Bordetella

Register, Karen B.; Harvill, Eric T.

doi:10.1002/9780470958209.ch21

Cited by 3 publications

(1 citation statement)

References 82 publications

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“…Necrosis of bronchial or bronchiolar epithelium was noted in 68% of cases with evidence of B. bronchiseptica infection. Both tracheal cytotoxin and dermonecrotic toxin may contribute to lesions of the respiratory epithelium during Bordetella infections in other hosts, 23 but the possible role of these or other toxins in the lesions observed in our study is unknown. Underlying viral infections may also have caused epithelial necrosis.…”

Section: Discussionmentioning

confidence: 80%

Cilia-associated bacteria in fatal Bordetella bronchiseptica pneumonia of dogs and cats

et al. 2016

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Bordetella bronchiseptica frequently causes nonfatal tracheobronchitis, but its role in fatal pneumonia is less recognized. Our study evaluated histologic identification of cilia-associated bacteria as a method for diagnosis of B. bronchiseptica pneumonia. Cases of fatal bronchopneumonia were studied retrospectively, excluding neonates and cases of aspiration pneumonia, minor lung lesions, or autolysis. The study population comprised 36 canine and 31 feline cases of bronchopneumonia. B. bronchiseptica was identified in 8 of 36 canine and 14 of 31 feline cases based on immunohistochemistry (IHC) using serum from a rabbit hyperimmunized with pertactin, PCR testing (Fla2/Fla12), and/or bacterial culture data when available. Of these, IHC was positive in 4 canine and 7 feline cases, PCR was positive in 8 canine and 14 feline cases, and B. bronchiseptica was isolated in 2 of 5 canine and 3 of 9 feline cases tested. Examination of histologic sections stained with hematoxylin and eosin revealed bronchial cilia-associated bacteria in 4 of 36 canine and 5 of 31 feline cases; these were all positive by IHC and PCR. The presence of cilia-associated bacteria had been noted in the pathology report for only 2 of these 9 cases. Thus, the presence of cilia-associated bacteria seems frequently overlooked by pathologists, but is a diagnostically significant feature of B. bronchiseptica pneumonia. A specific diagnosis of B. bronchiseptica pneumonia is important because it suggests primary or opportunistic bacterial pneumonia rather than aspiration pneumonia, and because of the risk of animal-to-animal transmission of B. bronchiseptica, the availability of vaccines for disease prevention, and the potential zoonotic risk to immunocompromised pet owners.

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Section: Discussionmentioning

confidence: 80%

Cilia-associated bacteria in fatal Bordetella bronchiseptica pneumonia of dogs and cats

et al. 2016

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Pasteurellosis and Other Respiratory Bacterial Infections

Boulianne

Blackall

Hofacre³

et al. 2019

Diseases of Poultry

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Spatio-temporal trends in richness and persistence of bacterial communities in decline-phase water vole populations

Villette

Afonso

Couval³

et al. 2020

Sci Rep

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Understanding the driving forces that control vole population dynamics requires identifying bacterial parasites hosted by the voles and describing their dynamics at the community level. To this end, we used high-throughput DNA sequencing to identify bacterial parasites in cyclic populations of montane water voles that exhibited a population outbreak and decline in 2014-2018. An unexpectedly large number of 155 Operational Taxonomic Units (OTUs) representing at least 13 genera in 11 families was detected. Individual bacterial richness was higher during declines, and vole body condition was lower. Richness as estimated by Chao2 at the local population scale did not exhibit clear seasonal or cycle phase-related patterns, but at the vole meta-population scale, exhibited seasonal and phase-related patterns. Moreover, bacterial OTUs that were detected in the low density phase were geographically widespread and detected earlier in the outbreak; some were associated with each other. Our results demonstrate the complexity of bacterial community patterns with regard to host density variations, and indicate that investigations about how parasites interact with host populations must be conducted at several temporal and spatial scales: multiple times per year over multiple years, and at both local and long-distance dispersal scales for the host(s) under consideration. Rodents are the most diverse mammal group in the world, with an estimated 2,277 species 1 , a global distribution that includes every continent, except Antarctica, and terrestrial habitats ranging from arid deserts to swamps and rainforest 2. Generally characterized by fast life histories and large reproductive capacities, rodents are keystone species or ecosystem engineers in many of the ecosystems in which they are found 3,4 , but also frequently come into conflict with humans, causing significant loses in agricultural systems globally (see Singleton et al. 5 for an overview). They also act as reservoirs for many socially and economically burdensome zoonoses (e.g. 6,7), a pattern which is predicted to increase 8. Of particular interest to population ecologists for more than 100 years is the phenomenon of the rodent outbreak, in which the population in question exhibits dramatic multi-annual fluctuations in abundance, often with such a degree of regularity that these outbreaks are considered cycles, with four distinct phases. The increase phase is defined as a period of large increase in abundance from one spring to the next, and is followed by the peak phase, in which abundance is stable but high 9. The peak phase can range in duration from mere weeks to a year, and is followed by the decline phase, in which abundance drops over as brief a period as months but can also take up to two years. The following low phase is characterized by stable but low population abundance. The study of these systems has generated a large body of research 10 , but a consensus regarding the underlying demographic mechanisms of these outbreaks and their intrinsic or extrinsic driver...

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Bordetella

Cited by 3 publications

References 82 publications

Cilia-associated bacteria in fatal Bordetella bronchiseptica pneumonia of dogs and cats

Cilia-associated bacteria in fatal Bordetella bronchiseptica pneumonia of dogs and cats

Pasteurellosis and Other Respiratory Bacterial Infections

Spatio-temporal trends in richness and persistence of bacterial communities in decline-phase water vole populations

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