH 3 SO 3 H [36], Iron(III) [37], SmI 2 [38], Pb(NO 3 ) 3 [39], Ba(OH) 3 [40], solvent-free synthesis [41], microwave irradiation [42], ultrasound radiation [43], visible light irradiation [44], Brønsted acidic ionic liquid [45], solid supported reagent [46][47][48][49][50], and enzymatic catalysts [51]. In spite of progress in the synthesis of these compounds, however, some of the previously reported procedures have significant drawbacks such as harsh reaction conditions, low product yield, use of expensive or toxic reagents, laborious workup, and large amount of toxic wastes generation.…”

Silver molybdate (Ag‐PMo12) nanocomposite: An efficient catalyst for the one‐pot synthesis of 3,3‐diindolyl derivatives in aqueous medium

“…In this context, modified phosphomolybdic acid nanocomposites are introduced as an inexpensive and nonhazardous heterogeneous catalyst for the preparation of various highly functionalized heterocyclic compounds. [9] Very recently, our research group has developed an efficient cross-dehydrogenative coupling (CDC) using Cu-PMo 12 catalyst for the synthesis of novel pyrimidinyl carbamate compounds under mild conditions. [10] With the continuation of our research development of simple and practical synthetic methods, [11] we have synthesized an effective silver-supported heterogeneous catalyst (Ag-PMo 12 ) for the condensation reactions of isatin and indoles providing the 3,3-di(indolyl)oxindoles in aqueous medium and at room temperature (Scheme 1).…”

Visible-Light-Induced Radical Condensation Cyclization to Synthesize 3,4-Dihydropyrimidin-2-(1H)-ones/thiones Using Photoexcited Na2 Eosin Y as a Direct Hydrogen Atom Transfer (HAT) Catalyst

“…Numerous strategies are available. − Numerous instances occurred from these treatments. However, certain synthesis routes have drawbacks, such as limitations on the use of metal catalysts, severe reaction conditions, costly reagents, repetitive workup, low yield, prolonged reaction time, and environmental hazards.…”