Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer

Chang, Junn Liang; Chen, Ting‐Hsuan; Wang, Chia Fang; Chiang, Yi Hsuan; Huang, Yeu‐Shiang; Wong, Fen Hwa; Chou, Chen Kung; Chen, Chun Ming

doi:10.1016/j.yexcr.2005.12.015

Cited by 50 publications

(42 citation statements)

References 38 publications

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“…Furthermore, two previous studies suggested that CDCA8 plays a crucial role in cancer progression, although the mechanism is largely unknown. Patients with gastric or lung cancer showing higher nuclear accumulation or expression of CDCA8 represented a shorter tumor-specific survival period (11,12). Compared with chemosensitive tumors, CDCA8 has higher expression in chemoresis- tant epithelial ovarian tumors, suggesting its role in the chemoresistance of cancer (13).…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of the CPC components Aurora B (4,5), INCENP (6), and survivin (7)(8)(9)(10) is associated with tumorigenesis in human cancers. CDCA8 is a putative oncogene that is up-regulated in many types of cancer tissues (11)(12)(13)(14) but has very low or absent expression in normal tissues (12). Its overexpression is required for growth, survival, and the malignant nature of lung cancer cells (12).…”

mentioning

confidence: 99%

“…Its overexpression is required for growth, survival, and the malignant nature of lung cancer cells (12). Overexpression and nuclear accumulation of CDCA8 are linked to the poor prognosis of lung cancer (12) and gastric cancer (11). Thus, CDCA8 was considered to be a promising target for the development of novel therapeutics and diagnostics (12).…”

mentioning

confidence: 99%

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Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer Cells

Dai

Miao

et al. 2015

Journal of Biological Chemistry

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Background:The regulation of CDCA8 gene expression remains unclear. Results: CDCA8 promoter is activated in hESCs and cancer cells, in which NF-Y is a positive-regulator by binding to the CCAAT-box. Conclusion: CDCA8 is transcriptionally activated in hESCs and cancer cells and is positively regulated by NF-Y. Significance: Characterization of CDCA8 regulation provides a better understanding of its biological functions.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer Cells

Dai

Miao

et al. 2015

Journal of Biological Chemistry

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“…Similarly, correlative data from fewer studies showing overexpression of Aurora-B Kinase in solid tumors and tumor cell lines have been reported [23][24][25][26]. On the contrary there is only one study investigating Borealin immunohistochemical expression in cancer tissues, showing a positive relationship between its nuclear accumulation and poor prognosis in cases of gastric adenocarcinoma [27]. According to our knowledge there are no reports concerning immunohistochemical detection of INCENP in human cancer tissues.…”

Section: Discussionmentioning

confidence: 93%

INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas

Barbanis

Ιωάννου

Kouvaras

et al. 2008

Pathol. Oncol. Res.

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Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge this is the first study investigating immunohistochemical expression of INCENP in lymphoma cases and cancer tissues in general. Our purpose was to characterize the expression of INCENP in cases of non-Hodgkin B-cell lymphomas, to compare the immunoreactivity between low and high grades and to evaluate the correlation between INCENP and MIB-1 labeling indices. We examined INCENP and MIB-1 immunoreactivity in paraffin sections of 55 samples of non-Hodgkin B-cell lymphomas, obtained from 55 patients, 31 men and 24 women. Thirty were of high grade and 25 were of low grade. Our results showed significantly higher nuclear immunohistochemical expression of INCENP in high grade B-cell lymphomas versus low grade ones. Also INCENP expression was significantly correlated with MIB-1 labeling index. Taken together our results point to a possible association between increased INCENP immunostaining and B-cell lymphoma aggressiveness and also stress the need for further investigating the expression of INCENP and other mitotic regulatory proteins in lymphomas and other malignant neoplasms.

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“…Additional evidence has shown that Survivin is associated with prognosis in many tumors and the potential of chromosomal passengers as mediators of tumorigenesis (Nguyen and Ravid, 2006). Aberrant Borealin/DasraB expression is linked to gastric cancer (Chang et al, 2006b). It may also be of interest to examine the effects of crossing borealin gene hypomorphs with well-known mouse tumor models to determine whether the reduced expression of Borealin/DasraB may mediate tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality

Yamanaka

Heike

Kumada

et al. 2008

Mechanisms of Development

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Borealin/DasraB is a member of the chromosomal passenger protein complex (CPC) required for proper segregation of chromosomes during mitosis. In Drosophila melanogaster, inactivation of Borealin/DasraB results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. However, the in vivo role of mammalian Borealin/DasraB remains unclear. Here, we analyzed the expression of Borealin/DasraB and found that borealin is widely expressed in embryonic tissues and later restricted to adult tissues which relies on rapid cell proliferation. To determine the role of borealin during mouse development, we generated borealin-null mice through targeted disruption. While heterozygous mice developed normally, disruption of both borealin alleles resulted in early embryonic lethality by 5.5 dpc (days postcoitus) due to mitotic defects and apoptosis in blastocyst cells that showed microtubule disorganization and no CPC enrichment. At 5.5 dpc, borealin-null embryos exhibited excessive apoptosis and elevated expression of p53. However, loss of p53 did not abrogate or delay embryonic lethality, revealing that Borealin/DasraB inactivation triggered impaired mitosis and apoptosis though p53-independent mechanisms. Our data show that Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53.

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Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer

Cited by 50 publications

References 38 publications

Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer Cells

Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer Cells

INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas

Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality

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