Boric acid as a protector against paclitaxel genotoxicity.

Türkez, Hasan; Tatar, Abdülgani; Hacımüftüoğlu, Ahmet; Ozdemir, Ebru Marzioglu

doi:10.18388/abp.2010_2378

Cited by 61 publications

(29 citation statements)

References 23 publications

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“…At the end of the study, it was determined that COL had no geno-toxic damage potential. These results are in line with the previous findings showing that boron compounds (such as borax, boric acid) are non-genotoxic in cultured human blood cells (Turkez et al, 2007, Turkez, Tatar, Hacimuftuoglu, & Ozdemir, 2010Geyikoglu & Turkez 2008;Turkez, 2008;Celikezen et al, 2014;. Gülsoy, Yavas, & Mutlu (2018), was expressed in their study; the same type of borax and boric acid compounds may differ significantly depending on the time (increase in toxicity at 24 hours and decrease in 48, 72 and 96 hours).…”

Section: Micronucleus In Zebrafish Erythrocytessupporting

confidence: 93%

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

Alak¹,

Parlak²,

Uçar³

et al. 2020

Turkish Journal of Fisheries and Aquatic Sciences

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Recently, boron has been used in animal feeding due to its significant biological roles. In this study, the action mechanism of colemanite (COL), a commercially important borate mineral, was aimed to investigate via evaluating parameters related to oxidative alterations on the brain, liver and blood tissues of zebrafish. For this purpose, zebrafish were exposed to different doses of COL (5, 10 and 20 mg/L) in a static test apparatus for 96 hours. Multiple biochemical analysis including determination of DNA damage (8-OHdG), apoptosis (Caspase-3), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), myeloperoxidase (MPO), paraoxonase (PON), arylesterase (AR) and lipid peroxidation (MDA) levels were performed in brain and liver tissues for assessing oxidative responses. In addition to micronucleus (MN) assay was performed in obtained blood tissues. The results indicated that low doses of COL supported antioxidant system and did not lead to oxidative stress in zebrafish brain and liver. Again, our results showed colemanite did not cause DNA damage or apoptosis at all tested concentrations. Besides the statistically insignificant changes (P>0.05) of MN rates of erythrocytes between the control and experimental groups revealed the non-genotoxic feature of COL on zebrafish. In conclusion, boron compounds especially COL can be used safely and provide positive impacts on aquatic environments.

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Section: Micronucleus In Zebrafish Erythrocytessupporting

confidence: 93%

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

Alak¹,

Parlak²,

Uçar³

et al. 2020

Turkish Journal of Fisheries and Aquatic Sciences

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“…In this study, the combination of hollow BNs-b spheres with PTX drugs shows most effective antitumour efficacy among all the groups owing to the synergetic effects of hollow BN spheres and PTX drugs. In addition, BA was reported to help protect against genotoxicity and cytotoxicity in lymphocytes induced by PTX55.…”

Section: Discussionmentioning

confidence: 99%

Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment

et al. 2017

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High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment.

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“…From a clinical perspective, the study provides anticipated rationale for the clinical side effects of taxol. In human cancer patients, taxol-induced lymphocyte toxicity (27), neutropenia (4), testicular shrinkage (28), and ovarian damage (29), are potentially correlated with the endogenous GT198 protein expression specifically in testis, ovary, spleen, and thymus (16,22). The acute taxol toxicity in rodents was also found in ovary (30), testis, hematopoietic, and lymphoid systems (31).…”

Section: Discussionmentioning

confidence: 99%

Oncoprotein GT198 is a direct target of taxol

Yang

Gurvich²,

Gupta

et al. 2019

Preprint

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Taxol (paclitaxel) is one of the most successful chemotherapeutic drugs in the treatment of human cancer. It has recently been questioned whether the mechanism of action in mitotic arrest, which is ubiquitously present in all cells, is sufficient to explain the tumor specificity, clinical efficacy, and side effects of taxol. In this report, we have identified a new protein target of taxol as GT198 (gene symbol PSMC3IP, also known as Hop2). GT198 is an oncoprotein and a DNA repair factor involved in human common solid tumors. The GT198 gene carries germline mutations in breast and ovarian cancer families and recurrent somatic mutations in tumor microenvironment. Mutant GT198 was identified in pericyte stem cells on capillary blood vessels inducing tumor angiogenesis. GT198 is a DNA-binding protein dimer, also stimulates DNA repair, regulates meiosis, participates in homologous DNA recombination, and activates nuclear receptormediated gene expression. Here we show that taxol directly binds to the DNA-binding domain of GT198 in vitro. Taxol serves as an allosteric inhibitor to block DNA binding to GT198 with an IC50 of 8.6 nM. Labeled taxol colocalizes with GT198 in interphase nuclei of cultured cells. Decreased GT198 expression desensitizes taxolinduced cell death, and taxol inhibits GT198 nuclear foci formation during DNA repair.Together, these results demonstrate that GT198 is a previously unrecognized direct protein target of taxol. The finding of taxol target as an oncoprotein GT198 in common solid tumors provides a rationale for the clinical efficacy of taxol. We anticipate that GT198 may serve as a clinical predictive marker of taxol efficacy as well as a new drug target for future anti-cancer therapy.

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Boric acid as a protector against paclitaxel genotoxicity.

Cited by 61 publications

References 23 publications

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment

Oncoprotein GT198 is a direct target of taxol

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